Full Text:   <1870>

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CLC number: R571

On-line Access: 2015-09-05

Received: 2015-01-24

Revision Accepted: 2015-06-07

Crosschecked: 2015-08-10

Cited: 4

Clicked: 3720

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yuan-yuan Nian

http://orcid.org/0000-0002-0989-9417

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.9 P.805-810

http://doi.org/10.1631/jzus.B1500027


Reflux characteristics of 113 GERD patients with abnormal 24-h multichannel intraluminal impedance-pH tests


Author(s):  Yuan-yuan Nian, Cheng Feng, Fu-chun Jing, Xue-qin Wang, Jun Zhang

Affiliation(s):  Division of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710003, China

Corresponding email(s):   nianyuanyuanneve@126.com, jun3z@163.com

Key Words:  Gastroesophageal reflux disease (GERD), Multichannel intraluminal impedance-pH (MII-pH), Reflux characteristics, Off medication


Yuan-yuan Nian, Cheng Feng, Fu-chun Jing, Xue-qin Wang, Jun Zhang. Reflux characteristics of 113 GERD patients with abnormal 24-h multichannel intraluminal impedance-pH tests[J]. Journal of Zhejiang University Science B, 2015, 16(9): 805-810.

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journal="Journal of Zhejiang University Science B",
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Abstract: 
Objective: To analyze reflux parameters by means of combined multichannel intraluminal impedance and pH (MII-pH) monitoring in patients with gastroesophageal reflux disease (GERD) symptoms off medication, and to find the reflux characteristics of Chinese GERD patients and the influences of gender, age, body posture, and body mass index (BMI) on gastroesophageal reflux (GER). Methods: Between Dec. 2008 and May 2014, 125 patients with typical GERD symptoms were subjected to 24-h MII-pH monitoring. Twelve patients with normal MII-pH profiles were not considered for analysis. The reflux parameters of 113 GERD patients with abnormal MII-pH results were analyzed. Results: (1) DeMeester scores were above the normal range in 46.90% (53/113) of GERD patients. Weakly acidic refluxes were prevalent in GERD patients, and the frequency of abnormal weakly acidic reflux was 75.22% (85/113). The frequencies of abnormal symptom index (SI) and symptom association probability (SAP) were 19.47% (22/113) and 14.16% (16/113), respectively. (2) The frequencies of DeMeester scores, the %time at pH<4, and the numbers of reflux episodes and of long reflux episodes >5 min were significantly higher in male patients than in female patients. (3) The %time at pH<4 was much higher during upright periods than during supine periods. During supine periods, 31.86% (36/113) of GERD patients had delayed bolus clearance time, compared with 19.47% (22/113) during upright periods. (4) The number of abnormal DeMeester scores, %time at pH<4, and the number of acid refluxes during upright periods were significantly higher in obese GERD patients than in GERD patients with a normal BMI. Overweight GERD patients also had many more acid refluxes during upright periods than GERD patients with a normal BMI. Conclusions: Weakly acidic refluxes were prevalent in Chinese GERD patients. The factors male, gender, upright position, obesity (BMI≥25), but not age, may increase the frequency and severity of GER.

24小时食管多通道腔内阻抗-pH监测阳性的113例胃食管反流病(GERD)患者的胃食管反流特点

目的:通过分析多通道腔内阻抗-pH监测(MII-pH)阳性的胃食管反流病(GERD)患者的各项反流指标,探讨我国GERD患者的胃食管反流特点,以及性别、年龄、体位和体质指数(BMI)对反流的影响。
创新点:入组患者均经MII-pH监测证实具有客观存在的胃食管反流,分析体位和BMI对反流的影响,并且发现我国GERD患者普遍存在弱酸反流。
方法:有典型反流症状的疑诊GERD患者,进行24 h MII-pH监测,对监测结果阳性的患者纳入研究对象,分析其各反流指标以及性别、年龄、体位和BMI对反流的影响。
结论:我国GERD患者普遍存在弱酸反流,男性、直立体位、肥胖(BMI≥25)可促进胃食管反流的发生,且年龄不是胃食管反流的危险因素。

关键词:胃食管反流病(GERD);多通道腔内阻抗-pH监测(MII-pH);反流特点

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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