CLC number: R511.7
On-line Access: 2011-12-30
Received: 2011-05-23
Revision Accepted: 2011-10-27
Crosschecked: 2011-12-14
Cited: 2
Clicked: 7293
Li-hui Deng, Yi-lan Zeng, Ping Feng, Ya-ling Liu, Li-chun Wang, Yun Bai, Hong Tang. Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China[J]. Journal of Zhejiang University Science B, 2012, 13(1): 49-55.
@article{title="Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China",
author="Li-hui Deng, Yi-lan Zeng, Ping Feng, Ya-ling Liu, Li-chun Wang, Yun Bai, Hong Tang",
journal="Journal of Zhejiang University Science B",
volume="13",
number="1",
pages="49-55",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100168"
}
%0 Journal Article
%T Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China
%A Li-hui Deng
%A Yi-lan Zeng
%A Ping Feng
%A Ya-ling Liu
%A Li-chun Wang
%A Yun Bai
%A Hong Tang
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 1
%P 49-55
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100168
TY - JOUR
T1 - Clinical characteristics of critical patients with pandemic influenza A (H1N1) virus infection in Chengdu, China
A1 - Li-hui Deng
A1 - Yi-lan Zeng
A1 - Ping Feng
A1 - Ya-ling Liu
A1 - Li-chun Wang
A1 - Yun Bai
A1 - Hong Tang
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 1
SP - 49
EP - 55
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100168
Abstract: Objective: The critical illness of pandemic influenza A (h1N1) virus infection may be associated with relatively poor outcomes. The objective of this study is to describe clinical features and factors associated with the deaths of critical patients. Methods: Medical records of 26 critical patients with h1N1 infection admitted from Sept. 1 to Dec. 31, 2009, were retrospectively reviewed. Diagnosis was established by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay. Results: The mean age of the patients was (40.4±18.4) years and 73.1% of them were male. Clinical manifestations included fever, cough, and sputum production. The laboratory findings included leukocytosis, lymphopenia, C-reaction protein, and lactic dehydrogenase elevation. In this series, 17 subjects survived and 9 died. The parameters between the deaths and survivors were compared, which included acute physiology and chronic health evaluation II (APACHE II) scores (23.8±10.1 vs. 14.3±6.6, P<0.05), sequential organ failure assessment (SOFA) scores (13.3±3.0 vs. 6.6±3.3, P<0.05), and multiple organ dysfunction syndrome (MODS) scores (7.4±2.5 vs. 3.3±1.7, P<0.05). The cases of deaths had higher incidences of cardiovascular failure (100% vs. 41.2%, P<0.05), renal failure (55.6% vs. 11.7%, P<0.05), encephalopathy (44.4% vs. 5.9%, P<0.05), hepatic failure (33.3% vs. 5.9%, P<0.05), and septic shock (33.3% vs. 17.6%, P<0.05). Conclusions: The critical patients with h1N1 infection have high APACHE II, SOFA, and MODS scores, which may be associated with an increased risk of death and complex clinical courses.
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