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CLC number: R395.1; R333.6

On-line Access: 2012-11-05

Received: 2011-12-22

Revision Accepted: 2012-05-30

Crosschecked: 2012-10-21

Cited: 21

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.11 P.904-912

http://doi.org/10.1631/jzus.B1100383


Comparison of the effects of acute and chronic psychological stress on metabolic features in rats


Author(s):  Fatemeh Rostamkhani, Homeira Zardooz, Saleh Zahediasl, Babak Farrokhi

Affiliation(s):  Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; more

Corresponding email(s):   homeira_zardooz@sbmu.ac.ir

Key Words:  Psychological stress, Corticosterone, Insulin, Glucose, Cholesterol, Triglyceride


Fatemeh Rostamkhani, Homeira Zardooz, Saleh Zahediasl, Babak Farrokhi. Comparison of the effects of acute and chronic psychological stress on metabolic features in rats[J]. Journal of Zhejiang University Science B, 2012, 13(11): 904-912.

@article{title="Comparison of the effects of acute and chronic psychological stress on metabolic features in rats",
author="Fatemeh Rostamkhani, Homeira Zardooz, Saleh Zahediasl, Babak Farrokhi",
journal="Journal of Zhejiang University Science B",
volume="13",
number="11",
pages="904-912",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1100383"
}

%0 Journal Article
%T Comparison of the effects of acute and chronic psychological stress on metabolic features in rats
%A Fatemeh Rostamkhani
%A Homeira Zardooz
%A Saleh Zahediasl
%A Babak Farrokhi
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 11
%P 904-912
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100383

TY - JOUR
T1 - Comparison of the effects of acute and chronic psychological stress on metabolic features in rats
A1 - Fatemeh Rostamkhani
A1 - Homeira Zardooz
A1 - Saleh Zahediasl
A1 - Babak Farrokhi
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 11
SP - 904
EP - 912
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100383


Abstract: 
This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communication box acutely (1 d) and chronically (15 and 30 d). Blood sampling was carried out by retro-orbital-puncture method. The plasma levels of glucose, cholesterol, triglyceride, insulin, and corticosterone were measured. In addition, feed and water intake, latency to eat and drink, adrenal and body weights were determined. Acute and chronic psychological stress did not significantly change basal plasma corticosterone levels. However, immediately (1 min) after acute exposure to stress, plasma corticosterone level increased compared to that before stress exposure. Acute stress increased plasma insulin levels significantly. Fifteen days of stress exposure resulted in plasma glucose increase. Chronic stress significantly increased feed intake, latency to eat, and adrenal weight compared to acute stress. The body weights of both control and stressed groups increased markedly during the experiment. Homeostasis model assessment of insulin resistance (HOMA-IR) index did not change significantly in the stressed group. In conclusion, application of acute and chronic psychological stress leads to different metabolic and/or behavioral changes but the metabolic changes resulting from acute exposure to stress seem to be more pronounced.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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