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CLC number: R965; R285.5

On-line Access: 2012-02-29

Received: 2011-04-21

Revision Accepted: 2011-08-30

Crosschecked: 2012-02-17

Cited: 19

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.3 P.176-185


Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

Author(s):  Zariyantey Abdul Hamid, Siti Balkis Budin, Ng Wen Jie, Asmah Hamid, Khairana Husain, Jamaludin Mohamed

Affiliation(s):  Department of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; more

Corresponding email(s):   balkis6466@yahoo.com.my

Key Words:  Zingiber zerumbet, Antioxidant, Oxidative stress, Nephrotoxicity, Paracetamol

Zariyantey Abdul Hamid, Siti Balkis Budin, Ng Wen Jie, Asmah Hamid, Khairana Husain, Jamaludin Mohamed. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats[J]. Journal of Zhejiang University Science B, 2012, 13(3): 176-185.

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author="Zariyantey Abdul Hamid, Siti Balkis Budin, Ng Wen Jie, Asmah Hamid, Khairana Husain, Jamaludin Mohamed",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats
%A Zariyantey Abdul Hamid
%A Siti Balkis Budin
%A Ng Wen Jie
%A Asmah Hamid
%A Khairana Husain
%A Jamaludin Mohamed
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 3
%P 176-185
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100133

T1 - Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats
A1 - Zariyantey Abdul Hamid
A1 - Siti Balkis Budin
A1 - Ng Wen Jie
A1 - Asmah Hamid
A1 - Khairana Husain
A1 - Jamaludin Mohamed
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 3
SP - 176
EP - 185
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100133

paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg), 750 mg/kg PCM+200 mg/kg extract (PCM+200-extract), and 750 mg/kg PCM+400 mg/kg extract (PCM+400-extract), respectively, for seven consecutive days. The Z. zerumbet extract was given intraperitoneally concurrent with oral administration of PCM. Treatment with Z. zerumbet extract at doses of 200 and 400 mg/kg prevented the PCM-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of plasma creatinine, plasma and renal malondialdehyde (MDA), plasma protein carbonyl, and renal advanced oxidation protein product (AOPP). Furthermore, both doses were also able to induce a significant increment (P<0.05) of plasma and renal levels of glutathione (GSH) and plasma superoxide dismutase (SOD) activity. The nephroprotective effects of Z. zerumbet extract were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, Z. zerumbet extract administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, ethyl acetate extract of Z. zerumbet rhizome has a protective role against PCM-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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