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CLC number: R542.2+2

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2011-06-29

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.638-643

http://doi.org/10.1631/jzus.B1101007


Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow


Author(s):  Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li

Affiliation(s):  Department of Cardiology, China-Japan Friendship Hospital, Beijing 100029, China

Corresponding email(s):   lixianlun@hotmail.com

Key Words:  Liposomal prostaglandin E1 (lipo-PGE1), Reperfusion no-reflow, Myocardial infarction


Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li. Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow[J]. Journal of Zhejiang University Science B, 2011, 12(8): 638-643.

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author="Jia-hui Li, Peng Yang, Ai-li Li, Yong Wang, Yuan-nan Ke, Xian-lun Li",
journal="Journal of Zhejiang University Science B",
volume="12",
number="8",
pages="638-643",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1101007"
}

%0 Journal Article
%T Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow
%A Jia-hui Li
%A Peng Yang
%A Ai-li Li
%A Yong Wang
%A Yuan-nan Ke
%A Xian-lun Li
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 8
%P 638-643
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1101007

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T1 - Cardioprotective effect of liposomal prostaglandin E1 on a porcine model of myocardial infarction reperfusion no-reflow
A1 - Jia-hui Li
A1 - Peng Yang
A1 - Ai-li Li
A1 - Yong Wang
A1 - Yuan-nan Ke
A1 - Xian-lun Li
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 638
EP - 643
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1101007


Abstract: 
Objective: To evaluate whether liposomal prostaglandin E1 (lipo-PGE1) can decrease reperfusion no-reflow in a catheter-based porcine model of acute myocardial infarction (AMI). Methods: Twenty-two male Chinese mini-swines were randomized into three groups: six in a sham-operation group, and eight each in the control and lipo-PGE1 groups. The distal part of the left anterior descending coronary artery (LAD) in the latter two groups was completely occluded for 2 h, and then reperfused for 3 h. Lipo-PGE1 (1 μg/kg) was injected 10 min before LAD occlusion until reperfusion for 1 h in the lipo-PGE1 group. Hemodynamic data and proinflammatory cytokines were examined before AMI, 2 h after occlusion, and 1, 2, and 3 h after reperfusion. Myocardial contrast echocardiography (MCE) and double staining were performed to evaluate the myocardial no-reflow area (NRA). Results: Left ventricular systolic pressure and end-diastolic pressure significantly improved in the lipo-PGE1 group after reperfusion compared with the control group and also 2 h after AMI (P<0.05 for both). MCE and double staining both showed that lipo-PGE1 decreased reperfusion NRA after AMI (P<0.05, P<0.01). Lipo-PGE1 decreased serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) after myocardial infarction reperfusion (P<0.05 for both). Conclusions: Lipo-PGE1 is cardioprotective in our porcine model of myocardial infarction reperfusion no-reflow, decreasing NRA and attenuating the inflammatory response.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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