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CLC number: R656.6+1

On-line Access: 2013-06-04

Received: 2012-07-19

Revision Accepted: 2013-04-01

Crosschecked: 2013-05-17

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.6 P.468-478


Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer

Author(s):  Long-yun Ye, Da-ren Liu, Chao Li, Xiao-wen Li, Ling-na Huang, Sheng Ye, Yi-xiong Zheng, Li Chen

Affiliation(s):  Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   yelongyun@126.com, chenli_hz@yahoo.com

Key Words:  Gastric cancer, Laparoscopic gastrectomy, Meta-analysis, Mortality, Recurrence

Long-yun Ye, Da-ren Liu, Chao Li, Xiao-wen Li, Ling-na Huang, Sheng Ye, Yi-xiong Zheng, Li Chen. Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer[J]. Journal of Zhejiang University Science B, 2013, 14(6): 468-478.

@article{title="Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer",
author="Long-yun Ye, Da-ren Liu, Chao Li, Xiao-wen Li, Ling-na Huang, Sheng Ye, Yi-xiong Zheng, Li Chen",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer
%A Long-yun Ye
%A Da-ren Liu
%A Chao Li
%A Xiao-wen Li
%A Ling-na Huang
%A Sheng Ye
%A Yi-xiong Zheng
%A Li Chen
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 6
%P 468-478
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200197

T1 - Systematic review of laparoscopy-assisted versus open gastrectomy for advanced gastric cancer
A1 - Long-yun Ye
A1 - Da-ren Liu
A1 - Chao Li
A1 - Xiao-wen Li
A1 - Ling-na Huang
A1 - Sheng Ye
A1 - Yi-xiong Zheng
A1 - Li Chen
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 6
SP - 468
EP - 478
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200197

Objective: The study compared laparoscopy-assisted gastrectomy (LAG) with open gastrectomy (OG) in the management of advanced gastric cancer (AGC). Methods: Literature search was performed in the Medline, Embase, and Cochrane Library databases to identify control studies that compared LAG and OG for AGC. A meta-analysis was conducted to examine the surgical safety and oncologic adequacy, using the random-effect model. Results: Seven eligible studies including 815 patients were analyzed. LAG was associated with less blood loss, less use of analgesics, shorter time of flatus and periods of hospital stay, but longer time of operation. The incidence of most complications was similar between the two groups. However, LAG was associated with a lower rate of pulmonary infection (odds ratio (OR) 0.19; 95% confidence interval (CI) 0.05 to 0.68; P<0.05). No significant differences were noted in terms of the number of harvested lymph nodes (weighted mean difference (WMD) 1.165; 95% CI −2.000 to 4.311; P>0.05), overall mortality (OR 0.65; 95% CI 0.39 to 1.10; P>0.05), cancer-related mortality (OR 0.64; 95% CI 0.32 to 1.25; P>0.05), or recurrence (OR 0.62; 95% CI 0.33 to 1.16; P>0.05). Conclusions: LAG could be performed safely for AGC with adequate lymphadenectomy and has several short-term advantages compared with conventional OG. No differences were found in long-term outcomes. However, these results should be validated in large randomized controlled studies (RCTs) with sufficient follow-up.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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