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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.1 P.9-22


A systematic review of herbal medicines for the treatment of cancer cachexia in animal models

Author(s):  Bongki Park, Sooseong You, William C. S. Cho, Jun-Yong Choi, Myeong Soo Lee

Affiliation(s):  Liver and Immunology Research Center, Oriental College, Daejeon University, Daejeon 34020, Republic of Korea; more

Corresponding email(s):   drmslee@gmail.com, mslee@kiom.re.kr

Key Words:  Cancer, Cachexia, Herbal medicine, Traditional East Asian medicine systematic review

Bongki Park, Sooseong You, William C. S. Cho, Jun-Yong Choi, Myeong Soo Lee. A systematic review of herbal medicines for the treatment of cancer cachexia in animal models[J]. Journal of Zhejiang University Science B, 2019, 20(1): 9-22.

@article{title="A systematic review of herbal medicines for the treatment of cancer cachexia in animal models",
author="Bongki Park, Sooseong You, William C. S. Cho, Jun-Yong Choi, Myeong Soo Lee",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T A systematic review of herbal medicines for the treatment of cancer cachexia in animal models
%A Bongki Park
%A Sooseong You
%A William C. S. Cho
%A Jun-Yong Choi
%A Myeong Soo Lee
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 1
%P 9-22
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800171

T1 - A systematic review of herbal medicines for the treatment of cancer cachexia in animal models
A1 - Bongki Park
A1 - Sooseong You
A1 - William C. S. Cho
A1 - Jun-Yong Choi
A1 - Myeong Soo Lee
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 1
SP - 9
EP - 22
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800171

Objective: The aim of this study is to summarize preclinical studies on herbal medicines used to treat cancer cachexia and its underlying mechanisms. Methods: We searched four representing databases, including PubMed, EMBASE, the Allied and Complementary Medicine Database, and the Web of Science up to December 2016. Randomized animal studies were included if the effects of any herbal medicine were tested on cancer cachexia. The methodological quality was evaluated by the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADE) checklist. Results: A total of fourteen herbal medicines and their compounds were identified, including Coptidis Rhizoma, berberine, Bing De Ling, curcumin, Qing-Shu-Yi-Qi-Tang, Scutellaria baicalensis, Hochuekkito, Rikkunshito, hesperidin, atractylodin, Sipjeondaebo-tang, Sosiho-tang, Anemarrhena Rhizoma, and Phellodendri Cortex. All the herbal medicines, except curcumin, have been shown to ameliorate the symptoms of cancer cachexia through anti-inflammation, regulation of the neuroendocrine pathway, and modulation of the ubiquitin proteasome system or protein synthesis. Conclusions: This study showed that herbal medicines might be a useful approach for treating cancer cachexia. However, more detailed experimental studies on the molecular mechanisms and active compounds are needed.


概要:本综述总结利用中草药治疗癌症恶病质的临床前研究及其潜在的机制,是首个针对中草药治疗癌症恶病质动物模型成效进行系统性回顾评价的研究.本文通过检索PubMed、EMBASE、Allied and Complementary Medicine Database以及Web of Science四大代表性的资料库(检索时间至2016年12月),就中草药治疗癌症恶病质的随机对照动物试验进行系统性回顾分析,并采用CAMARADE评分清单进行质量评价.分析结果显示:在十四项中草药及其化合物中,除了姜黄素外其他如黄连、黄连素、病得灵、清暑益气汤、黄芩、补中益气汤、六君子汤、橙皮苷、苍术呋喃烃、十全大补汤、小柴胡汤、知母及黄柏等都已被证实可以通过抗炎、调节神经内分泌途径、调节泛素蛋白酶体系统或蛋白质合成来改善癌症恶病质的症状.因此,利用中草药治疗癌症恶病质是一种有效的方法.然而该结论尚需要有更详细的分子机制和活性化合物的实验研究验证.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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