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CLC number: R4; Q78

On-line Access: 2012-08-01

Received: 2012-06-20

Revision Accepted: 2012-07-13

Crosschecked: 2012-07-19

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.8 P.603-608

http://doi.org/10.1631/jzus.B1201006


Global impact of RNA splicing on transcriptome remodeling in the heart


Author(s):  Chen Gao, Yibin Wang

Affiliation(s):  Molecular Biology Institute, University of California, Los Angeles, California 90095, USA

Corresponding email(s):   yibinwang@mednet.ucla.edu

Key Words:  Alternative RNA splicing, Transcriptome, Gene regulation, Heart, RNA-seq


Chen Gao, Yibin Wang. Global impact of RNA splicing on transcriptome remodeling in the heart[J]. Journal of Zhejiang University Science B, 2012, 13(8): 603-608.

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author="Chen Gao, Yibin Wang",
journal="Journal of Zhejiang University Science B",
volume="13",
number="8",
pages="603-608",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1201006"
}

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%T Global impact of RNA splicing on transcriptome remodeling in the heart
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%A Yibin Wang
%J Journal of Zhejiang University SCIENCE B
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%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1201006

TY - JOUR
T1 - Global impact of RNA splicing on transcriptome remodeling in the heart
A1 - Chen Gao
A1 - Yibin Wang
J0 - Journal of Zhejiang University Science B
VL - 13
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SP - 603
EP - 608
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1201006


Abstract: 
In the eukaryotic transcriptome, both the numbers of genes and different RNA species produced by each gene contribute to the overall complexity. These RNA species are generated by the utilization of different transcriptional initiation or termination sites, or more commonly, from different messenger RNA (mRNA) splicing events. Among the 30000+ genes in human genome, it is estimated that more than 95% of them can generate more than one gene product via alternative RNA splicing. The protein products generated from different RNA splicing variants can have different intracellular localization, activity, or tissue-distribution. Therefore, alternative RNA splicing is an important molecular process that contributes to the overall complexity of the genome and the functional specificity and diversity among different cell types. In this review, we will discuss current efforts to unravel the full complexity of the cardiac transcriptome using a deep-sequencing approach, and highlight the potential of this technology to uncover the global impact of RNA splicing on the transcriptome during development and diseases of the heart.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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