Full Text:   <946>

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CLC number: R34

On-line Access: 2020-10-12

Received: 2020-05-10

Revision Accepted: 2020-08-10

Crosschecked: 2020-09-07

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Citations:  Bibtex RefMan EndNote GB/T7714


Zheng-gang Yang


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.10 P.767-778


Emerging relationship between RNA helicases and autophagy

Author(s):  Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang

Affiliation(s):  The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   yangzg@zju.edu.cn

Key Words:  RNA helicase, Autophagy, Homeostasis, Regulation

Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang. Emerging relationship between RNA helicases and autophagy[J]. Journal of Zhejiang University Science B, 2020, 21(10): 767-778.

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author="Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Emerging relationship between RNA helicases and autophagy
%A Miao-miao Zhao
%A Ru-sha Wang
%A Yan-lin Zhou
%A Zheng-gang Yang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 10
%P 767-778
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000245

T1 - Emerging relationship between RNA helicases and autophagy
A1 - Miao-miao Zhao
A1 - Ru-sha Wang
A1 - Yan-lin Zhou
A1 - Zheng-gang Yang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 10
SP - 767
EP - 778
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000245

RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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