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CLC number: R34

On-line Access: 2020-10-12

Received: 2020-05-10

Revision Accepted: 2020-08-10

Crosschecked: 2020-09-07

Cited: 0

Clicked: 1435

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Zheng-gang Yang

https://orcid.org/0000-0001-9014-2245

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.10 P.767-778

http://doi.org/10.1631/jzus.B2000245


Emerging relationship between RNA helicases and autophagy


Author(s):  Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang

Affiliation(s):  The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   yangzg@zju.edu.cn

Key Words:  RNA helicase, Autophagy, Homeostasis, Regulation


Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang. Emerging relationship between RNA helicases and autophagy[J]. Journal of Zhejiang University Science B, 2020, 21(10): 767-778.

@article{title="Emerging relationship between RNA helicases and autophagy",
author="Miao-miao Zhao, Ru-sha Wang, Yan-lin Zhou, Zheng-gang Yang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="10",
pages="767-778",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000245"
}

%0 Journal Article
%T Emerging relationship between RNA helicases and autophagy
%A Miao-miao Zhao
%A Ru-sha Wang
%A Yan-lin Zhou
%A Zheng-gang Yang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 10
%P 767-778
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000245

TY - JOUR
T1 - Emerging relationship between RNA helicases and autophagy
A1 - Miao-miao Zhao
A1 - Ru-sha Wang
A1 - Yan-lin Zhou
A1 - Zheng-gang Yang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 10
SP - 767
EP - 778
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000245


Abstract: 
RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.

RNA解旋酶和自噬之间的新关系

概要:RNA解旋酶是参与RNA代谢的最大的蛋白质家族,通过翻译和前体RNA剪接等各种过程来稳定细胞内环境.这些蛋白质还与一些疾病有关,如癌症和病毒性疾病.自噬是一种自我消化和保护细胞的运输过程,通过降解多余的细胞器和细胞垃圾来稳定内部环境或维持细胞的基本生存,与人类疾病有关.与自噬相似,RNA解旋酶在维持细胞内稳态中发挥着重要的作用,与多种疾病相关.近年来的研究表明,RNA解旋酶与自噬密切相关,参与调节自噬或作为自噬与其他细胞活动之间的桥梁,广泛影响了一些病理生理过程.本文总结了最新的研究,以了解RNA解旋酶调节自噬的机制以及这些机制与疾病之间的联系.
关键词:RNA解旋酶;自噬;内稳态;调节

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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