Full Text:   <2877>

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CLC number: X513

On-line Access: 2014-01-04

Received: 2013-03-01

Revision Accepted: 2013-07-12

Crosschecked: 2013-12-25

Cited: 2

Clicked: 6243

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.1 P.75-83


Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs*

Author(s):  Duriya Fongmoon1, Surathat Pongnikorn1, Aphiruk Chaisena2, Sitthichai Iamsaard3

Affiliation(s):  1. Department of Medical Services, Lampang Cancer Hospital, Ministry of Public Health, Lampang 52000, Thailand; more

Corresponding email(s):   iamsaard_sitt@yahoo.com

Key Words:  Particulate matter (PM), Ceramic factory, Lampang Province, Rat lung

Duriya Fongmoon, Surathat Pongnikorn, Aphiruk Chaisena, Sitthichai Iamsaard. Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs[J]. Journal of Zhejiang University Science B, 2014, 15(1): 75-83.

@article{title="Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs",
author="Duriya Fongmoon, Surathat Pongnikorn, Aphiruk Chaisena, Sitthichai Iamsaard",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs
%A Duriya Fongmoon
%A Surathat Pongnikorn
%A Aphiruk Chaisena
%A Sitthichai Iamsaard
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 1
%P 75-83
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300058

T1 - Particulate matters collected from ceramic factories in Lampang Province affecting rat lungs
A1 - Duriya Fongmoon
A1 - Surathat Pongnikorn
A1 - Aphiruk Chaisena
A1 - Sitthichai Iamsaard
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 1
SP - 75
EP - 83
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300058

Background: Lung cancer ranks as the fifth largest of all cancer cases in Thailand. However, it is the first leading cancer in the northern part of Thailand (data from 2003–2007). There are several predisposing causes that lead to lung cancer and one important inducement is particulate matters (PMs). lampang Province in Thailand is famous for the ceramic industry, where there are over 200 ceramic industrial factories. PMs are produced during the ceramic manufacturing process and spread throughout all of the working areas. It is very possible that workers could directly inhale PM-contaminated air during working hours. Objective: This study focuses on the toxic effects of PMs collected from ceramic factories on genes and lungs of rats. Methods: PMs collected from six ceramic factories in lampang Province were extracted using dimethyl sulfoxide (DMSO). The inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) were used to analyze the chemical elements at lower and higher concentrations, respectively. Then, the toxicity of PMs on the genes was examined by the Ames test, and subsequently, the effect of PMs on DNA was examined by quantifying the amount of 8-hydroxy-2′-deoxyguanosine (8-OHdG). Finally, the toxicity of the PMs on rat’s lungs was examined by histology. Results: As chemical elements of lower concentrations, cadmium, chromium, nickel, copper, and lead were detected by ICP-MS. As chemical elements of higher concentrations, manganese, magnesium, zinc, iron, potassium, calcium, and sodium were detected by ICP-OES. No mutagenicity in Salmonella typhimurium was found in the PM extracts from all six factories by utilizing the Ames test. In the histological study, the reduction in spaces of alveolar ducts and sacs, and terminal bronchioles, the thickening of interstitial connective tissues were noted by PM extracts in high amounts (100 and 350 μg). Female rats were more sensitive to PM extracts than males in terms of their pulmonary damages. Conclusions: PMs were not mutagenic to S. typhimurium but can damage the lung tissue of rats.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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