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CLC number: R58

On-line Access: 2014-06-07

Received: 2013-04-16

Revision Accepted: 2013-08-15

Crosschecked: 2014-05-16

Cited: 4

Clicked: 6308

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.6 P.566-574


Proteins induced by telomere dysfunction are associated with human IgA nephropathy* #

Author(s):  Ying-ying Lu1, Xian Yang1, Wen-qing Chen1, Zhen-yu Ju2, Zhang-fei Shou1, Juan Jin1, Xiao-hui Zhang1, Jiang-hua Chen1, Hong Jiang1

Affiliation(s):  1. Kidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   annie_jh2000@aliyun.com

Key Words:  Biomarkers, Telomere, IgA nephropathy (IgAN)

Ying-ying Lu, Xian Yang, Wen-qing Chen, Zhen-yu Ju, Zhang-fei Shou, Juan Jin, Xiao-hui Zhang, Jiang-hua Chen, Hong Jiang. Proteins induced by telomere dysfunction are associated with human IgA nephropathy[J]. Journal of Zhejiang University Science B, 2014, 15(6): 566-574.

@article{title="Proteins induced by telomere dysfunction are associated with human IgA nephropathy",
author="Ying-ying Lu, Xian Yang, Wen-qing Chen, Zhen-yu Ju, Zhang-fei Shou, Juan Jin, Xiao-hui Zhang, Jiang-hua Chen, Hong Jiang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Proteins induced by telomere dysfunction are associated with human IgA nephropathy
%A Ying-ying Lu
%A Xian Yang
%A Wen-qing Chen
%A Zhen-yu Ju
%A Zhang-fei Shou
%A Juan Jin
%A Xiao-hui Zhang
%A Jiang-hua Chen
%A Hong Jiang
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 6
%P 566-574
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300115

T1 - Proteins induced by telomere dysfunction are associated with human IgA nephropathy
A1 - Ying-ying Lu
A1 - Xian Yang
A1 - Wen-qing Chen
A1 - Zhen-yu Ju
A1 - Zhang-fei Shou
A1 - Juan Jin
A1 - Xiao-hui Zhang
A1 - Jiang-hua Chen
A1 - Hong Jiang
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 6
SP - 566
EP - 574
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300115

Aging is one of the contributing risk factors for kidney diseases. Accumulating evidence prompts the view that telomere length in kidney tissue cells is an indicator for organismal aging. Previously identified aging markers (cathelin-related antimicrobial peptide (CRAMP), stathmin, elongation factor-1α (EF-1α), and chitinase) were associated not only with telomere driven aging in mice but also with human aging and chronic diseases. This study focuses on the relationship between these biomarkers and igA nephropathy (IgAN) progression in the Chinese population. For 260 individuals, the four markers are determined in blind datasets using direct enzyme-linked immunosorbent assay (ELISA) and immunofluorescence staining. The expression levels of CRAMP and chitinase increased in blood plasma, urine, and kidney tissues during human IgAN progression. And for the other nephropathy, such as systemic lupus erythematosus (SLE), diabetic nephropathy (DN), and focal segmental glomerulosclerosis (FSGS), there is no protein upregulation with telomere shortening. Moreover, a combination of CRAMP and chitinase can distinguish patients with IgAN from healthy individuals with 88.2%/92.5% (plasma) and 74.3%/84.2% (urine) sensitivity/specificity. These data provide the experimental evidence that telomere shortening and related inflammatory proteins are associated with human IgAN, and it could be a new direction for the disease progression study.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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