Full Text:   <1840>

Summary:  <1743>

CLC number: R711.76

On-line Access: 2014-08-05

Received: 2014-03-18

Revision Accepted: 2014-07-07

Crosschecked: 2014-07-18

Cited: 1

Clicked: 5104

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.8 P.750-755

http://doi.org/10.1631/jzus.B1400081


Heterochronic bilateral ectopic pregnancy after ovulation induction*


Author(s):  Bo Zhu1, Gu-feng Xu1,2, Yi-feng Liu1,2, Fan Qu1,2, Wei-miao Yao1, Yi-min Zhu1,2, Hui-juan Gao1,2, Dan Zhang1,2

Affiliation(s):  1. Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   zhangdan61@hotmail.com

Key Words:  Heterochronic bilateral ectopic pregnancy, Assisted reproductive technology, Intrauterine insemination, Ovulation induction


Bo Zhu, Gu-feng Xu, Yi-feng Liu, Fan Qu, Wei-miao Yao, Yi-min Zhu, Hui-juan Gao, Dan Zhang. Heterochronic bilateral ectopic pregnancy after ovulation induction[J]. Journal of Zhejiang University Science B, 2014, 15(8): 750-755.

@article{title="Heterochronic bilateral ectopic pregnancy after ovulation induction",
author="Bo Zhu, Gu-feng Xu, Yi-feng Liu, Fan Qu, Wei-miao Yao, Yi-min Zhu, Hui-juan Gao, Dan Zhang",
journal="Journal of Zhejiang University Science B",
volume="15",
number="8",
pages="750-755",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400081"
}

%0 Journal Article
%T Heterochronic bilateral ectopic pregnancy after ovulation induction
%A Bo Zhu
%A Gu-feng Xu
%A Yi-feng Liu
%A Fan Qu
%A Wei-miao Yao
%A Yi-min Zhu
%A Hui-juan Gao
%A Dan Zhang
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 8
%P 750-755
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400081

TY - JOUR
T1 - Heterochronic bilateral ectopic pregnancy after ovulation induction
A1 - Bo Zhu
A1 - Gu-feng Xu
A1 - Yi-feng Liu
A1 - Fan Qu
A1 - Wei-miao Yao
A1 - Yi-min Zhu
A1 - Hui-juan Gao
A1 - Dan Zhang
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 8
SP - 750
EP - 755
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400081


Abstract: 
Ectopic pregnancy is identified with the widely-applied assisted reproductive technology (ART). Bilateral ectopic pregnancy is a rare form of ectopic pregnancy which is difficult to be diagnosed at the pre-operation stage. In this paper, we presented an unusual case of heterochronic bilateral ectopic pregnancy after stimulated intrauterine insemination (IUI), where there has been a delay of 22 d between the diagnoses of the two ectopic pregnancies. Literature was reviewed on the occurrence of bilateral ectopic pregnancy during the past four years in the MEDLINE database. We found 16 cases of bilateral ectopic pregnancy reported since 2008, and analyzed the characteristics of those cases of bilateral ectopic pregnancy. We emphasize that ovulation induction and other ARTs may increase the risk of bilateral ectopic pregnancy. Because of the difficulty in identification of bilateral ectopic pregnancy by ultrasonography, the clinician should be aware that the treatment of one ectopic pregnancy does not preclude the occurrence of a second ectopic pregnancy in the same patient and should pay attention to the intra-operation inspection of both side fallopian tubes in any ectopic pregnancy case.

促排卵后的不同步双侧异位妊娠

研究目的:报道一例不同步双侧异位妊娠,并回顾相关文献,总结规律。
创新要点:第一次报道了不同步的双侧异位妊娠。
研究方法:对促排卵后行宫腔内人工授精病人发生非同步双侧输卵管妊娠的病例进行报告,辅以人绒毛膜促性腺激素(hCG)值波动曲线、超声图像以及病理切片加以阐述;同时回顾2008年以来关于双侧异位妊娠的文献,并分析病例特征。
重要结论:促排卵后可能会提高双侧异位妊娠风险,一侧异位妊娠发生后,需要注意对侧是否也存在异位妊娠。
非同步;双侧异位妊娠;宫腔内人工授精;促排卵;辅助生殖技术

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

References

[1] Abrams, R.A., Kanter, A.E., 1948. Bilateral simultaneous extrauterine pregnancy. Am J Obstet Gynecol, 56(6):1198-1200. 


[2] Altinkaya, S.O., Ozat, M., Pektas, M.K., 2008. Simultaneous bilateral tubal pregnancy after in vitro fertilization and embryo transfer. Taiwan J Obstet Gynecol, 47(3):338-340. 


[3] Andrews, J., Farrell, S., 2008. Spontaneous bilateral tubal pregnancies: a case report. J Obstet Gynaecol Can, 30(1):51-54. 


[4] Ayoubi, J.M., Fanchin, R., 2003. Ectopic pregnancy: which side to operate?. Lancet, 362(9391):1183


[5] Bouyer, J., Coste, J., Fernandez, H., 2002. Sites of ectopic pregnancy: a 10 year population-based study of 1800 cases. Hum Reprod, 17(12):3224-3230. 


[6] Bustos Lopez, H.H., Rojas-Poceros, G., Barron Vallejo, J., 1998. Conservative laparoscopic treatment of bilateral ectopic pregnancy: 2 case reports and review of the literature. Ginecol Obstet Mex, 66:13-17. 


[7] Chang, H.J., Suh, C.S., 2010. Ectopic pregnancy after assisted reproductive technology: what are the risk factors?. Curr Opin Obstet Gynecol, 22(3):202-207. 


[8] Clayton, H.B., Schieve, L.A., Peterson, H.B., 2006. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol, 107(3):595-604. 


[9] Cohen, J., Mayaux, M.J., Guihard-Moscato, M.L., 1986.  In-vitro fertilization and embryo transfer: a collaborative study of 1163 pregnancies on the incidence and risk factors of ectopic pregnancies. Hum Reprod, 1(4):255-258. 


[10] de los Ros, J.F., Castañeda, J.D., Miryam, A., 2007. Bilateral ectopic pregnancy. J Minim Invasive Gynecol, 14(4):419-427. 


[11] El Hakim, E., Cahill, D., 2009. Concurrent bilateral ectopic pregnancy after recurrent miscarriages in a fertile woman. J Obstet Gynaecol, 29(4):359


[12] Farquhar, C.M., 2005. Ectopic pregnancy. Lancet, 366(9485):583-591. 


[13] Fernandez, H., Coste, J., Job-Spira, N., 1991. Controlled ovarian hyperstimulation as a risk factor for ectopic pregnancy. Obstet Gynecol, 78(4):656-659. 


[14] Ghaffari, F., Eftekhari Yazdi, P., Kiani, K., 2011. A case report of bilateral tubal ectopic pregnancy following day 5 embryo transfer. Arch Med Sci, 7(6):1087-1088. 


[15] Greenberg, J.A., 2008. Bilateral ectopic pregnancy. Rev Obstet Gynecol, 1(2):48


[16] Issat, T., Grzybowski, W., Jakimiuk, A.J., 2009. Bilateral ectopic tubal pregnancy, following in vitro fertilisation (IVF). Folia Histochem Cytobiol, 47(5):S147-S148. 


[17] Jeong, H.C., Park, I.H., Yoon, Y.S., 2009. Heterotopic triplet pregnancy with bilateral tubal and intrauterine pregnancy after spontaneous conception. Eur J Obstet Gynecol Reprod Biol, 142(2):161-162. 


[18] Karande, V.C., Flood, J.T., Heard, N., 1991. Analysis of ectopic pregnancies resulting from in-vitro fertilization and embryo transfer. Hum Reprod, 6(3):446-449. 


[19] Liao, C.Y., Ding, D.C., 2009. Laparoscopic management of spontaneous bilateral tubal pregnancies. J Minim Invasive Gynecol, 16(3):247


[20] Marasinghe, J.P., Condous, G., Amarasinghe, W.I., 2009. Spontaneous bilateral tubal ectopic pregnancy. Ceylon Med J, 54(1):21-22. 


[21] Marchbanks, P.A., Coulam, C.B., Annegers, J.F., 1985. An association between clomiphene citrate and ectopic pregnancy: a preliminary report. Fertil Steril, 44(2):268-270. 


[22] Martinez, J., Cabistany, A.C., Gonzalez, M., 2009. Bilateral simultaneous ectopic pregnancy. South Med J, 102(10):1055-1057. 


[23] Nazari, A., Askari, H.A., Check, J.H., 1993. Embryo transfer technique as a cause of ectopic pregnancy in in vitro fertilization. Fertil Steril, 60(5):919-921. 


[24] Pan, J., Qian, Y., Wang, J., 2010. Bilateral interstitial pregnancy after in vitro fertilization and embryo transfer with bilateral fallopian tube resection detected by transvaginal sonography. J Ultrasound Med, 29(12):1829-1832. 


[25] Plotti, F., di Giovanni, A., Oliva, C., 2008. Bilateral ovarian pregnancy after intrauterine insemination and controlled ovarian stimulation. Fertil Steril, 90(5):2015.e3-2015.e5. 


[26] Sentilhes, L., Bouet, P.E., Jalle, T., 2009. Ultrasound diagnosis of spontaneous bilateral tubal pregnancy. Aust N Z J Obstet Gynaecol, 49(6):695-696. 


[27] Shetty, J.P., Shetty, B., Makkanavar, J.H., 2011. A rare case of bilateral tubal pregnancy. J Indian Med Assoc, 109(7):506-507. 


[28] Slowey, M.J., Scoccia, B., 1993. Simultaneous bilateral ectopic pregnancy resulting from gamete intrafallopian transfer (gift). J Assist Reprod Genet, 10(4):304-308. 


[29] Stewart, H.L., 1950. Bilateral ectopic pregnancy. West J Surg Obstet Gynecol, 58(11):648-656. 


[30] Verhulst, G., Camus, M., Bollen, N., 1993. Analysis of the risk factors with regard to the occurrence of ectopic pregnancy after medically assisted procreation. Hum Reprod, 8(8):1284-1287. 


[31] Wali, A.S., Khan, R.S., 2012. Spontaneous bilateral tubal pregnancy. J Coll Physicians Surg Pak, 22(2):118-119. 


[32] Wang, L.Y., Wang, N., Le, F., 2013. Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 14(5):372-381. 


[33] Xing, L.F., Qian, Y.L., Chen, L.T., 2014. Is there a difference in cognitive development between preschool singletons and twins born after intracytoplasmic sperm injection or in vitro fertilization?. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 15(1):51-57. 


[34] Yu, H.T., Huang, H.Y., Lai, C.H., 2008. Conservative laparoscopy following prophylactic methotrexate for an unruptured bilateral tubal pregnancy. Taiwan J Obstet Gynecol, 47(4):451-453. 



Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE