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CLC number: R181.2+2

On-line Access: 2015-01-05

Received: 2014-04-18

Revision Accepted: 2014-10-28

Crosschecked: 2014-12-24

Cited: 3

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Citations:  Bibtex RefMan EndNote GB/T7714


Jian-nong WU


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.70-77


Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study

Author(s):  Jian-nong Wu, Tie-er Gan, Yue-xian Zhu, Jun-min Cao, Cong-hua Ji, Yi-hua Wu, Bin Lv

Affiliation(s):  Department of Hospital Infection Control, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China; more

Corresponding email(s):   lvbin@medmail.com.cn

Key Words:  Nosocomial bloodstream infection, Traditional Chinese medicine hospital, Epidemiology, Microbiology

Jian-nong Wu, Tie-er Gan, Yue-xian Zhu, Jun-min Cao, Cong-hua Ji, Yi-hua Wu, Bin Lv. Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study[J]. Journal of Zhejiang University Science B, 2015, 16(1): 70-77.

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author="Jian-nong Wu, Tie-er Gan, Yue-xian Zhu, Jun-min Cao, Cong-hua Ji, Yi-hua Wu, Bin Lv",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study
%A Jian-nong Wu
%A Tie-er Gan
%A Yue-xian Zhu
%A Jun-min Cao
%A Cong-hua Ji
%A Yi-hua Wu
%A Bin Lv
%J Journal of Zhejiang University SCIENCE B
%V 16
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%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400108

T1 - Epidemiology and microbiology of nosocomial bloodstream infections: analysis of 482 cases from a retrospective surveillance study
A1 - Jian-nong Wu
A1 - Tie-er Gan
A1 - Yue-xian Zhu
A1 - Jun-min Cao
A1 - Cong-hua Ji
A1 - Yi-hua Wu
A1 - Bin Lv
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 1
SP - 70
EP - 77
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400108

In many traditional Chinese medicine (TCM) hospitals, most patients are elderly with chronic diseases. nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. A retrospective surveillance study was performed to examine the epidemiology and microbiology of nBSIs in a TCM hospital from 2009 to 2011. A total of 482 patients with nBSIs were included in the study period. The incidence rate was 5.7/1000 admissions. Escherichia coli (25.5%) was the most common Gram-negative and coagulase-negative staphylococcus (CoNS) (14.1%) was the most common Gram-positive organism isolated. One-third of the E. coli and Klebsiella pneumoniae isolated from the nBSIs were the third-generation cephalosporin-resistant. Half of the Acinetobacter species isolates were resistant to imipenem. Of all the CoNS isolates, 90.7% were resistant to methicillin. Carbapenems and glycopeptide were the most frequently used for nBSI therapy. Only about one-third of patients (157/482) received appropriate empirical therapy. Septic shock, hemodialysis, Pitt bacteremia score >4, urinary tract infection, and appropriate empirical therapy were most strongly associated with 28-d mortality. The incidence of nBSIs was low in the TCM hospital but the proportion of nBSIs due to antibiotic-resistant organisms was high. A high Pitt bacteremia score was one of the most important risk factors for mortality in nBSIs. Therefore, the implementation of appropriate empirical therapy is crucial to improve the clinical outcome of nBSIs.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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