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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200587


Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet


Author(s):  Luhong SHEN, Yang YANG, Jiuliang ZHANG, Lanjie FENG, Qing ZHOU

Affiliation(s):  College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; more

Corresponding email(s):   zjl_ljz@mail.hzau.edu.cn, qingz_zqing@aliyun.com

Key Words:  Diacylated anthocyanins from purple sweet potato (diacylated AF-PSP), Hyperglycemia, Hyperuricemia, Metabolism syndrome, Renal function regulation


Luhong SHEN, Yang YANG, Jiuliang ZHANG, Lanjie FENG, Qing ZHOU. Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%T Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet
%A Luhong SHEN
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A1 - Luhong SHEN
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A1 - Lanjie FENG
A1 - Qing ZHOU
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DOI - 10.1631/jzus.B2200587


Abstract: 
Studies have shown that targeting xanthine oxidase (XO) can be a feasible treatment for fructose induced hyperuricemia and hyperglycemia. This study aimed to evaluate the dual regulatory effect and molecular mechanism of diacylated anthocyanins (diacylated AF-PSPs) from purple sweet potato on hyperglycemia and hyperuricemia induced by a high fructose/high fat diet. Results showed that diacylated AF-PSPs alleviated hyperuricemia in mice, and that this effect might be related to the regulation of liver XO activity, lipid accumulation and relevant renal transporters. Diacylated AF-PSPs reduced body weight and relieved lipid metabolism disorder, liver lipid accumulation and liver oxidative stress, thereby enhancing insulin utilization and sensitivity, lowering blood sugar, and reducing hyperglycemia in mice. Also, diacylated AF-PSPs restored mRNA levels related to renal fructose metabolism, and reduced kidney injury and inflammation. This study provided experimental evidence for the mechanisms of dual regulation of blood glucose and uric acid by diacylated AF-PSPs and their utilization as functional foods in the management of metabolic syndrome.

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