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Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet
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Luhong SHEN, Yang YANG, Jiuliang ZHANG, Lanjie FENG, Qing ZHOU. Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet",
author="Luhong SHEN, Yang YANG, Jiuliang ZHANG, Lanjie FENG, Qing ZHOU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200587"
}
%0 Journal Article
%T Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet
%A Luhong SHEN
%A Yang YANG
%A Jiuliang ZHANG
%A Lanjie FENG
%A Qing ZHOU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200587
TY - JOUR
T1 - Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high fructose/high fat diet
A1 - Luhong SHEN
A1 - Yang YANG
A1 - Jiuliang ZHANG
A1 - Lanjie FENG
A1 - Qing ZHOU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200587
Abstract: Studies have shown that targeting xanthine oxidase (XO) can be a feasible treatment for fructose induced hyperuricemia and hyperglycemia. This study aimed to evaluate the dual regulatory effect and molecular mechanism of diacylated anthocyanins (diacylated AF-PSPs) from purple sweet potato on hyperglycemia and hyperuricemia induced by a high fructose/high fat diet. Results showed that diacylated AF-PSPs alleviated hyperuricemia in mice, and that this effect might be related to the regulation of liver XO activity, lipid accumulation and relevant renal transporters. Diacylated AF-PSPs reduced body weight and relieved lipid metabolism disorder, liver lipid accumulation and liver oxidative stress, thereby enhancing insulin utilization and sensitivity, lowering blood sugar, and reducing hyperglycemia in mice. Also, diacylated AF-PSPs restored mRNA levels related to renal fructose metabolism, and reduced kidney injury and inflammation. This study provided experimental evidence for the mechanisms of dual regulation of blood glucose and uric acid by diacylated AF-PSPs and their utilization as functional foods in the management of metabolic syndrome.
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