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CLC number: TS275.4

On-line Access: 2016-02-01

Received: 2015-07-13

Revision Accepted: 2015-12-03

Crosschecked: 2015-12-16

Cited: 7

Clicked: 5564

Citations:  Bibtex RefMan EndNote GB/T7714


Wei Chen


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.2 P.147-157


Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice

Author(s):  Zhuo-ping Yu, Dong-dong Xu, Lai-feng Lu, Xiao-dong Zheng, Wei Chen

Affiliation(s):  College of Biosystems Engineering and Food Science, Fuli Institute of Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R&D Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   xdzheng@zju.edu.cn, zjuchenwei@zju.edu.cn

Key Words:  American ginseng, Chinese jujube, Immunomodulation, Antioxidant activity

Zhuo-ping Yu, Dong-dong Xu, Lai-feng Lu, Xiao-dong Zheng, Wei Chen. Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice[J]. Journal of Zhejiang University Science B, 2016, 17(2): 147-157.

@article{title="Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice",
author="Zhuo-ping Yu, Dong-dong Xu, Lai-feng Lu, Xiao-dong Zheng, Wei Chen",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice
%A Zhuo-ping Yu
%A Dong-dong Xu
%A Lai-feng Lu
%A Xiao-dong Zheng
%A Wei Chen
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 2
%P 147-157
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500170

T1 - Immunomodulatory effect of a formula developed from American ginseng and Chinese jujube extracts in mice
A1 - Zhuo-ping Yu
A1 - Dong-dong Xu
A1 - Lai-feng Lu
A1 - Xiao-dong Zheng
A1 - Wei Chen
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 2
SP - 147
EP - 157
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500170

Background: american ginseng (Panax quinquefolius L.) and chinese jujube (Zizyphus jujuba Mill.) are commonly used in traditional Chinese medicine to enhance immune function. Objective: The present study aimed to develop one Chinese prescription, Shenzao Cha (SZC), consisting of american ginseng and chinese jujube, and systematically investigate its immunomodulation in healthy ICR mice. Methods: Normal ICR mice received intragastric administration of SZC (1.3, 2.6, and 5.2 g raw material/kg body weight) once daily for four weeks, while a control group received the same amount of sterile water. Results: SZC significantly increased the spleen and thymus indices and T-lymphocyte proliferation, while the T-lymphocyte proliferation in the 5.2 g/kg group was 1.4-fold higher than that in the control. Further, 1.3 g/kg SZC could markedly improve hemolytic activity by 25.2%, and 2.6 g/kg SZC increased the NK cell activity by 78.6% relative to the control. In addition, the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase), that participated in modulating oxidative stress, were significantly increased in the liver, spleen, thymus, and serum, while the contents of malondialdehyde were dramatically decreased. Conclusions: SZC exhibited potent immunomodulatory effects on innate and adaptive immunity in healthy ICR mice, as well as potential antioxidant activity for prevention of oxidative stress, which was suggested to partly contribute to the immune enhancement.


方法:将西洋参与红枣提取物按一定比例制备复方制剂,以1.3、2.6和5.2 g/kg为低、中和高剂量给健康ICR小鼠连续灌胃此复方制剂4周,对照组灌胃同等剂量的无菌水,最后通过测定免疫相关指标对该复方制剂的免疫调节功能进行综合评价。


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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