Full Text:   <1626>

Summary:  <1546>

CLC number: R541.4

On-line Access: 2015-11-04

Received: 2015-08-30

Revision Accepted: 2015-10-26

Crosschecked: 2015-10-26

Cited: 1

Clicked: 3015

Citations:  Bibtex RefMan EndNote GB/T7714


Jian Liu


-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.11 P.924-930


Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS

Author(s):  Jian Liu, Zhao Wang, Wei-min Wang, Qi Li, Yu-liang Ma, Chuan-fen Liu, Ming-yu Lu, Hong Zhao

Affiliation(s):  Department of Cardiology, Peking University People’s Hospital, Beijing 100044, China

Corresponding email(s):   drjianliu@163.com, weiminwang@vip.sina.com

Key Words:  Acute coronary syndrome, Intravascular ultrasound, Unstable plaque

Jian Liu, Zhao Wang, Wei-min Wang, Qi Li, Yu-liang Ma, Chuan-fen Liu, Ming-yu Lu, Hong Zhao. Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS[J]. Journal of Zhejiang University Science B, 2015, 16(11): 924-930.

@article{title="Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS",
author="Jian Liu, Zhao Wang, Wei-min Wang, Qi Li, Yu-liang Ma, Chuan-fen Liu, Ming-yu Lu, Hong Zhao",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS
%A Jian Liu
%A Zhao Wang
%A Wei-min Wang
%A Qi Li
%A Yu-liang Ma
%A Chuan-fen Liu
%A Ming-yu Lu
%A Hong Zhao
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 11
%P 924-930
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500206

T1 - Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS
A1 - Jian Liu
A1 - Zhao Wang
A1 - Wei-min Wang
A1 - Qi Li
A1 - Yu-liang Ma
A1 - Chuan-fen Liu
A1 - Ming-yu Lu
A1 - Hong Zhao
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 11
SP - 924
EP - 930
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500206

Objective: To compare the plaque composition between stable and unstable plaques, characterize unstable plaque by using iMap-intravascular ultrasound (IVUS), and quantify the diagnostic criteria for unstable plaque. Methods: Thirty-three acute coronary syndrome (ACS) patients who had undergone coronary angiography and IVUS from February 19, 2014 to December 19, 2014 at Peking University People’s Hospital were enrolled in the study. Baseline data were collected. The patients were divided into two groups according to their gray-scale IVUS imaging, stable plaque and unstable plaque. A difference-in-difference evaluation was performed using the baseline data and off-line iMap imaging results between the two groups. A receiver operating characteristic (ROC) curve was constructed to obtain the optimal cut-off value to diagnose unstable plaque. Results: Percentages of fibrotic and necrotic tissues, absolute values of lipidic, necrotic, and calcified tissues, and plaque burden were independent predictors for unstable plaque. Absolute necrotic area was the best predictor and exhibited the highest diagnostic value for plaque vulnerability (area under the curve (AUC)=0.806, P=0.000, 95% CI (0.718, 0.894)). The cut-off score for predicting unstable plaque was 4.0 mm2. Conclusions: This study attempted to propose a cut-off value based on absolute necrotic area using iMap-IVUS to predict plaque vulnerability in patients with ACS. This score might provide a valuable reference for diagnosing unstable plaque.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Araki, T., Nakamura, M., Utsunomiya, M., et al., 2013. Visualization of coronary plaque in arterial remodeling using a new 40-MHz intravascular ultrasound imaging system. Catheter. Cardiovasc. Interv., 81(3):471-480.

[2]Burke, A.P., Farb, A., Malcom, G., et al., 1997. Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N. Engl. J. Med., 336(18):1276-1282.

[3]DeLong, E.R., DeLong, D.M., Clarke-Pearson, D.L., 1988. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics, 44(3):837-845.

[4]Despres, J.P., Lemieux, I., Prud'homme, D., 2001. Treatment of obesity: need to focus on high risk abdominally obese patients. BMJ, 322(7288):716-720.

[5]Fernández-Ortiz, A., Badimon, J.J., Falk, E., et al., 1994. Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture. J. Am. Coll. Cardiol., 23(7):1562-1569.

[6]König, A., Klauss, V., 2007. Virtual histology. Heart, 93(8):977-982.

[7]Kozuki, A., Shinke, T., Otake, H., et al., 2013. Feasibility of a novel radiofrequency signal analysis for in-vivo plaque characterization in humans: comparison of plaque components between patients with and without acute coronary syndrome. Int. J. Cardiol., 167(4):1591-1596.

[8]Nasu, K., Tsuchikane, E., Katoh, O., et al., 2008. Plaque characterization by Virtual Histology intravascular ultrasound analysis in type II diabetic patients. Heart, 94(4):429-433.

[9]Potkin, B.N., Bartorelli, A.L., Gessert, J.M., et al., 1990. Coronary artery imaging with intravascular high-frequency ultrasound. Circulation, 81(5):1575-1585.

[10]Sathyanarayana, S., Carlier, S., Li, W., et al., 2009. Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals. EuroIntervention, 5(1):133-139.

[11]Shin, E.S., Garcia-Garcia, H.M., Ligthart, J.M., et al., 2011. In vivo findings of tissue characteristics using iMap™ IVUS and Virtual Histology™ IVUS. EuroIntervention, 6(8):1017-1019.

[12]Stone, G.W., Maehara, A., Lansky, A.J., et al., 2011. A prospective natural-history study of coronary atherosclerosis. N. Engl. J. Med., 364(3):226-235.

[13]Trusinskis, K., Juhnevica, D., Strenge, K., et al., 2013. iMap intravascular ultrasound evaluation of culprit and non-culprit lesions in patients with ST-elevation myocardial infarction. Cardiovasc. Revasc. Med., 14(2):71-75.

[14]Yamada, R., Okura, H., Kume, T., et al., 2007. Histological characteristics of plaque with ultrasonic attenuation: a comparison between intravascular ultrasound and histology. J. Cardiol., 50(4):223-228.

[15]Yla-Herttuala, S., Palinski, W., Butler, S.W., et al., 1994. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler. Thromb. Vasc. Biol., 14(1):32-40.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE