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CLC number: R285.5

On-line Access: 2017-05-04

Received: 2016-08-09

Revision Accepted: 2017-01-15

Crosschecked: 2017-04-10

Cited: 2

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.5 P.445-448


Ginsenoside Rg1 promotes neural differentiation of mouse adipose-derived stem cells via the miRNA-124 signaling pathway

Author(s):  Juan Dong, Guo Zhu, Tian-cheng Wang, Fu-shan Shi

Affiliation(s):  Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   sfs@zju.edu.cn

Key Words:  Adipose-derived stem cells (ADSC), Ginsenoside Rg1, Surgical treatment

Juan Dong, Guo Zhu, Tian-cheng Wang, Fu-shan Shi. Ginsenoside Rg1 promotes neural differentiation of mouse adipose-derived stem cells via the miRNA-124 signaling pathway[J]. Journal of Zhejiang University Science B, 2017, 18(5): 445-448.

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publisher="Zhejiang University Press & Springer",

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%T Ginsenoside Rg1 promotes neural differentiation of mouse adipose-derived stem cells via the miRNA-124 signaling pathway
%A Juan Dong
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T1 - Ginsenoside Rg1 promotes neural differentiation of mouse adipose-derived stem cells via the miRNA-124 signaling pathway
A1 - Juan Dong
A1 - Guo Zhu
A1 - Tian-cheng Wang
A1 - Fu-shan Shi
J0 - Journal of Zhejiang University Science B
VL - 18
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SP - 445
EP - 448
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600355

We have explored the role of ginsenoside Rg1 in promoting the differentiation of mouse adipose-derived stem cells (mADSC) towards the neuronal lineage. The central nervous system has long been regarded as incapable of self-repair; therefore neuronal differentiation from stem cells is of great interest. However, the use of embryonic stem cells is limited due to their inaccessibility and for ethical reasons, so the search is on for alternative pluripotent cells capable of differentiating into neuronal cells. adipose-derived stem cells (ADSC) can differentiate into different cell types, including neuronal cells: their accessibility, low risk, and capacity for long-term growth and self-renewal have made them the preferred stem cell type for clinical applications. Several methods have been indicated for promoting the neuronal differentiation of ADSC, but the mechanism of this process has not been clearly identified. As our previous study showed that microRNA-124 (miRNA-124) plays a positive role in promoting the neural differentiation of ADSC, we wanted to find reagents that can upregulate miRNA-124 expression during neural differentiation.




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