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CLC number: R969.3

On-line Access: 2018-06-04

Received: 2017-06-20

Revision Accepted: 2018-01-25

Crosschecked: 2018-05-14

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Citations:  Bibtex RefMan EndNote GB/T7714


Chen-guang Ding


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.6 P.481-489


Outcomes of EC-MPS combined with low-dose tacrolimus in DCD kidney transplantation for high-risk DGF recipients

Author(s):  Li-zi Jiao, Chen-guang Ding, Pu-xun Tian, Xiao-ming Ding, Xiao-ming Pan, He-li Xiang, Xiao-hui Tian, Yang Li, Jin Zheng, Wu-jun Xue

Affiliation(s):  Department of Kidney Transplantation, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China; more

Corresponding email(s):   doctor_ding@126.com, xwujun@126.com

Key Words:  Enteric-coated mycophenolate sodium (EC-MPS), Tacrolimus, Delayed graft function (DGF), Donation after cardiac death (DCD), Kidney transplantation

Li-zi Jiao, Chen-guang Ding, Pu-xun Tian, Xiao-ming Ding, Xiao-ming Pan, He-li Xiang, Xiao-hui Tian, Yang Li, Jin Zheng, Wu-jun Xue. Outcomes of EC-MPS combined with low-dose tacrolimus in DCD kidney transplantation for high-risk DGF recipients[J]. Journal of Zhejiang University Science B, 2018, 19(6): 481-489.

@article{title="Outcomes of EC-MPS combined with low-dose tacrolimus in DCD kidney transplantation for high-risk DGF recipients",
author="Li-zi Jiao, Chen-guang Ding, Pu-xun Tian, Xiao-ming Ding, Xiao-ming Pan, He-li Xiang, Xiao-hui Tian, Yang Li, Jin Zheng, Wu-jun Xue",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Outcomes of EC-MPS combined with low-dose tacrolimus in DCD kidney transplantation for high-risk DGF recipients
%A Li-zi Jiao
%A Chen-guang Ding
%A Pu-xun Tian
%A Xiao-ming Ding
%A Xiao-ming Pan
%A He-li Xiang
%A Xiao-hui Tian
%A Yang Li
%A Jin Zheng
%A Wu-jun Xue
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 6
%P 481-489
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700315

T1 - Outcomes of EC-MPS combined with low-dose tacrolimus in DCD kidney transplantation for high-risk DGF recipients
A1 - Li-zi Jiao
A1 - Chen-guang Ding
A1 - Pu-xun Tian
A1 - Xiao-ming Ding
A1 - Xiao-ming Pan
A1 - He-li Xiang
A1 - Xiao-hui Tian
A1 - Yang Li
A1 - Jin Zheng
A1 - Wu-jun Xue
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 6
SP - 481
EP - 489
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700315

Effective use of immunosuppressive agents to avoid the occurrence of nephrotoxicity and rejection in recipients with delayed graft function (DGF) is a concern for physicians. We investigated the outcomes of treatment with enteric-coated mycophenolate sodium (EC-MPS) in combination with a low-dose of tacrolimus (Tac) in renal transplantation for recipients with a high risk of DGF. We conducted a retrospective study of 61 recipients with a high risk of DGF who were treated with EC-MPS and low-dose Tac. The recipients were separated into a no-DGF group and a DGF group, based on whether DGF actually occurred. The results showed that although EC-MPS and Tac doses were similar in both groups, the percentage of recipients whose mycophenolic acid area under the curve 0–12 h (MPA-AUC0–12 h) was below 30 (mg·h)/L was significantly higher and the Tac trough concentration significantly lower in the DGF group one week after transplantation. Notably, a higher incidence of biopsy-proven acute rejection (BPAR) was found in the DGF group and among all recipients whose MPA-AUC0–12 h was less than 30 (mg·h)/L at one week after transplantation. One-year graft survival, patient survival, allograft function, and the incidence of the most common adverse events were similar in the two groups. In conclusion, the immunosuppressive regime is applicable to Chinese kidney transplant recipients, and early low exposure to EC-MPS was related to acute rejection in the recipients at a high risk of DGF.

DCD肾移植中DGF高风险受者应用EC-MPS 联合低剂量他克莫司治疗的预后分析

结论:DGF组及正常恢复组间米芙及他克莫司剂量无显著差异.术后1周DGF组EC-MPS血药浓度曲线下面积小于30 (mg·h)/L的比率显著高于正常恢复组,同时他克莫司谷浓度显著低于正常恢复组,DGF组经活检证实的急排反应的发生率显著高于正常恢复组,术后1周的EC-MPS血药浓度曲线下面积低于30 (mg·h)/L的受者中经活检证实的急排反应的发生率显著高于其他受者.1年移植物存活率、移植物功能及常见不良反应在两组间未见明显差异.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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