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CLC number: Q493.9

On-line Access: 2018-09-30

Received: 2017-09-17

Revision Accepted: 2018-02-07

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.10 P.764-775


Assessment of anti-diabetic activity of peanut shell polyphenol extracts

Author(s):  Xiao-Meng Sun, Hai-Qing Ye, Jing-Bo Liu, Lei Wu, Ding-Bo Lin, Ya-Li Yu, Feng Gao

Affiliation(s):  Department of Food Science and Engineering, College of Food Science and Engineering, Jilin University, Changchun 130062, China; more

Corresponding email(s):   yyl_0927@163.com, g_f@jlu.edu.cn

Key Words:  Peanut shell polyphenol extract (PSPE), Anti-diabetic activity, Streptozotocin (STZ)

Xiao-Meng Sun, Hai-Qing Ye, Jing-Bo Liu, Lei Wu, Ding-Bo Lin, Ya-Li Yu, Feng Gao. Assessment of anti-diabetic activity of peanut shell polyphenol extracts[J]. Journal of Zhejiang University Science B, 2018, 19(10): 764-775.

@article{title="Assessment of anti-diabetic activity of peanut shell polyphenol extracts",
author="Xiao-Meng Sun, Hai-Qing Ye, Jing-Bo Liu, Lei Wu, Ding-Bo Lin, Ya-Li Yu, Feng Gao",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Assessment of anti-diabetic activity of peanut shell polyphenol extracts
%A Xiao-Meng Sun
%A Hai-Qing Ye
%A Jing-Bo Liu
%A Lei Wu
%A Ding-Bo Lin
%A Ya-Li Yu
%A Feng Gao
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 10
%P 764-775
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700401

T1 - Assessment of anti-diabetic activity of peanut shell polyphenol extracts
A1 - Xiao-Meng Sun
A1 - Hai-Qing Ye
A1 - Jing-Bo Liu
A1 - Lei Wu
A1 - Ding-Bo Lin
A1 - Ya-Li Yu
A1 - Feng Gao
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 10
SP - 764
EP - 775
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700401

The present study aimed to evaluate the anti-diabetic property of peanut shell polyphenol extracts (PSPEs). Diabetic rats were oral-administrated with PSPE at doses of 50, 100, and 200 mg/kg body weight (BW) per day for 28 consecutive days, with metformin (Met) as a positive control. The results showed that, similar to the Met treatment, administration of PSPE caused significant decreases in food intake, water intake, fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and methane dicarboxylic aldehyde in serum, and significant increases in BW, insulin level, high-density lipoprotein cholesterol, superoxide dismutase, glutathione, and liver glycogen. Further, glucose tolerance was markedly improved in the PSPE-treated diabetic groups. Histopathological results showed that PSPE improved cellular structural and pathological changes in liver, kidney, and pancreatic islets. Collectively, the results indicated that the hypoglycemic effects of PSPE on high-fat diet/streptozotocin (HFD/STZ)-induced diabetes are comparable to Met, though their exact mechanism actions are still under investigation. Therefore, the current study suggests that PSPE could be a potential health-care food supplement in the management of diabetes.


方法:通过高脂饮食/链脲霉素(HFD/STZ)诱导产生糖尿病小鼠.将糖尿病小鼠随机分为四组:二甲双胍组、花生壳多酚高、中、低剂量组(分别为200、100和50 mg/kg);同时设置正常对照组及糖尿病对照组.二甲双胍及花生壳多酚每日口服一次,剂量为每天10 ml/kg 体重,持续4周;考察不同剂量的花生壳多酚对糖尿病小鼠的体重、饮食、饮水,空腹血糖、血清总胆固醇、血脂、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇,及血液中超氧化物歧化酶、谷胱甘肽、丙二醛、肝糖原水平的影响;并对小鼠的肝脏、肾脏和胰岛组织进行组织学分析.


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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