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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200590


In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts


Author(s):  Jing Wang, Xingyu Zhao, Jiawei Zheng, Daniela D. Herrera-Balandrano, Xiaoxiao Zhang, Wuyang Huang, Zhongquan Sui

Affiliation(s):  College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China; more

Corresponding email(s):   wuyanghuang@hotmail.com, zsui@sjtu.edu.cn

Key Words:  Blueberry anthocyanins, In vivo antioxidant activity, SOD, GSH-PX, MDA


Jing Wang, Xingyu Zhao, Jiawei Zheng, Daniela D. Herrera-Balandrano, Xiaoxiao Zhang, Wuyang Huang, Zhongquan Sui. In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%T In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. ‘Brightwell’) anthocyanin extracts
%A Jing Wang
%A Xingyu Zhao
%A Jiawei Zheng
%A Daniela D. Herrera-Balandrano
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%A Zhongquan Sui
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A1 - Daniela D. Herrera-Balandrano
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A1 - Wuyang Huang
A1 - Zhongquan Sui
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Abstract: 
Blueberries are rich in phenolic compounds including anthocyanins which are closely related to biological health functions. The purpose of this study was to investigate the antioxidant activity of blueberry anthocyanins extracted from ‘Brightwell’ rabbiteye blueberries in mice. After one week of adaptation, C57BL/6J healthy male mice were divided into different groups that were administered with 100, 400, or 800 mg/kg BAE (blueberry anthocyanin extract), and sacrificed at different time points (0.1, 0.5, 1, 2, 4, 8, or 12 h). The plasma, eyeballs, intestines, liver, and adipose tissues were collected to compare their antioxidant activities, including total antioxidant capacity (T-AOC), the antioxidant enzymes superoxide dismutase (SOD) and glutathione-peroxidase (GSH-PX or GPX), and the oxidative stress marker malondialdehyde (MDA). The results showed that blueberry anthocyanins had positive concentration-dependent antioxidant activity in vivo. The greater the blueberry anthocyanin concentration, the higher the T-AOC values, but the lower the MDA levels. The enzyme activity of SOD, the content of GSH-PX, and mRNA levels of Cu,Zn-SOD, Mn-SOD, and GPX all confirmed BAE played an antioxidant role after digestion in mice by improving their antioxidant defense. The In vivo antioxidant activity of BAE indicated that blueberry anthocyanins could be developed into functional foods or nutraceuticals with the aim of preventing or treating oxidative stress-related diseases.

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