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Xian-Feng Ding

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.9 P.673-689

http://doi.org/10.1631/jzus.B1900709


Roles of miRNA and lncRNA in triple-negative breast cancer


Author(s):  Juan Xu, Kang-Jing Wu, Qiao-Jun Jia, Xian-Feng Ding

Affiliation(s):  College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China

Corresponding email(s):   bdd114@163.com

Key Words:  Biomarker, Long non-coding RNA (lncRNA), MicroRNA, Regulation mechanism, Triple-negative breast cancer (TNBC)


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Juan Xu, Kang-Jing Wu, Qiao-Jun Jia, Xian-Feng Ding. Roles of miRNA and lncRNA in triple-negative breast cancer[J]. Journal of Zhejiang University Science B, 2020, 21(9): 673-689.

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%DOI 10.1631/jzus.B1900709

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DOI - 10.1631/jzus.B1900709


Abstract: 
triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast cancer without effective targeted therapies, which makes its pathogenesis an important target for research. A growing number of studies have shown that non-coding RNA (ncRNA), including microRNA (miRNA) and long non-coding RNA (lncRNA), plays a significant role in tumorigenesis. This review summarizes the roles of miRNA and lncRNA in the progression, diagnosis, and neoadjuvant chemotherapy of TNBC. Aberrantly expressed miRNA and lncRNA are listed according to their roles. Further, it describes the multiple mechanisms that lncRNA shows for regulating gene expression in the nucleus and cytoplasm, and more importantly, describes lncRNA-regulated TNBC progression through complete combining with miRNA at the post-transcriptional level. Focusing on miRNA and lncRNA associated with TNBC can provide new insights for early diagnosis and treatment—they can be targeted in the future as a novel anticancer target of TNBC.

miRNA和lncRNA在三阴性乳腺癌中的作用

概要:三阴性乳腺癌(TNBC)作为乳腺癌中最恶性的亚型,具有异质性高、增殖能力高、转移性强等特点,且缺乏有效的靶向治疗,因而其发病机制成为研究的重点.越来越多的研究表明,小RNA (miRNA)和长链非编码RNA(lncRNA)在内的非编码RNA在肿瘤的发生和发展中起着重要的作用.本文总结归纳了近些年来与TNBC相关的miRNA和lncRNA,介绍了lncRNA调节基因表达的多种机制,概述了miRNA和lncRNA在TNBC进展、诊断以及新辅助化疗中的作用.本文探索miRNA和lncRNA与TNBC的关系,旨在为癌症的早期诊断和治疗提供新思路,使其成为治疗癌症的新靶点.
关键词:生物标志物;长链非编码RNA(lncRNA);小RNA(miRNA);调节机制;三阴性乳腺癌(TNBC)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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