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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.10 P.781-792

http://doi.org/10.1631/jzus.B1900073


Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases


Author(s):  Er-Teng Jia, Zhi-Yu Liu, Min Pan, Jia-Feng Lu, Qin-Yu Ge

Affiliation(s):  State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China; more

Corresponding email(s):   geqinyu@seu.edu.cn

Key Words:  Gut microbiota, Bile acid, Farnesoid X receptor, Vitamin D receptor, Metabolism


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Er-Teng Jia, Zhi-Yu Liu, Min Pan, Jia-Feng Lu, Qin-Yu Ge. Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases[J]. Journal of Zhejiang University Science B, 2019, 20(10): 781-792.

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pages="781-792",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900073"
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%A Er-Teng Jia
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%J Journal of Zhejiang University SCIENCE B
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%DOI 10.1631/jzus.B1900073

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T1 - Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases
A1 - Er-Teng Jia
A1 - Zhi-Yu Liu
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J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900073


Abstract: 
Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial–host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.

肠道微生物调节疾病中胆汁酸代谢相关的信号通路

概要:近十年来,微生物与胆汁酸代谢的相互作用越来越受到关注.胆汁酸不仅参与营养物质的代谢,而且在调节宿主生理活动的信号转导中也起着重要作用.已有研究表明,微生物调控的胆汁酸代谢对许多疾病都有显著的影响,但对微生物受体信号通路调控疾病的相关研究并不多.本文综述了近年来有关法尼醇受体(FXR)、G蛋白偶联胆汁酸受体(TGR5)和维生素D受体(VDR)信号通路在健康和疾病的微生物-宿主相互作用中的核心作用.研究这些信号通路之间的关系,有助于我们了解人类疾病的发病机制,为人类疾病的治疗提供新的解决方案.
关键词:肠道微生物群;胆汁酸;法尼醇受体;维生素D受体;代谢

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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