CLC number: Q28
On-line Access: 2019-05-15
Received: 2019-04-13
Revision Accepted: 2019-04-24
Crosschecked: 2019-05-09
Cited: 0
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Su-Wei Gao, Feng Liu. Novel insights into cell cycle regulation of cell fate determination[J]. Journal of Zhejiang University Science B, 2019, 20(6): 467-475.
@article{title="Novel insights into cell cycle regulation of cell fate determination",
author="Su-Wei Gao, Feng Liu",
journal="Journal of Zhejiang University Science B",
volume="20",
number="6",
pages="467-475",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900197"
}
%0 Journal Article
%T Novel insights into cell cycle regulation of cell fate determination
%A Su-Wei Gao
%A Feng Liu
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 6
%P 467-475
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900197
TY - JOUR
T1 - Novel insights into cell cycle regulation of cell fate determination
A1 - Su-Wei Gao
A1 - Feng Liu
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 6
SP - 467
EP - 475
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900197
Abstract: The stem/progenitor cell has long been regarded as a central cell type in development, homeostasis, and regeneration, largely owing to its robust self-renewal and multilineage differentiation abilities. The balance between self-renewal and stem/progenitor cell differentiation requires the coordinated regulation of cell cycle progression and cell fate determination. Extensive studies have demonstrated that cell cycle states determine cell fates, because cells in different cell cycle states are characterized by distinct molecular features and functional outputs. Recent advances in high-resolution epigenome profiling, single-cell transcriptomics, and cell cycle reporter systems have provided novel insights into the cell cycle regulation of cell fate determination. Here, we review recent advances in cell cycle-dependent cell fate determination and functional heterogeneity, and the application of cell cycle manipulation for cell fate conversion. These findings will provide insight into our understanding of cell cycle regulation of cell fate determination in this field, and may facilitate its potential application in translational medicine.
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