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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2400127


Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes


Author(s):  Qi-Hua HUA, Xuechun ZHANG, Ruifeng TIAN, Zhigang SHE, Zan HUANG

Affiliation(s):  College of Life Sciences, Key Laboratory of Cell Homeostasis of Hubei Province, Wuhan University, Wuhan 430060, China; more

Corresponding email(s):   z-huang@whu.edu.cn

Key Words:  Polyploidy, Endomitosis, Megakaryocyte, Hepatocyte, Cell Cycle, Tetraploidy Checkpoint, Whole-genome Doubling


Qi-Hua HUA, Xuechun ZHANG, Ruifeng TIAN, Zhigang SHE, Zan HUANG. Endomitosis: a new cell fate in the cell cycle leading to polyploidy in megakaryocytes and hepatocytes[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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A1 - Zan HUANG
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Abstract: 
megakaryocytes and hepatocytes are unique cells in mammals that undergo polyploidization through endomitosis in terminal differentiation. Many polyploidization regulators and underlying mechanisms have been reported, most of which are tightly coupled with development, organogenesis, and cell differentiation. However, the nature of endomitosis, which involves successful entry into and exit from mitosis without complete cytokinesis, has not been fully elucidated yet. We highlight that endomitosis is a new cell fate in the cell Cycle, and tetraploidy is a critical stage at the bifurcation of cell fate decision. This review will summarize the recent research progress in this area and provide novel insights into how cells manipulate mitosis toward endomitosis. Endomitotic cells can evade the tetraploidy restrictions and proceed to multiple rounds of the cell Cycle. This knowledge not only deepens our understanding of endomitosis as a fundamental biological process but also offers new perspectives on the physiological and pathophysiological implications of polyploidization.

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