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On-line Access: 2019-09-06

Received: 2019-04-28

Revision Accepted: 2019-07-15

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.10 P.849-860


Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation

Author(s):  Bing Hao, Song Gao, Yi-Wen Sang, Lin Wang, Xue-Qin Meng, Jing-Ya You

Affiliation(s):  National Health Commission (NHC) Key Laboratory of Combined Multi-organ Transplantation, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   haobing79@zju.edu.cn

Key Words:  Autoantibody, Chronic graft-versus-host disease (cGVHD), Anti-Ro52

Bing Hao, Song Gao, Yi-Wen Sang, Lin Wang, Xue-Qin Meng, Jing-Ya You. Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation[J]. Journal of Zhejiang University Science B, 2019, 20(10): 849-860.

@article{title="Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation",
author="Bing Hao, Song Gao, Yi-Wen Sang, Lin Wang, Xue-Qin Meng, Jing-Ya You",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation
%A Bing Hao
%A Song Gao
%A Yi-Wen Sang
%A Lin Wang
%A Xue-Qin Meng
%A Jing-Ya You
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 10
%P 849-860
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900205

T1 - Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation
A1 - Bing Hao
A1 - Song Gao
A1 - Yi-Wen Sang
A1 - Lin Wang
A1 - Xue-Qin Meng
A1 - Jing-Ya You
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 10
SP - 849
EP - 860
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900205

We investigated the value of autoantibodies as biomarkers of chronic graft-versus-host disease (cGVHD) by analyzing the autoantibody profiles of 65 patients (34 cGVHD and 31 non-cGVHD) surviving longer than three months after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Autoantibodies to at least one antigen were detected in 45 patients (70.8%), with multiple autoantibodies detected in 30 patients (46.2%). Antinuclear antibodies (ANAs) were the most frequently detected autoantibodies, with a significantly higher prevalence in non-cGVHD patients and cGVHD patients than that in healthy controls (HCs). ANA-nucleolar (ANA-N) was the main immunofluorescence pattern of ANA-positivity in both the non-cGVHD and cGVHD groups. There was a higher prevalence of anti-Ro52-positivity in non-cGVHD and cGVHD patients than in HC. Liver cGVHD was significantly associated with anti-Ro52-positivity. However, cGVHD activity and severity were not associated with the presence of autoantibodies. Similarly, there were no significant differences in overall survival or relapse among the four groups of patients expressing autoantibodies. Our results suggest that autoantibodies have limited value in predicting cGVHD.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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