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CLC number: R735.3+4

On-line Access: 2019-10-09

Received: 2019-04-22

Revision Accepted: 2019-08-06

Crosschecked: 2019-09-12

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.933-939

http://doi.org/10.1631/jzus.B1900210


Difference in survival between right- versus left-sided colorectal neuroendocrine neoplasms


Author(s):  Ge-Han Xu, Hua-Wei Zou, Ashley B. Grossman

Affiliation(s):  The Second Clinical College of China Medical University, Shenyang 110004, China; more

Corresponding email(s):   zhw20181102@sina.com

Key Words:  Acrolein, Reactive carbonyl species, Ferulic acid, Cytotoxicity, Oxidative stress


Ge-Han Xu, Hua-Wei Zou, Ashley B. Grossman. Difference in survival between right- versus left-sided colorectal neuroendocrine neoplasms[J]. Journal of Zhejiang University Science B, 2019, 20(11): 933-939.

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%A Ashley B. Grossman
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T1 - Difference in survival between right- versus left-sided colorectal neuroendocrine neoplasms
A1 - Ge-Han Xu
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A1 - Ashley B. Grossman
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900210


Abstract: 
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors that arise from neuroendocrine cells, and in some cases are capable of producing agents that may cause characteristic hormonal syndromes (Cives and Strosberg, 2018). Such tumors were previously thought to be rare, but the rate of detection of NENs, especially from the gastrointestinal tract, is increasing with the widespread use of colonoscopy, cross-sectional imaging, and biomarkers (Gu et al., 2019). A study based on the Surveillance, Epidemiology, and End Results (SEER) database showed that the age-adjusted incidence of NENs increased 6.4-fold from 1973 (1.09 per 100 000) to 2012 (6.98 per 100 000) (Dasari et al., 2017), while there was a progressive increase in the incidence of colorectal NENs (Starzyńska et al., 2017).

左右半结直肠神经内分泌肿瘤的生存差异研究

目的:研究不同分期下左右半结直肠神经内分泌肿瘤(NEN)的生存差异.
创新点:左右半结直肠腺癌的生存差异已得到深入研究,而结直肠NEN作为一罕见病理类型,其左右半的生存差异尚缺乏研究.本研究旨在明确这一问题.
方法:选取SEER数据库中1988~2014年经病理确诊的结直肠NEN患者进行回顾性研究.多因素Cox回归分析比较左右半结直肠NEN的生存差异.
结论:相比于左半结直肠NEN,右半结肠NEN具有显著升高的死亡风险.而直肠与盲肠NEN是不同分期下左右半结直肠NEN生存差异的主要影响因素.

关键词:神经内分泌肿瘤;结直肠;生存

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Benson AB III, Venook AP, Cederquist L, et al., 2017. Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw, 15(3):370-398.

[2]Cesar D, Zanatto RM, da Silva MV, et al., 2013. Colon and rectum neuroendocrine tumors: experience of the National Cancer Institute in Brazil. Arq Bras Cir Dig, 26(1): 36-39.

[3]Cives M, Strosberg JR, 2018. Gastroenteropancreatic neuroendocrine tumors. CA Cancer J Clin, 68(6):471-487.

[4]Clark OH, Benson AB III, Berlin JD, et al., 2009. NCCN clinical practice guidelines in oncology: neuroendocrine tumors. J Natl Compr Canc Netw, 7(7):712-747.

[5]Dasari A, Shen C, Halperin D, et al., 2017. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol, 3(10):1335-1342.

[6]Garcia-Carbonero R, Sorbye H, Baudin E, et al., 2016. ENETS consensus guidelines for high-grade gastroenteropancreatic neuroendocrine tumors and neuroendocrine carcinomas. Neuroendocrinology, 103(2):186-194.

[7]Gu Q, Lin YM, Cen L, et al., 2019. Endoscopic ultrasonography is useful in the diagnosis and treatment of rectal neuroendocrine neoplasms: a case series. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 20(10):861-864.

[8]Jernvall P, Mäkinen MJ, Karttunen TJ, et al., 1999. Microsatellite instability: impact on cancer progression in proximal and distal colorectal cancers. Eur J Cancer, 35(2): 197-201.

[9]Meguid RA, Slidell MB, Wolfgang CL, et al., 2008. Is there a difference in survival between right- versus left-sided colon cancers? Ann Surg Oncol, 15(9):2388-2394.

[10]Mik M, Berut M, Dziki L, et al., 2017. Right- and left-sided colon cancer—clinical and pathological differences of the disease entity in one organ. Arch Med Sci, 13(1):157-162.

[11]Mitry E, Baudin E, Ducreux M, et al., 1999. Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin. Br J Cancer, 81(8):1351-1355.

[12]Modlin IM, Lye KD, Kidd M, 2003. A 5-decade analysis of 13,715 carcinoid tumors. Cancer, 97(4):934-959.

[13]Patta A, Fakih M, 2011. First-line cisplatin plus etoposide in high-grade metastatic neuroendocrine tumors of colon and rectum (MCRC NET): review of 8 cases. Anticancer Res, 31(3):975-978.

[14]Popat S, Hubner R, Houlston RS, 2005. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol, 23(3):609-618.

[15]Portale TR, Branca A, Pesce A, et al., 2012. Neuroendocrine carcinoma of colon and rectum: a rare neoplasia with a poor prognosis. Minerva Chir, 67(3):283-284.

[16]Price TJ, Beeke C, Ullah S, et al., 2015. Does the primary site of colorectal cancer impact outcomes for patients with metastatic disease? Cancer, 121(6):830-835.

[17]Sahnane N, Furlan D, Monti M, et al., 2015. Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity. Endocr Relat Cancer, 22(1): 35-45.

[18]Snaebjornsson P, Jonasson L, Jonsson T, et al., 2010. Colon cancer in Iceland—a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. Int J Cancer, 127(11): 2645-2653.

[19]Starzyńska T, Deptała A, Królicki L, et al., 2013. Colorectal neuroendocrine neoplasms—management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol, 64(6):494-504.

[20]Starzyńska T, Londzin-Olesik M, Bałdys-Waligórska A, et al., 2017. Colorectal neuroendocrine neoplasms—management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol, 68(2):250-260.

[21]Yao JC, Hassan MM, Phan A, et al., 2008. One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol, 26(18):3063-3072

[22]List of electronic supplementary materials

[23]Table S1 Multivariable Cox regression of independent variables for cancer-specific risk of death

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