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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.204-217


Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance

Author(s):  Er-Rong Du, Rong-Ping Fan, Li-Lou Rong, Zhen Xie, Chang-Shui Xu

Affiliation(s):  Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, China; more

Corresponding email(s):   xuchangshui@ncu.edu.cn

Key Words:  Microglia, Neuropathic pain (NPP), Morphine tolerance, Microglial inhibitor

Er-Rong Du, Rong-Ping Fan, Li-Lou Rong, Zhen Xie, Chang-Shui Xu. Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance[J]. Journal of Zhejiang University Science B, 2020, 21(3): 204-217.

@article{title="Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance",
author="Er-Rong Du, Rong-Ping Fan, Li-Lou Rong, Zhen Xie, Chang-Shui Xu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance
%A Er-Rong Du
%A Rong-Ping Fan
%A Li-Lou Rong
%A Zhen Xie
%A Chang-Shui Xu
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 3
%P 204-217
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900425

T1 - Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance
A1 - Er-Rong Du
A1 - Rong-Ping Fan
A1 - Li-Lou Rong
A1 - Zhen Xie
A1 - Chang-Shui Xu
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 3
SP - 204
EP - 217
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900425

microglia are important cells involved in the regulation of neuropathic pain (NPP) and morphine tolerance. Information on their plasticity and polarity has been elucidated after determining their physiological structure, but there is still much to learn about the role of this type of cell in NPP and morphine tolerance. microglia mediate multiple functions in health and disease by controlling damage in the central nervous system (CNS) and endogenous immune responses to disease. microglial activation can result in altered opioid system activity, and NPP is characterized by resistance to morphine. Here we investigate the regulatory mechanisms of microglia and review the potential of microglial inhibitors for modulating NPP and morphine tolerance. Targeted inhibition of glial activation is a clinically promising approach to the treatment of NPP and the prevention of morphine tolerance. Finally, we suggest directions for future research on microglial inhibitors.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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