Full Text:   <2671>

CLC number: R775.3

On-line Access: 2012-09-04

Received: 2012-04-26

Revision Accepted: 2012-07-29

Crosschecked: 2012-08-19

Cited: 5

Clicked: 4934

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.9 P.723-730


Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber

Author(s):  Bing-hong Wang, Yu-feng Yao

Affiliation(s):  Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   yaoyuf@mail.hz.zj.cn

Key Words:  Iris and ciliary body cyst, Ultrasound biomicroscope, Shallow anterior chamber

Bing-hong Wang, Yu-feng Yao. Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber[J]. Journal of Zhejiang University Science B, 2012, 13(9): 723-730.

@article{title="Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber",
author="Bing-hong Wang, Yu-feng Yao",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber
%A Bing-hong Wang
%A Yu-feng Yao
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 9
%P 723-730
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200124

T1 - Effect of primary iris and ciliary body cyst on anterior chamber angle in patients with shallow anterior chamber
A1 - Bing-hong Wang
A1 - Yu-feng Yao
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 9
SP - 723
EP - 730
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200124

Objective: To evaluate the prevalence of primary iris and/or ciliary body cysts in eyes with shallow anterior chamber and their effect on the narrowing of the anterior chamber angle. Methods: Among the general physical check-up population, subjects with shallow anterior chambers, as judged by van Herick technique, were recruited for further investigation. ultrasound biomicroscope (UBM) was used to detect and measure the cysts located in the iris and/or ciliary body, the anterior chamber depth (ACD), the angle opening distance at 500 µm (AOD500), and the trabecular-iris angle (TIA). A-scan ultrasonography was used to measure the ocular biometry, including lens thickness, axial length, lens/axial length factor (LAF), and relative lens position (RLP). The effect of the cyst on narrowing the corresponding anterior chamber angle and the entire angle was evaluated by the UBM images, ocular biometry, and gonioscopic grading. The eye with unilateral cyst was compared with the eye without the cyst for further analysis. Results: Among the 727 subjects with shallow anterior chamber, primary iris and ciliary body cysts were detected in 250 (34.4%) patients; among them 96 (38.4%) patients showed unilateral single cyst, 21 (8.4%) patients had unilateral double cysts, and 42 (16.8%) patients manifested unilateral multiple and multi-quadrants cysts. Plateau iris configuration was found in 140 of 361 (38.8%) eyes with cysts. The mean size of total cysts was (0.6547±0.2319) mm. In evaluation of the effect of the cyst size and location on narrowing the corresponding angle to their position, the proportion of the cysts causing corresponding angle narrowing or closure among the cysts larger than 0.8 mm (113/121, 93.4%) was found to be significantly higher than that of the cysts smaller than 0.8 mm (373/801, 46.6%), and a significant higher proportion was also found in the cysts located at iridociliary sulcus (354/437, 81.0%) than in that at the pars plicata (131/484, 27.1%). In evaluating the effect of the cyst on the entire anterior chamber angle, the eyes with multiple and multi-quadrants cysts manifested significant narrowing of the entire anterior chamber angle as compared with the eyes without cysts, based on the data analysis in comparison of TIA, AOD500, and gonioscopic grading evaluation. The unilateral single or double cysts in the eyes had no significant effect on narrowing of anterior chamber angle as compared with eyes without cysts. The iris and/or ciliary body cysts did not seem to affect the axial length, ACD, lens thickness, RLP, LAF. Conclusions: The prevalence of primary iris and ciliary body cyst was 34.4% in the subjects with shallow anterior chamber. The cysts larger than 0.8 mm, locating at iridociliary sulcus, or multiple and extensive cysts were inclined to cause the angle narrowing or closure.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]Ang, G.S., Bochmann, F., Azuara-Blanco, A., 2008. Argon laser peripheral iridoplasty for plateau iris associated with iridociliary cysts: a case report. Cases J., 1(1):368.

[2]Azuara-Blanco, A., Spaeth, G.L., Araujo, S.V., Augsburger, J.J., Terebuh, A.K., 1996. Plateau iris syndrome associated with multiple ciliary body cysts. Report of three cases. Arch. Ophthalmol., 114(6):666-668.

[3]Badlani, V.K., Quinones, R., Wilensky, J.T., Hawkins, A., Edward, D.P., 2003. Angle-closure glaucoma in teenagers. J. Glaucoma, 12(3):198-203.

[4]Conway, R.M., Chew, T., Golchet, P., Desai, K., Lin, S., O′Brien, J., 2005. Ultrasound biomicroscopy: role in diagnosis and for anterior segment tumours management in 130 consecutive patients evaluated. Br. J. Opthalmol., 89(8):950-955.

[5]Crowston, J.G., Medeiros, F.A., Mosaed, S., Weinreb, R.N., 2005. Argon laser iridoplasty in the treatment of plateau-like iris configuration as result of numerous ciliary body cysts. Am. J. Ophthalmol., 139(2):381-383.

[6]Dada, T., Gadia, R., Sharma, A., Ichhpujani, P., Bali, S.J., Bhartiya, S., Panda, A., 2011. Ultrasound biomicroscopy in glaucoma. Surv. Ophthalmol., 56(5):433-450.

[7]Dorairaj, S.K., Tello, C., Liebmann, J.M., Ritch, R., 2007. Narrow angles and angle closure: anatomic reasons for earlier closure of the superior portion of the iridocorneal angle. Arch. Ophthalmol., 125(6):734-739.

[8]Gündüz, K., Hoşal, B.M., Zilelioğlu, G., Günalp, I., 2007. The use of ultrasound biomicroscopy in the evaluation of anterior segment tumors and simulating conditions. Ophthalmologica, 221(5):305-312.

[9]He, M., Foster, P.J., Ge, J., Huang, W., Wang, D., Friedman, D.S., Khaw, P.T., 2006. Gonioscopy in adult Chinese: the Liwan Eye Study. Invest. Ophthalmol. Vis. Sci., 47(11):4772-4779.

[10]Kuchenbecker, J., Motschmann, M., Klaus Schmitz, K., 2000. Laser iridocystotomy for bilateral acute angle-closure glaucoma secondary to iris cysts. Am. J. Ophthalmol., 129(3):391-393.

[11]Kunimatsu, S., Araie, M., Ohara, K., Behrens-Baumann, W., 1999. Ultrasound biomicroscopy of ciliary body cysts. Am. J. Ophthalmol., 127(1):48-55.

[12]Lim, M.C., Lim, L.S., Gazzard, G., Husain, R., Chan, Y.H., Seah, S.K., Aung, T., 2006. Lens opacity, thickness, and position in subjects with acute primary angle closure. J. Glaucoma, 15(3):260-263.

[13]Lois, N., Shields, C.L., Shields, J.A., Mercado, G., 1998. Primary cysts of the iris pigment epithelium. Clinical features and natural course in 234 patients. Ophthalmology, 105(10):1879-1885.

[14]Marchini, G., Pagliarusco, A., Toscano, A., Tosi, R., Brunelli, C., Bonomi, L., 1998. Ultrasound biomicroscopic and conventional ultrasonographic study of ocular dimensions in primary angle-closure glaucoma. Ophthalmology, 105(11):2091-2098.

[15]Marigo, F.A., Esaki, K., Finger, P.T., Ishikawa, H., Greenfield, D.S., Liebmann, J.M., Ritch, R., 1999. Differential diagnosis of anterior segment cysts by ultrasound biomicroscopy. Ophthalmology, 106(11):2131-2135.

[16]McWhae, J.A., Rinke, M., Crichton, A.C., 2007. Multiple bilateral iridociliary cysts: ultrasound biomicroscopy and clinical characteristics. Can. J. Ophthalmol., 42(2):268-271.

[17]Minavi, A.Z., Holdeman, N.R., 2007. Peripheral pigmentary iris cyst: evaluation and differential diagnosis. Clin. Exp. Optom., 90(1):49-52.

[18]Ritch, R., Chang, B.M., Liebmann, J.M., 2003. Angle closure in younger patients. Ophthalmology, 110(10):1880-1889.

[19]Shields, J.A., Kline, M.W., Augsburger, J.J., 1984. Primary iris cysts: a review of the literature and report of 62 cases. Br. J. Ophthalmol., 68(3):152-156.

[20]Shukla, S., Damji, K.F., Harasymowycz, P., Chialant, D., Kent, J.S., Chevrier, R., Buhrmann, R., Marshall, D., Pan, Y., Hodge, W., 2008. Clinical features distinguishing angle closure from pseudoplateau versus plateau iris. Br. J. Ophthalmol., 92(3):340-344.

[21]Stieger, R., Kniestedt, C., Sutter, F., Bachmann, L.M., Stuermer, J., 2007. Prevalence of plateau iris syndrome in young patients with recurrent angle closure. Clin. Exp. Ophthalmol., 35(5):409-413.

[22]van Herick, W., Shaffer, R.N., Schwartz, A., 1969. Estimation of width of angle of anterior chamber. Incidence and significance of the narrow angle. Am. J. Ophthalmol., 68(4):626-629.

[23]Xiao, Y., Wang, Y., Niu, G., Li, K., 2006. Transpupillary argon laser photocoagulation and Nd:YAG laser cystotomy for peripheral iris pigment epithelium cyst. Am. J. Ophthalmol., 142(4):691-693.

[24]Yan, P.S., Lin, H.T., Wang, Q.L., Zhang, Z.P., 2010. Anterior segment variations with age and accommodation demonstrated by slit-lamp-adapted optical coherence tomography. Ophthalmology, 117(12):2301-2307.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE