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CLC number: TS225.1; TS201.4

On-line Access: 2020-08-04

Received: 2020-03-08

Revision Accepted: 2020-05-11

Crosschecked: 2020-07-10

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Li-rong Shen


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.657-667


New observations on the effect of camellia oil on fatty liver disease in rats

Author(s):  Chun-xue Li, Li-rong Shen

Affiliation(s):  Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   shenlirong@zju.edu.cn

Key Words:  Camellia oil, Fatty acid, Lipid droplet, Hepatocyte ultrastructure, Organelle

Chun-xue Li, Li-rong Shen. New observations on the effect of camellia oil on fatty liver disease in rats[J]. Journal of Zhejiang University Science B, 2020, 21(8): 657-667.

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author="Chun-xue Li, Li-rong Shen",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T New observations on the effect of camellia oil on fatty liver disease in rats
%A Chun-xue Li
%A Li-rong Shen
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 8
%P 657-667
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%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000101

T1 - New observations on the effect of camellia oil on fatty liver disease in rats
A1 - Chun-xue Li
A1 - Li-rong Shen
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 8
SP - 657
EP - 667
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000101

camellia oil has become an important plant oil in China in recent years, but its effects on non-alcoholic fatty liver disease (NAFLD) have not been documented. In this study, the effects of camellia oil, soybean oil, and olive oil on NAFLD were evaluated by analyzing the fatty acid profiles of the plant oils, the serum lipids and lipoproteins of rats fed different oils, and by cytological and ultrastructural observation of the rats’ hepatocytes. Analysis of fatty acid profiles showed that the polyunsaturated fatty acid (PUFA) n-6/n-3 ratio was 33.33 in camellia oil, 12.50 in olive oil, and 7.69 in soybean oil. Analyses of serum lipids and lipoproteins of rats showed that the levels of total cholesterol and low-density lipoprotein cholesterol in a camellia oil-fed group (COFG) were lower than those in an olive oil-fed group (OOFG) and higher than those in a soybean oil-fed group (SOFG). However, only the difference in total cholesterol between the COFG and SOFG was statistically significant. Cytological observation showed that the degree of lipid droplet (LD) accumulation in the hepatocytes in the COFG was lower than that in the OOFG, but higher than that in the SOFG. Ultrastructural analysis revealed that the size and number of the LDs in the hepatocytes of rats fed each of the three types of oil were related to the degree of damage to organelles, including the positions of nuclei and the integrity of mitochondria and endoplasmic reticulum. The results revealed that the effect of camellia oil on NAFLD in rats was greater than that of soybean oil, but less than that of olive oil. Although the overall trend was that among the three oil diets, those with a lower n-6/n-3 ratio were associated with a lower risk of NAFLD, and the effect of camellia oil on NAFLD was not entirely related to the n-6/n-3 ratio and may have involved other factors. This provides new insights into the effect of oil diets on NAFLD.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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