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Yihan PENG


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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.1 P.47-62


DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy

Author(s):  Yihan PENG, Huadong PEI

Affiliation(s):  Department of Biochemistry and Molecular Medicine, the George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA; more

Corresponding email(s):   huadongpei@gwu.edu

Key Words:  Alkylation repair, Base excision repair, Methyl-guanine methyltransferase (MGMT), AlkB homolog (ALKBH)

Yihan PENG, Huadong PEI. DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy[J]. Journal of Zhejiang University Science B, 2021, 22(1): 47-62.

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author="Yihan PENG, Huadong PEI",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy
%A Yihan PENG
%A Huadong PEI
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 1
%P 47-62
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000344

T1 - DNA alkylation lesion repair: outcomes and implications in cancer chemotherapy
A1 - Yihan PENG
A1 - Huadong PEI
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 1
SP - 47
EP - 62
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000344

Alkylated DNA lesions, induced by both exogenous chemical agents and endogenous metabolites, represent a major form of DNA damage in cells. The repair of alkylation damage is critical in all cells because such damage is cytotoxic and potentially mutagenic. Alkylation chemotherapy is a major therapeutic modality for many tumors, underscoring the importance of the repair pathways in cancer cells. Several different pathways exist for alkylation repair, including base excision and nucleotide excision repair, direct reversal by methyl-guanine methyltransferase (MGMT), and dealkylation by the alkB homolog (ALKBH) protein family. However, maintaining a proper balance between these pathways is crucial for the favorable response of an organism to alkylating agents. Here, we summarize the progress in the field of DNA alkylation lesion repair and describe the implications for cancer chemotherapy.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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