Full Text:   <1891>

Summary:  <1373>

CLC number: 

On-line Access: 2021-03-12

Received: 2020-08-24

Revision Accepted: 2020-11-19

Crosschecked: 2021-02-24

Cited: 0

Clicked: 3070

Citations:  Bibtex RefMan EndNote GB/T7714




-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.3 P.190-203


Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis

Author(s):  Bingyu SUN, Yongqiang LIU, Danhua HE, Jinke LI, Jiawei WANG, Wulin WEN, Ming HONG

Affiliation(s):  Institute of Advanced Diagnostic and Clinical Medicine, Zhongshan People's Hospital, Guangzhou University & Zhongshan People's Hospital Joint Biomedical Institute, Zhongshan 528400, China; more

Corresponding email(s):   richard8207@126.com, hongming530@126.com

Key Words:  Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), Cancer therapy, Chinese medicine, Apoptosis

Bingyu SUN, Yongqiang LIU, Danhua HE, Jinke LI, Jiawei WANG, Wulin WEN, Ming HONG. Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis[J]. Journal of Zhejiang University Science B, 2021, 22(3): 190-203.

@article{title="Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis",
author="Bingyu SUN, Yongqiang LIU, Danhua HE, Jinke LI, Jiawei WANG, Wulin WEN, Ming HONG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis
%A Bingyu SUN
%A Yongqiang LIU
%A Danhua HE
%A Jinke LI
%A Jiawei WANG
%A Wulin WEN
%A Ming HONG
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 3
%P 190-203
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000497

T1 - Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis
A1 - Bingyu SUN
A1 - Yongqiang LIU
A1 - Danhua HE
A1 - Jinke LI
A1 - Jiawei WANG
A1 - Wulin WEN
A1 - Ming HONG
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 3
SP - 190
EP - 203
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000497

The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments. Most current chemotherapy agents have significant cytotoxicity, which leads to devastating adverse effects and results in a substandard quality of life, including increased daily morbidity and premature mortality. The death receptor of apoptosis-inducing ligand (TRAIL)%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells. However, various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways. Therefore, it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL, and to reinforce TRAIL's ability to induce tumor cell apoptosis. In recent years, traditional chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines. This review aims to collate information about chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL's ability to induce apoptosis. We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anti-cancer drugs for human cancer treatment. This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed. “TRAIL sensitize” and “chinese medicine” were the search keywords. We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis. The name of each plant was validated using certified databases such as The Plant List. This study indicates that TRAIL can be combined with different chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis. It also demonstrates that the active ingredients of traditional chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis. This provides useful information regarding traditional chinese medicine treatment, the development of TRAIL-based therapies, and the treatment of cancer.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]AggarwalBB, KumarA, BhartiAC, 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res, 23(1A):363-398.

[2]AlmasanA, AshkenaziA, 2003. Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev, 14(3-4):337-348.

[3]AntonoffMB, ChughR, Borja-CachoD, et al., 2009. Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo. Surgery, 146(2):282-290.

[4]BrincksEL, KucabaTA, JamesBR, et al., 2015. Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma. FEBS J, 282(24):4747-4765.

[5]CaiXT, YeTM, LiuC, et al., 2011. Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells. Toxicol in Vitro, 25(7):1385-1391.

[6]ChaeS, KangKA, ChangWY, et al., 2009. Effect of compound K, a metabolite of ginseng saponin, combined with γ-ray radiation in human lung cancer cells in vitro and in vivo. J Agric Food Chem, 57(13):5777-5782.

[7]ChenJ, WangFL, ChenWD, 2014. Modulation of apoptosis-related cell signalling pathways by curcumin as a strategy to inhibit tumor progression. Mol Biol Rep, 41(7):‍4583-4594.

[8]ChenL, MengY, SunQ, et al., 2016. Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation. Cell Death Dis, 7(8):e2334.

[9]ChenZ, JinK, GaoLY, et al., 2010. Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol, 643(2-‍3):170-179.

[10]ChenZY, SangwanV, BanerjeeS, et al., 2014. Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the Death Receptor pathway. Cancer Lett, 348(1-2):156-166.

[11]ChengL, ShiL, WuJ, et al., 2018. A hederagenin saponin isolated from Clematis ganpiniana induces apoptosis in breast cancer cells via the mitochondrial pathway. Oncol Lett, 15(2):1737-1743.

[12]ChoHD, LeeJH, MoonKD, et al., 2018. Auriculasin-induced ROS causes prostate cancer cell death via induction of apoptosis. Food Chem Toxicol, 111:660-669.

[13]ChoHD, GuIA, WonYS, et al., 2019. Auriculasin sensitizes primary prostate cancer cells to TRAIL-mediated apoptosis through up-regulation of the DR5-dependent pathway. Food Chem Toxicol, 126:223-232.

[14]ChuangTC, HsuSC, ChengYT, et al., 2011. Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells. Cancer Lett, 311(1):11-19.

[15]ClawsonKA, Borja-CachoD, AntonoffMB, et al., 2010. Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma. J Surg Res, 163(2):244-249.

[16]DanielsRA, TurleyH, KimberleyFC, et al., 2005. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res, 15(6):430-438.

[17]de MiguelD, LemkeJ, AnelA, et al., 2016. Onto better TRAILs for cancer treatment. Cell Death Differ, 23(5):733-747.

[18]DeebD, JiangH, GaoXH, et al., 2004. Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L by inhibiting nuclear factor-κB through suppression of IκBα phosphorylation. Mol Cancer Ther, 3(7):803-812.

[19]DeebD, JiangH, GaoXH, et al., 2007. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)‍-1‍-‍6-heptadine-3,‍5-dione;C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-κB via inhibition of the prosurvival Akt signaling pathway. J Pharmacol Exp Ther, 321(2):616-625.

[20]DelbridgeARD, StrasserA, 2015. The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell Death Differ, 22(7): 1071-1080.

[21]DengYY, BiR, GuoHR, et al., 2019. Andrographolide enhances TRAIL-induced apoptosis via p53-mediated death receptors up-regulation and suppression of the NF-κB pathway in bladder cancer cells. Int J Biol Sci, 15(3):688-700.

[22]DevassyJG, NwachukwuID, JonesPJH, 2015. Curcumin and cancer: barriers to obtaining a health claim. Nutr Rev, 73(3):155-165.

[23]DudejaV, MujumdarN, PhillipsP, et al., 2009. Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology, 136(5):1772-1782.

[24]EomKS, HongJM, YounMJ, et al., 2008. Berberine induces G1 arrest and apoptosis in human glioblastoma T98G cells through mitochondrial/caspases pathway. Biol Pharm Bull, 31(4):558-562.

[25]FalschlehnerC, EmmerichCH, GerlachB, et al., 2007. TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol, 39(7-8):1462-1475.

[26]Goncharenko-KhaiderN, LaneD, MatteI, et al., 2010. The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells. Oncogene, 29(40):5523-5536.

[27]GongK, LiWH, 2011. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: a potential new treatment for hepatocellular carcinoma. Free Radic Biol Med, 51(12):2259-2271.

[28]GonzalvezF, AshkenaziA, 2010. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene, 29(34):4752-4765.

[29]GorriniC, HarrisIS, MakTW, 2013. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov, 12(12):931-947.

[30]Guamán OrtizLM, TillhonM, ParksM, et al., 2014. Multiple effects of berberine derivatives on colon cancer cells. Biomed Res Int, 2014:924585.

[31]GuesmiF, HmedMB, PrasadS, et al., 2019. In vivo pathogenesis of colon carcinoma and its suppression by hydrophilic fractions of Clematis flammula via activation of TRAIL death machinery (DRs) expression. Biomed Pharmacother, 109:2182-2191.

[32]GuoZL, LiJZ, MaYY, et al., 2018. Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathways. BMC Cell Biol, 19:29.

[33]GuptaSC, FrancisSK, NairMS, et al., 2013. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem, 288(45):32343-32356.

[34]HartwigT, MontinaroA, von KarstedtS, et al., 2017. The TRAIL-induced cancer secretome promotes a tumor-supportive immune microenvironment via CCR2. Mol Cell, 65(4):730-742.e5.

[35]HasegawaH, SungJH, HuhJH, 1997. Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent. Arch Pharm Res, 20(6):539-544.

[36]HayakawaY, ScrepantiV, YagitaH, et al., 2004. NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy. J Immunol, 172(1): 123-129.

[37]HeGD, HeGL, ZhouRY, et al., 2016. Enhancement of cisplatin-induced colon cancer cells apoptosis by shikonin, a natural inducer of ROS in vitro and in vivo. Biochem Biophys Res Commun, 469(4):1075-1082.

[38]HempelJ, PforteH, RaabB, et al., 1999. Flavonols and flavones of parsley cell suspension culture change the antioxidative capacity of plasma in rats. Nahrung, 43(3):201-204.

[39]HollandPM, 2013. Targeting Apo2L/TRAIL receptors by soluble Apo2L/TRAIL. Cancer Lett, 332(2):156-162.

[40]HongM, LiJK, LiSY, et al., 2019. Acetylshikonin sensitizes hepatocellular carcinoma cells to apoptosis through ROS-mediated caspase activation. Cells, 8(11):1466.

[41]HuXW, SunY, 2012. Triptolide sensitizes TRAIL-induced apoptosis in prostate cancer cells via p53-mediated DR5 up-regulation. Mol Biol Rep, 39(9):8763-8770.

[42]HuangSB, SinicropeFA, 2008. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res, 68(8):2944-2951.

[43]HuangSY, 2007. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res, 13(5):1362-1366.

[44]HuangWR, ZhangY, TangX, 2014. Shikonin inhibits the proliferation of human lens epithelial cells by inducing apoptosis through ROS and caspase-dependent pathway. Molecules, 19(6):7785-7797.

[45]JohnstoneRW, FrewAJ, SmythMJ, 2008. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer, 8(10):782-798.

[46]JungSH, LeeYS, LeeS, et al., 2002. Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. Arch Pharm Res, 25(3):306-312.

[47]KalkavanH, GreenDR, 2018. MOMP, cell suicide as a BCL-2 family business. Cell Death Differ, 25(1):46-55.

[48]KeR, VishnoiK, ViswakarmaN, et al., 2018. Involvement of AMP-activated protein kinase and death receptor 5 in TRAIL-berberine-induced apoptosis of cancer cells. Sci Rep, 8(1):5521.

[49]KimAD, KangKA, KimHS, et al., 2013. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis, 4(8):e750.

[50]KisimA, AtmacaH, CakarB, et al., 2012. Pretreatment with AT-101 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)‍-induced apoptosis of breast cancer cells by inducing death receptors 4 and 5 protein levels. J Cancer Res Clin Oncol, 138(7):1155-1163.

[51]KretzAL, von KarstedtS, HillenbrandA, et al., 2018. Should we keep walking along the trail for pancreatic cancer treatment? Revisiting TNF-related apoptosis-inducing ligand for anticancer therapy. Cancers, 10(3):77.

[52]KroschTCK, SangwanV, BanerjeeS, et al., 2013. Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity. Am J Surg, 205(4): 387-396.

[53]KwilasAR, ArdianiA, GameiroSR, et al., 2016. Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin. Oncotarget, 7(17):23498-23511.

[54]LeeDH, SungKS, BartlettDL, et al., 2015. HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells. Cell Signal, 27(2):293-305.

[55]LeeSJ, NohHJ, SungEG, et al., 2011. Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins. Int J Oncol, 38(2):485-492.

[56]LemkeJ, von KarstedtS, ZinngrebeJ, et al., 2014. Getting TRAIL back on track for cancer therapy. Cell Death Differ, 21(9):1350-1364.

[57]LiHL, ZhuH, XuCJ, et al., 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94(4):491-501.

[58]LiWJ, LiuJ, JacksonK, et al., 2014. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS ONE, 9(4):e94079.

[59]LimSH, HaTY, KimSR, et al., 2009. Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats. Br J Nutr, 101(7):1031-1039.

[60]LinY, ShiRX, WangX, et al., 2008. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets, 8(7):634-646.

[61]LiuT, LiuX, LiWH, 2016. Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy. Oncotarget, 7(26):40800-40815.

[62]LiuYT, TongYL, YangX, et al., 2016. Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer. Pharmacol Res, 111:113-125.

[63]MittraB, SahaA, ChowdhuryAR, et al., 2000. Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis. Mol Med, 6(6):527-541.

[64]MorrisseyC, BekticJ, SpenglerB, et al., 2004. Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro. J Urol, 172(6 Pt 1):2426-2433.

[65]MujumdarN, MackenzieTN, DudejaV, et al., 2010. Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology, 139(2):598-608.

[66]MurthyKNC, JayaprakashaGK, PatilBS, 2012. The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells. Eur J Pharmacol, 688(1-3):14-21.

[67]NazimUM, ParkSY, 2019. Luteolin sensitizes human liver cancer cells to TRAIL-induced apoptosis via autophagy and JNK-mediated death receptor 5 upregulation. Int J Oncol, 54(2):665-672.

[68]OuYC, KuanYH, LiJR, et al., 2013. Induction of apoptosis by luteolin involving Akt inactivation in human 786-O renal cell carcinoma cells. Evid Based Complement Alternat Med, 2013:109105.

[69]PanGH, NiJ, WeiYF, et al., 1997. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science, 277(5327):815-818.

[70]PanLL, WangXL, ZhangQY, et al., 2016. Boehmenan, a lignan from the Chinese medicinal plant Clematis armandii, induces apoptosis in lung cancer cells through modulation of EGF-dependent pathways. Phytomedicine, 23(5):468-476.

[71]ParkEJ, ZhaoYZ, KimYC, et al., 2005. Protective effect of (S)‍-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo. Planta Med, 71(6):508-513.

[72]ParkMH, KimJH, ChungYH, et al., 2016. Bakuchiol sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins. Biochem Biophys Res Commun, 473(2):586-592.

[73]ParkS, ChoDH, AnderaL, et al., 2013. Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins. Mol Cell Biochem, 383(1-2):39-48.

[74]RefaatA, AbdelhamedS, YagitaH, et al., 2013. Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer. Oncol Lett, 6(3):840-844.

[75]RefaatA, AbdelhamedS, SaikiI, et al., 2015. Inhibition of p38 mitogen-activated protein kinase potentiates the apoptotic effect of berberine/tumor necrosis factor-related apoptosis-inducing ligand combination therapy. Oncol Lett, 10(3):1907-1911.

[76]SeerviM, RaniA, SharmaAK, et al., 2018. ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine. Biomed Pharmacother, 106:200-209.

[77]ShishodiaG, KoulS, DongQ, et al., 2018. Tetrandrine (TET) induces death receptors Apo TRAIL R1 (DR4) and Apo TRAIL R2 (DR5) and sensitizes prostate cancer cells to TRAIL-induced apoptosis. Mol Cancer Ther, 17(6):1217-1228.

[78]SinghS, SinghPP, RobertsLR, et al., 2014. Chemopreventive strategies in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol, 11(1):45-54.

[79]TrauzoldA, WermannH, ArltA, et al., 2001. CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-κB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells. Oncogene, 20(31):4258-4269.

[80]TrivediR, MishraDP, 2015. Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells. Front Oncol, 5:69.

[81]WangFF, YaoXS, ZhangYW, et al., 2019. Synthesis, biological function and evaluation of shikonin in cancer therapy. Fitoterapia, 134:329-339.

[82]WangG, LemosJR, IadecolaC, 2004. Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci, 25(3):120-123.

[83]WangSL, El-DeiryWS, 2003. TRAIL and apoptosis induction by TNF-family death receptors. Oncogene, 22(53):8628-8633.

[84]WangY, Curtis-LongMJ, YukHJ, et al., 2013. Bacterial neuraminidase inhibitory effects of prenylated isoflavones from roots of Flemingia philippinensis. Bioorg Med Chem, 21(21):6398-6404.

[85]WangZX, QiFH, CuiYG, et al., 2018. An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics. BioSci Trends, 12(3):220-239.

[86]WeiN, LiuGT, ChenXG, et al., 2011. H1, a derivative of Tetrandrine, exerts anti-MDR activity by initiating intrinsic apoptosis pathway and inhibiting the activation of Erk1/2 and Akt1/2. Biochem Pharmacol, 82(11):1593-1603.

[87]WeiRJ, ZhangXS, HeDL, 2018. Andrographolide sensitizes prostate cancer cells to TRAIL-induced apoptosis. Asian J Androl, 20(2):200-204.

[88]WooSM, SeoSU, KubatkaP, et al., 2019. Honokiol enhances TRAIL-mediated apoptosis through STAMBPL1-induced survivin and c-FLIP degradation. Biomolecules, 9(12):838.

[89]WozniakD, JandaB, KapustaI, et al., 2010. Antimutagenic and anti-oxidant activities of isoflavonoids from Belamcanda chinensis (L.) DC. Mutat Res/Genet Toxicol Environ Mutagen, 696(2):148-153.

[90]XiaYF, YeBQ, LiYD, et al., 2004. Andrographolide attenuates inflammation by inhibition of NF-‍κB activation through covalent modification of reduced cysteine 62 of p50. J Immunol, 173(6):4207-4217.

[91]XuY, LiPZ, ZhangX, et al., 2014. In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci, 14(3):564-569.

[92]XuY, GaoCC, PanZG, et al., 2018. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Biochem Biophys Res Commun, 496(3):998-1005.

[93]YamaguchiR, LartigueL, PerkinsG, 2019. Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy. Pharmacol Ther, 195:13-20.

[94]YangX, LiZJ, WuQJ, et al., 2017. TRAIL and curcumin codelivery nanoparticles enhance TRAIL-induced apoptosis through upregulation of death receptors. Drug Deliv, 24(1):1526-1536.

[95]YoudimKA, QaiserMZ, BegleyDJ, et al., 2004. Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med, 36(5):592-604.

[96]ZangMD, HuL, FanZY, et al., 2017. Luteolin suppresses gastric cancer progression by reversing epithelial-mesenchymal transition via suppression of the Notch signaling pathway. J Transl Med, 15:52.

[97]ZhangL, WeiKH, XuJP, et al., 2016. Belamcanda chinensis (L.) DC—an ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol, 186:1-13.

[98]ZhangLD, FangBL, 2005. Mechanisms of resistance to TRAIL-induced apoptosis in cancer. Cancer Gene Ther, 12(3):228-237.

[99]ZhouGY, YangZQ, WangXD, et al., 2017. TRAIL enhances shikonin induced apoptosis through ROS/JNK signaling in cholangiocarcinoma cells. Cell Physiol Biochem, 42(3):1073-1086.

[100]ZhouJ, LuGD, OngCS, et al., 2008. Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation. Mol Cancer Ther, 7(7):2170-2180.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE