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Chaochao YU


Yingwen ZHANG


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.7 P.547-563


Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges

Author(s):  Chaochao YU, Yi LI, Guopeng CHEN, Chaoyan WU, Xiuping WANG, Yingwen ZHANG

Affiliation(s):  Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China; more

Corresponding email(s):   hhao3838@sina.com

Key Words:  Breast cancer, Traditional Chinese medicinal material (TCMM), Bioactive constituent, Anticancer effect

Chaochao YU, Yi LI, Guopeng CHEN, Chaoyan WU, Xiuping WANG, Yingwen ZHANG. Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges[J]. Journal of Zhejiang University Science B, 2022, 23(7): 547-563.

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author="Chaochao YU, Yi LI, Guopeng CHEN, Chaoyan WU, Xiuping WANG, Yingwen ZHANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges
%A Chaochao YU
%A Yi LI
%A Guopeng CHEN
%A Chaoyan WU
%A Xiuping WANG
%A Yingwen ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 7
%P 547-563
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2101019

T1 - Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges
A1 - Chaochao YU
A1 - Yi LI
A1 - Guopeng CHEN
A1 - Chaoyan WU
A1 - Xiuping WANG
A1 - Yingwen ZHANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 7
SP - 547
EP - 563
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2101019

breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery, radiotherapy, chemotherapy, immunotherapy, and endocrine therapy are currently the main treatments for this cancer type. However, some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy, resulting in limited treatment efficacy. Consequently, traditional Chinese medicinal materials (TCMMs) as natural products have become an attractive source of novel drugs. In this review, we summarized the current knowledge on the active components of animal-derived TCMMs, including Ophiocordyceps sinensis-derived cordycepin, the aqueous and ethanolic extracts of O. sinensis, norcantharidin (NCTD), Chansu, bee venom, deer antlers, Ostrea gigas, and scorpion venom, with reference to marked anti-breast cancer effects due to regulating cell cycle arrest, proliferation, apoptosis, metastasis, and drug resistance. In future studies, the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies. Furthermore, large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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