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On-line Access: 2022-08-12

Received: 2022-01-17

Revision Accepted: 2022-05-11

Crosschecked: 2022-08-12

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jinghong XU

https://orcid.org/0000-0001-5602-4480

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.8 P.699-704

http://doi.org/10.1631/jzus.B2200036


Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study


Author(s):  Zeren SHEN, Jinjin SHAO, Jiaqi SUN, Jinghong XU

Affiliation(s):  Department of Plastic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   doctorxjh@zju.edu.cn

Key Words:  Exosome, melanocyte, fibroblast, keloid, miRNAs


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Zeren SHEN, Jinjin SHAO, Jiaqi SUN, Jinghong XU. Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study[J]. Journal of Zhejiang University Science B, 2022, 23(8): 699-704.

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publisher="Zhejiang University Press & Springer",
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Abstract: 
keloids are a common type of pathological scar as a result of skin healing, which are extremely difficult to prevent and treat without recurrence. The pathological mechanism of keloids is the excessive proliferation of fibroblasts, which synthesize more extracellular matrices (ECMs), including type I/III collagen (COL-1/3), mucopolysaccharides, connective tissue growth factor (CTGF, also known as cellular communication network factor 2 (CCN2)), and fibronectin (FN) in scar tissue, mostly through the abnormal activation of transforming growth factor-?? (TGF-??)/Smads pathway (Finnson et al., 2013; Song et al., 2018). Genetic factors, including race and skin tone, are considered to contribute to keloid formation. The reported incidence of keloids in black people is as high as 16%, whereas white people are less affected. The prevalence ratio of colored people to white people is 5:1????15:1 (Rockwell et al., 1989; LaRanger et al., 2019). In addition, keloids have not been reported in albinism patients of any race, and those with darker skin in the same race are more likely to develop this disease (LaRanger et al., 2019). Skin melanocyte activity is significantly different among people with different skin tones. The more active the melanocyte function, the more melanin is produced and the darker the skin. Similarly, in the same individual, the incidence of keloids increases during periods when melanocytes are active, such as adolescence and pregnancy. keloids rarely appear in areas where melanocytes synthesize less melanin, such as in the palms and soles. Thus, the formation of keloids seems to be closely related to melanocyte activity.

黑色素细胞通过释放外泌体调控成纤维细胞以促进瘢痕疙瘩形成的初步研究

沈泽仁1,邵金金2,孙佳琦1,徐靖宏1
1浙江大学医学院附属第一医院整形外科,中国杭州市,310003
2杭州医学院安全性评价研究中心,中国杭州市,310059
概要:瘢痕疙瘩是常见病理性皮肤愈合,极难预防和根治。临床发现黑色素细胞活性较高的深肤色人群具有瘢痕疙瘩易感性,提示黑色素细胞可能参与其形成过程。瘢痕疙瘩主要由成纤维细胞中TGF-β/Smads通路异常激活所致,而文献报道黑色素细胞分泌物能激活成纤维细胞中TGF-β信号,但机制不明。我们前期研究发现携带特定miRNAs的黑色素细胞外泌体可激活成纤维细胞内TGF-β/Smads通路,从而促进瘢痕疙瘩形成。本研究将从细胞间对话角度揭示深肤色人群易感瘢痕疙瘩的内在机理。

关键词:外泌体;黑色素细胞;成纤维细胞;瘢痕疙瘩;miRNAs

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