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On-line Access: 2022-08-12

Received: 2022-01-17

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Crosschecked: 2022-08-12

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Jinghong XU


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.8 P.699-704


Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study

Author(s):  Zeren SHEN, Jinjin SHAO, Jiaqi SUN, Jinghong XU

Affiliation(s):  Department of Plastic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   doctorxjh@zju.edu.cn

Key Words:  Exosome, melanocyte, fibroblast, keloid, miRNAs

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Zeren SHEN, Jinjin SHAO, Jiaqi SUN, Jinghong XU. Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study[J]. Journal of Zhejiang University Science B, 2022, 23(8): 699-704.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study
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%A Jiaqi SUN
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%J Journal of Zhejiang University SCIENCE B
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%DOI 10.1631/jzus.B2200036

T1 - Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study
A1 - Zeren SHEN
A1 - Jinjin SHAO
A1 - Jiaqi SUN
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DOI - 10.1631/jzus.B2200036

keloids are a common type of pathological scar as a result of skin healing, which are extremely difficult to prevent and treat without recurrence. The pathological mechanism of keloids is the excessive proliferation of fibroblasts, which synthesize more extracellular matrices (ECMs), including type I/III collagen (COL-1/3), mucopolysaccharides, connective tissue growth factor (CTGF, also known as cellular communication network factor 2 (CCN2)), and fibronectin (FN) in scar tissue, mostly through the abnormal activation of transforming growth factor-?? (TGF-??)/Smads pathway (Finnson et al., 2013; Song et al., 2018). Genetic factors, including race and skin tone, are considered to contribute to keloid formation. The reported incidence of keloids in black people is as high as 16%, whereas white people are less affected. The prevalence ratio of colored people to white people is 5:1????15:1 (Rockwell et al., 1989; LaRanger et al., 2019). In addition, keloids have not been reported in albinism patients of any race, and those with darker skin in the same race are more likely to develop this disease (LaRanger et al., 2019). Skin melanocyte activity is significantly different among people with different skin tones. The more active the melanocyte function, the more melanin is produced and the darker the skin. Similarly, in the same individual, the incidence of keloids increases during periods when melanocytes are active, such as adolescence and pregnancy. keloids rarely appear in areas where melanocytes synthesize less melanin, such as in the palms and soles. Thus, the formation of keloids seems to be closely related to melanocyte activity.




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