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Received: 2010-09-20

Revision Accepted: 2011-01-20

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.6 P.485-491


A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest

Author(s):  Qi Wang, Jing Qin, Lu-yue Gai, Yun-dai Chen, Wei Dong, Zhi-wei Guan, Zhi-guo Wang, Zhi-jun Sun, Jia-he Tian

Affiliation(s):  Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China, Department of Ultrasound, Chinese Armed Police General Hospital, Beijing 100039, China, Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing 100853, China

Corresponding email(s):   luyuegai301@yahoo.com.cn

Key Words:  Coronary artery disease, Myocardial ischemia, Perfusion, Multislice computed tomography

Qi Wang, Jing Qin, Lu-yue Gai, Yun-dai Chen, Wei Dong, Zhi-wei Guan, Zhi-guo Wang, Zhi-jun Sun, Jia-he Tian. A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest[J]. Journal of Zhejiang University Science B, 2011, 12(6): 485-491.

@article{title="A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest",
author="Qi Wang, Jing Qin, Lu-yue Gai, Yun-dai Chen, Wei Dong, Zhi-wei Guan, Zhi-guo Wang, Zhi-jun Sun, Jia-he Tian",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest
%A Qi Wang
%A Jing Qin
%A Lu-yue Gai
%A Yun-dai Chen
%A Wei Dong
%A Zhi-wei Guan
%A Zhi-guo Wang
%A Zhi-jun Sun
%A Jia-he Tian
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 6
%P 485-491
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000342

T1 - A pilot study on diagnosis of coronary artery disease using computed tomography first-pass myocardial perfusion imaging at rest
A1 - Qi Wang
A1 - Jing Qin
A1 - Lu-yue Gai
A1 - Yun-dai Chen
A1 - Wei Dong
A1 - Zhi-wei Guan
A1 - Zhi-guo Wang
A1 - Zhi-jun Sun
A1 - Jia-he Tian
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 6
SP - 485
EP - 491
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000342

Background: Although computed tomography coronary angiography (CTCA) can identify coronary stenosis, little data exists on the ability of multislice computed tomography (MSCT) to detect myocardial perfusion defects at rest. Methods: In 33 patients with diagnosed or suspected coronary artery disease (CAD), CTCA using retrospective electrocardiography (ECG) gating at rest and invasive coronary angiography (ICA) was performed. The 2D myocardial images were reconstructed in diastolic and systolic phases using the same raw data for CTCA. CT values of the myocardium were used as an estimate of myocardial enhancement, which were shown by color mapping. myocardial ischemia was defined as a pattern of transient endocardial hypo-enhancement at systole and normal enhancement at diastole. The results of ICA were taken as the reference standard. Results: When a diameter reduction of more than 50% in ICA was used as diagnostic criteria of CAD, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CT first-pass myocardial perfusion imaging (MPI) at rest were 0.85, 0.67, 0.92, and 0.50 per patient, respectively, and 0.58, 0.93, 0.85, and 0.76 per vessel, respectively. Conclusions: CT first-pass MPI at rest could detect CAD patients, which could become a practical and convenient way to detect ischemia, consequently offering the ability for MSCT to act as a “one stop shop” for the diagnosis of CAD.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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