Full Text:   <42>

CLC number: 

On-line Access: 2022-08-22

Received: 2022-05-10

Revision Accepted: 2022-07-28

Crosschecked: 0000-00-00

Cited: 0

Clicked: 114

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200269


Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma


Author(s):  Lin ZHANG, Yuanyuan CAO, Xiaoxiao GUO, Xiaoyu WANG, Xiao HAN, Kouminin Kanwore, Xiaoliang HONG, Han ZHOU, Dianshuai GAO

Affiliation(s):  School of Nursing, Xuzhou Medical University, Xuzhou 221004, China; more

Corresponding email(s):   gds@xzhmu.edu.cn

Key Words:  Glioblastoma, Hypoxia, ROS, HIF-1α


Lin ZHANG, Yuanyuan CAO, Xiaoxiao GUO, Xiaoyu WANG, Xiao HAN, Kouminin Kanwore, Xiaoliang HONG, Han ZHOU, Dianshuai GAO. Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

@article{title="Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma",
author="Lin ZHANG, Yuanyuan CAO, Xiaoxiao GUO, Xiaoyu WANG, Xiao HAN, Kouminin Kanwore, Xiaoliang HONG, Han ZHOU, Dianshuai GAO",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200269"
}

%0 Journal Article
%T Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma
%A Lin ZHANG
%A Yuanyuan CAO
%A Xiaoxiao GUO
%A Xiaoyu WANG
%A Xiao HAN
%A Kouminin Kanwore
%A Xiaoliang HONG
%A Han ZHOU
%A Dianshuai GAO
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200269

TY - JOUR
T1 - Hypoxia-induced ROS aggravate tumor progression through HIF-1α-SERPINE1 signaling in glioblastoma
A1 - Lin ZHANG
A1 - Yuanyuan CAO
A1 - Xiaoxiao GUO
A1 - Xiaoyu WANG
A1 - Xiao HAN
A1 - Kouminin Kanwore
A1 - Xiaoliang HONG
A1 - Han ZHOU
A1 - Dianshuai GAO
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200269


Abstract: 
hypoxia, as an important hallmark of the tumor microenvironment, is a major cause of oxidative stress and plays a central role in various malignant tumors, including glioblastoma. Elevated reactive oxygen species (ROS) in a hypoxic microenvironment promote glioblastoma progression, however, the underlying mechanism has not been clarified. Herein, we found that hypoxia promoted ROS production, and the proliferation, migration and invasion of glioblastoma cells, while this promotion was restrained by ROS scavengers NAC and DPI. hypoxia-induced ROS activated hypoxia-inducible factor-1 alpha (HIF-1α;) signaling, which enhanced cell migration and invasion by epithelial-mesenchymal transition (EMT). Furthermore, the induction of serine protease inhibitor family E member 1 (SERPINE1) was ROS dependent under hypoxia, and HIF-1α; mediated SERPINE1 increase induced by ROS via binding to the SERPINE1 promoter region, thereby facilitating glioblastoma migration and invasion. Taken together, our data revealed that hypoxia-induced ROS reinforce the hypoxic adaptation of glioblastoma by driving the HIF-1α;-SERPINE1 signaling pathway, and that targeting ROS may be a promising therapeutic strategy for glioblastoma.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE