CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-01-16
Cited: 0
Clicked: 1753
Qiong ZHAO, Luwen ZHANG, Qiufen HE, Hui CHANG, Zhiqiang WANG, Hongcui CAO, Ying ZHOU, Ruolang PAN, Ye CHEN. Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways[J]. Journal of Zhejiang University Science B, 2023, 24(1): 50-63.
@article{title="Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways",
author="Qiong ZHAO, Luwen ZHANG, Qiufen HE, Hui CHANG, Zhiqiang WANG, Hongcui CAO, Ying ZHOU, Ruolang PAN, Ye CHEN",
journal="Journal of Zhejiang University Science B",
volume="24",
number="1",
pages="50-63",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200224"
}
%0 Journal Article
%T Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways
%A Qiong ZHAO
%A Luwen ZHANG
%A Qiufen HE
%A Hui CHANG
%A Zhiqiang WANG
%A Hongcui CAO
%A Ying ZHOU
%A Ruolang PAN
%A Ye CHEN
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 1
%P 50-63
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200224
TY - JOUR
T1 - Targeting TRMT5 suppresses hepatocellular carcinoma progression via inhibiting the HIF-1α pathways
A1 - Qiong ZHAO
A1 - Luwen ZHANG
A1 - Qiufen HE
A1 - Hui CHANG
A1 - Zhiqiang WANG
A1 - Hongcui CAO
A1 - Ying ZHOU
A1 - Ruolang PAN
A1 - Ye CHEN
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 1
SP - 50
EP - 63
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200224
Abstract: Accumulating evidence has confirmed the links between )%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>transfer RNA (tRNA) modifications and tumor progression. The present study is the first to explore the role of )%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>tRNA methyltransferase 5 (TRMT5), which catalyzes the m1G37 modification of mitochondrial tRNAs in )%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>hepatocellular carcinoma (HCC) progression. Here, based on bioinformatics and clinical analyses, we identified that TRMT5 expression was upregulated in HCC, which correlated with poor prognosis. Silencing TRMT5 attenuated HCC proliferation and metastasis both in vivo and in vitro, which may be partially explained by declined extracellular acidification rate (ECAR) and oxygen consumption rate (OCR). Mechanistically, we discovered that knockdown of TRMT5 inactivated the hypoxia-inducible factor-1 (HIF-1) signaling pathway by preventing HIF-1α stability through the enhancement of cellular oxygen content. Moreover, our data indicated that inhibition of TRMT5 sensitized HCC to doxorubicin by adjusting HIF-1α. In conclusion, our study revealed that targeting TRMT5 could inhibit HCC progression and increase the susceptibility of tumor cells to chemotherapy drugs. Thus, TRMT5 might be a carcinogenesis candidate gene that could serve as a potential target for HCC therapy.
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