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On-line Access: 2022-11-15

Received: 2022-05-30

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Jingsong HE

https://orcid.org/0000-0002-1190-1037

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.11 P.968-974

http://doi.org/10.1631/jzus.B2200277


High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma


Author(s):  Xiaoyan YUE, Linlin HUANG, Yang YANG, Yi ZHAO, Donghua HE, Xiaoyan HAN, Gaofeng ZHENG, Yi LI, Enfan ZHANG, Zhen CAI, Xin HUANG, Jingsong HE

Affiliation(s):  Bone Marrow Transplantation Center, Department of Hematology, the First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou310003,China; more

Corresponding email(s):   hejingsong@zju.edu.cn

Key Words:  Multiple myeloma, Interleukin-10, Extramedullary multiple myeloma, PFS, OS


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Xiaoyan YUE, Linlin HUANG, Yang YANG, Yi ZHAO, Donghua HE, Xiaoyan HAN, Gaofeng ZHENG, Yi LI, Enfan ZHANG, Zhen CAI, Xin HUANG, Jingsong HE. High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma[J]. Journal of Zhejiang University Science B, 2022, 23(11): 968-974.

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author="Xiaoyan YUE, Linlin HUANG, Yang YANG, Yi ZHAO, Donghua HE, Xiaoyan HAN, Gaofeng ZHENG, Yi LI, Enfan ZHANG, Zhen CAI, Xin HUANG, Jingsong HE",
journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200277"
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A1 - Yi LI
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Abstract: 
multiple myeloma (MM) is a common malignant hematological tumor in adults, which is characterized by clonal malignant proliferation of plasma cells in the bone marrow and secretion of a large number of abnormal monoclonal immunoglobulins (M protein), leading to bone destruction, hypercalcemia, anemia, and renal insufficiency (Alexandrakis et al., 2015; Yang et al., 2018). Since a large number of new drugs, represented by proteasome inhibitors and immunomodulators, have been successfully used to treat MM, treatment efficacy and survival of patients have been significantly improved. However, due to the high heterogeneity of this disease, patients have responded differently to treatments with these new drugs (Palumbo and Anderson, 2011; Wang et al., 2016; Huang et al., 2020). Growth and survival of MM cells depend on the bone marrow microenvironment, especially numerous inflammatory cytokines secreted by myeloma cells and bone marrow stromal cells, such as vascular endothelial growth factor (VEGF), interleukin (IL)‍-6, transforming growth factor-‍β (TGF‍‍-‍‍β), and IL-10. These cytokines can promote the growth of myeloma cells, induce angiogenesis, and inhibit antitumor immunity, and are often linked to patient prognOSis (Kumar et al., 2017). In this era of new drugs, the prognOStic values of the serum levels of these cytokines in MM need further evaluation.

血清高水平白细胞介素-10提示多发性骨髓瘤患者疾病进展、髓外累及和不良预后

岳小艳1,黄琳琳1,杨杨1,赵毅1,何冬花1,韩晓雁1,郑高锋1,李奕1,张恩帆1,蔡真1,2,3,黄昕4,何静松1
1浙江大学医学院附属第一医院血液科&骨髓移植中心,中国杭州,310003
2浙江大学血液学研究所,中国杭州,310058
3浙江大学医学中心,浙江省系统&精准医学实验室,中国杭州,311121
4浙江大学医学院附属第一医院血液科&血液学研究所,中国杭州,310003
概要:多发性骨髓瘤(MM)细胞的生长和存活依赖于骨髓微环境,其中细胞因子常与疾病的不良预后有关。在新药治疗时代,血清细胞因子水平对MM预后作用需进一步评估。本研究分析了157例初诊MM患者外周血细胞因子水平(包括白细胞介素-2(IL-2)、IL-4、IL-6、IL-10、干扰素γ(IFN-γ)、肿瘤坏死因子α(TNF-α)和IL-17A)与患者基线临床特征、疗效以及预后之间的关系。并选用15例年龄契合的健康志愿者和96例复发MM患者作为对照。所有患者均一线接受硼替佐米为基础方案的治疗。生存分析表明,上述细胞因子中,仅血清IL-10与患者的无进展生存期(PFS)和总生存期(OS)显著相关。初诊MM患者中,有103例(65.6%)患者被归为高IL-10(≥1.42 pg/mL)组,该组患者通常具有高危基因异常和临床分期,也更容易出现贫血、血小板减少,以及血清乳酸脱氢酶、C-反应蛋白和肌酐水平增高的症状。单因素分析表明高IL-10组患者有更差的PFS(P=0.040)和OS(P<0.001),多因素分析提示血清IL-10是初诊MM患者OS的独立预后因素。研究结果提示,血清IL-10水平与MM患者疾病进展和高危临床特征相关,可作为以硼替佐米为基础治疗方案的初诊MM患者OS的预后因素。

关键词:多发性骨髓瘤;白细胞介素-10;临床特征;无进展生存期;总生存期

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