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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Zhihang HU, Modan YANG, Hao CHEN, Chiyu HE, Zuyuan LIN, Xinyu YANG, Huigang LI, Wei SHEN, Di LU, Xiao XU. Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology[J]. Journal of Zhejiang University Science B, 2023, 24(5): 387-396.
@article{title="Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology",
author="Zhihang HU, Modan YANG, Hao CHEN, Chiyu HE, Zuyuan LIN, Xinyu YANG, Huigang LI, Wei SHEN, Di LU, Xiao XU",
journal="Journal of Zhejiang University Science B",
volume="24",
number="5",
pages="387-396",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200528"
}
%0 Journal Article
%T Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology
%A Zhihang HU
%A Modan YANG
%A Hao CHEN
%A Chiyu HE
%A Zuyuan LIN
%A Xinyu YANG
%A Huigang LI
%A Wei SHEN
%A Di LU
%A Xiao XU
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 5
%P 387-396
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200528
TY - JOUR
T1 - Double-negative T cells: a promising avenue of adoptive cell therapy in transplant oncology
A1 - Zhihang HU
A1 - Modan YANG
A1 - Hao CHEN
A1 - Chiyu HE
A1 - Zuyuan LIN
A1 - Xinyu YANG
A1 - Huigang LI
A1 - Wei SHEN
A1 - Di LU
A1 - Xiao XU
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 5
SP - 387
EP - 396
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200528
Abstract: Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer. In addition to the common mechanisms underlying tumor recurrence, another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis. Transplant oncology is an emerging field that addresses oncological challenges in transplantation. In this context, a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients. Double-negative T cells (DNTs) are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor (TCR) type. Among them, TCRαβ+ DNTs are considered to induce immune suppression in immune-mediated diseases, while TCRγδ+ DNTs are widely recognized as tumor killers. As a composite cell therapy, healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the host. In this work, we summarized the biological characteristics and functions of DNTs in oncology, immunology, and transplantation. Based on the multiple roles of DNTs, we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy (ACT).
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