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Qianming CHEN


Jiawen YONG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.957-973


Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives

Author(s):  Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China; more

Corresponding email(s):   qmchen@zju.edu.cn

Key Words:  Photobiomodulation therapy, Low-level laser therapy (LLLT), Low-intensity laser therapy (LILT), Orthodontic tooth movement, Orthodontics, Immunorthodontics

Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN. Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives[J]. Journal of Zhejiang University Science B, 2023, 24(11): 957-973.

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author="Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives
%A Jiawen YONG
%A Sabine GRÖGER
%A Andreas BRAUN
%A Xiaoyan CHEN
%A Sabine RUF
%A Qianming CHEN
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200706

T1 - Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives
A1 - Jiawen YONG
A1 - Sabine GRÖGER
A1 - Andreas BRAUN
A1 - Xiaoyan CHEN
A1 - Sabine RUF
A1 - Qianming CHEN
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 11
SP - 957
EP - 973
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2200706

Over the past decade, dramatic progress has been made in dental research areas involving laser therapy. The photobiomodulatory effect of laser light regulates the behavior of periodontal tissues and promotes damaged tissues to heal faster. Additionally, photobiomodulation therapy (PBMT), a non-invasive treatment, when applied in orthodontics, contributes to alleviating pain and reducing inflammation induced by orthodontic forces, along with improving tissue healing processes. Moreover, PBMT is attracting more attention as a possible approach to prevent the incidence of orthodontically induced inflammatory root resorption (OIIRR) during orthodontic treatment (OT) due to its capacity to modulate inflammatory, apoptotic, and anti-antioxidant responses. However, a systematic review revealed that PBMT has only a moderate grade of evidence-based effectiveness during orthodontic tooth movement (OTM) in relation to OIIRR, casting doubt on its beneficial effects. In PBMT-assisted orthodontics, delivering sufficient energy to the tooth root to achieve optimal stimulation is challenging due to the exponential attenuation of light penetration in periodontal tissues. The penetration of light to the root surface is another crucial unknown factor. Both the penetration depth and distribution of light in periodontal tissues are unknown. Thus, advanced approaches specific to orthodontic application of PBMT need to be established to overcome these limitations. This review explores possibilities for improving the application and effectiveness of PBMT during OTM. The aim was to investigate the current evidence related to the underlying mechanisms of action of PBMT on various periodontal tissues and cells, with a special focus on immunomodulatory effects during OTM.


勇佳汶1,2,Sabine GR?GER2,Julia VON BREMEN2,Márcia MARTINS MARQUES3,Andreas BRAUN4,陈小燕1,Sabine RUF2,陈谦明1


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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