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 ORCID:

Qianming CHEN

https://orcid.org/0000-0002-5371-4432

Jiawen YONG

https://orcid.org/0000-0002-3021-075X

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.957-973

http://doi.org/10.1631/jzus.B2200706


Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives


Author(s):  Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China; more

Corresponding email(s):   qmchen@zju.edu.cn

Key Words:  Photobiomodulation therapy, Low-level laser therapy (LLLT), Low-intensity laser therapy (LILT), Orthodontic tooth movement, Orthodontics, Immunorthodontics


Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN. Photobiomodulation therapy assisted orthodontic tooth movement: potential implications, challenges, and new perspectives[J]. Journal of Zhejiang University Science B, 2023, 24(11): 957-973.

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author="Jiawen YONG, Sabine GRÖGER, Julia VON BREMEN, Márcia MARTINS MARQUES, Andreas BRAUN, Xiaoyan CHEN, Sabine RUF, Qianming CHEN",
journal="Journal of Zhejiang University Science B",
volume="24",
number="11",
pages="957-973",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200706"
}

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%A Andreas BRAUN
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A1 - Márcia MARTINS MARQUES
A1 - Andreas BRAUN
A1 - Xiaoyan CHEN
A1 - Sabine RUF
A1 - Qianming CHEN
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DOI - 10.1631/jzus.B2200706


Abstract: 
Over the past decade, dramatic progress has been made in dental research areas involving laser therapy. The photobiomodulatory effect of laser light regulates the behavior of periodontal tissues and promotes damaged tissues to heal faster. Additionally, photobiomodulation therapy (PBMT), a non-invasive treatment, when applied in orthodontics, contributes to alleviating pain and reducing inflammation induced by orthodontic forces, along with improving tissue healing processes. Moreover, PBMT is attracting more attention as a possible approach to prevent the incidence of orthodontically induced inflammatory root resorption (OIIRR) during orthodontic treatment (OT) due to its capacity to modulate inflammatory, apoptotic, and anti-antioxidant responses. However, a systematic review revealed that PBMT has only a moderate grade of evidence-based effectiveness during orthodontic tooth movement (OTM) in relation to OIIRR, casting doubt on its beneficial effects. In PBMT-assisted orthodontics, delivering sufficient energy to the tooth root to achieve optimal stimulation is challenging due to the exponential attenuation of light penetration in periodontal tissues. The penetration of light to the root surface is another crucial unknown factor. Both the penetration depth and distribution of light in periodontal tissues are unknown. Thus, advanced approaches specific to orthodontic application of PBMT need to be established to overcome these limitations. This review explores possibilities for improving the application and effectiveness of PBMT during OTM. The aim was to investigate the current evidence related to the underlying mechanisms of action of PBMT on various periodontal tissues and cells, with a special focus on immunomodulatory effects during OTM.

激光光子生物调节疗法辅助正畸牙齿移动:潜在的作用、挑战与新观点

勇佳汶1,2,Sabine GR?GER2,Julia VON BREMEN2,Márcia MARTINS MARQUES3,Andreas BRAUN4,陈小燕1,Sabine RUF2,陈谦明1
1浙江大学医学院附属口腔医院,浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,口腔生物材料与器械浙江省工程研究中心,中国杭州市,310000
2德国尤斯图斯-李比希吉森大学医学院口腔正畸科,德国吉森市,35392
3巴西圣保罗大学牙学院,巴西圣保罗市,0550800
4德国亚琛工业大学牙槽外科、牙周与预防科,德国亚琛市,52074
摘要:口腔科激光治疗的研究在过去的十年里取得了巨大的进展。激光引发的光子生物调节效应能够调控牙周组织的生物学特性,促进损伤牙周组织更快愈合。光子生物调节疗法(PBMT)作为一种非侵入性治疗方式,有助于减轻正畸治疗引起的疼痛和牙周组织炎症,同时促进牙周组织愈合。此外,PBMT作为一种可通过改善炎症、调节细胞凋亡和抗氧化反应等生物学作用预防正畸导致的炎性牙根吸收(OIIRR)的新方法,受到越来越多研究者的关注。但也有研究表明,PBMT在正畸牙齿移动(OTM)过程中与OIIRR相关性的循证有效性仅为中等等级,这是由于光子在牙周组织中的穿透呈现指数衰减,难以向牙根表面提供足够的、适量的能量以达到最佳效果;另一方面,光是否能穿透牙周组织到达牙根表面也是影响激光在OIIRR治疗中的另外一个关键未知因素,光子在牙周组织中的穿透深度和能量分布强度尚不可知。因此,研究者需要克服以上局限性,以开发PBMT在正畸中的应用方法。本综述旨在阐述PBMT在OTM和预防OIIRR中的潜在作用及其相关机制,尤其是在OTM期间的免疫调节作用。

关键词:低水平激光治疗;激光光子生物调节疗法;低强度激光治疗;正畸牙齿移动;口腔正畸学;免疫口腔正畸学

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AbidiAH, MayallRE, RuanCX, et al., 2021. Immunomodulatory activity seen as a result of photobiomodulation therapy in stimulated primary human fibroblasts. Arch Oral Biol, 121:104968.

[2]AilioaieLM, LitscherG, 2020. Molecular and cellular mechanisms of arthritis in children and adults: new perspectives on applied photobiomodulation. Int J Mol Sci, 21(18):6565.

[3]al OklaN, BaderDMA, MakkiL, 2018. Effect of photobiomodulation on maxillary decrowding and root resorption: a randomized clinical trial. APOS Trends Orthod, 8(2):86-91.

[4]AlsarhanJ, el FeghaliR, AlkhudariT, et al., 2022. Can photobiomodulation support the management of temporomandibular joint pain? Molecular mechanisms and a systematic review of human clinical trials. Photonics, 9(6):420.

[5]AndersJJ, WuXJ, 2016. Comparison of light penetration of continuous wave 810 nm and superpulsed 904 nm wavelength light in anesthetized rats. Photomed Laser Surg, 34(9):418-424.

[6]AnicicMS, PerkovicV, GabrićD, et al., 2021. Effect of a double dose of photobiomodulation therapy on orthodontic pain caused by elastomeric separators. Australas Med J, 13(12):310-316.

[7]AroraD, YadavG, TripathiA, et al., 2021. Concepts and applications of LASERs in dentistry: an insight. Int J Oral Health Med Res, 4(5):75-79.

[8]AvciP, GuptaA, SadasivamM, et al., 2013. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Semin Cutan Med Surg, 32(1):41-52.

[9]BaricevicM, Mravak-StipeticM, MajstorovicM, et al., 2011. Oral mucosal lesions during orthodontic treatment. Int J Paediatr Dent, 21(2):96-102.

[10]BernhardtMK, SouthardKA, BattersonKD, et al., 2001. The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain. Am J Orthod Dentofacial Orthop, 120(1):20-27.

[11]BlairJM, ZhengY, DunstanCR, 2007. RANK ligand. Int J Biochem Cell Biol, 39(6):1077-1081.

[12]CarrollJD, MilwardMR, CooperPR, et al., 2014. Developments in low level light therapy (LLLT) for dentistry. Dent Mater, 30(5):465-475.

[13]ChanA, ArmatiP, MoorthyAP, 2012. Pulsed Nd: YAG laser induces pulpal analgesia: a randomized clinical trial. J Dent Res, 91(7 Suppl.):S79-S84.

[14]ChangB, QiuHX, ZhaoHY, et al., 2019. The effects of photobiomodulation on MC3T3-E1 cells via 630 nm and 810 nm light-emitting diode. Med Sci Monit, 25:8744-8752.

[15]ChenCH, WangCZ, WangYH, et al., 2014. Effects of low-level laser therapy on M1-related cytokine expression in monocytes via histone modification. Mediat Inflamm, 2014:625048.

[16]ChenQM, WangYH, ShuaiJ, 2023. Current status and future prospects of stomatology research. J Zhejiang Univ-Sci B (Biomed & Biotechnol), Online.

[17]ChowRT, JohnsonMI, Lopes-MartinsRA, et al., 2009. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. Lancet, 374(9705):1897-1908.

[18]ChungH, DaiTH, SharmaSK, et al., 2012. The nuts and bolts of low-level laser (light) therapy. Ann Biomed Eng, 40(2):516-533.

[19]CorazzaAV, JorgeJ, KurachiC, et al., 2007. Photobiomodulation on the angiogenesis of skin wounds in rats using different light sources. Photomed Laser Surg, 25(2):102-106.

[20]CronshawM, ParkerS, AnagnostakiE, et al., 2020. Photobiomodulation dose parameters in dentistry: a systematic review and meta-analysis. Dent J (Basel), 8(4):114.

[21]CruzDR, KoharaEK, RibeiroMS, et al., 2004. Effects of low-intensity laser therapy on the orthodontic movement velocity of human teeth: a preliminary study. Lasers Surg Med, 35(2):117-120.

[22]CuryV, MorettiAIS, AssisL, et al., 2013. Low level laser therapy increases angiogenesis in a model of ischemic skin flap in rats mediated by VEGF, HIF-1α and MMP-2. J Photochem Photobiol B Biol, 125:164-170.

[23]da Silva SousaMV, ScanaviniMA, SannomiyaEK, et al., 2011. Influence of low-level laser on the speed of orthodontic movement. Photomed Laser Surg, 29(3):191-196.

[24]DakshinaCK, HanumanthaiahS, RamaiahPT, et al., 2019. Efficacy of low-level laser therapy in increasing the rate of orthodontic tooth movement: a randomized control clinical trial. World J Dent, 10(3):177-180.

[25]de Brito SousaK, RodriguesMFSD, de Souza SantosD, et al., 2020. Differential expression of inflammatory and anti-inflammatory mediators by M1 and M2 macrophages after photobiomodulation with red or infrared lasers. Lasers Med Sci, 35(2):337-343.

[26]de FreitasLF, HamblinMR, 2016. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron, 22(3):348-364.

[27]DillenburgCS, AlmeidaLO, MartinsMD, et al., 2014. Laser phototherapy triggers the production of reactive oxygen species in oral epithelial cells without inducing DNA damage. J Biomed Opt, 19(4):048002.

[28]DimmelerS, LottspeichF, BrüneB, 1992. Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem, 267(24):16771-16774.

[29]DomínguezA, VelásquezSA, 2021. Acceleration of dental movement by photobiomodulation: how does it happen? Photobiomodul Photomed Laser Surg, 39(6):379-380.

[30]DomínguezA, BallesterosRE, ViáfaraJH, et al., 2013. Effect of low level laser therapy on dental pulp during orthodontic movement. World J Methodol, 3(2):19-26.

[31]Domínguez CamachoA, Bravo ReyesM, Velasquez CujarSA, 2020a. A systematic review of the effective laser wavelength range in delivering photobiomodulation for pain relief in active orthodontic treatment. Int Orthod, 18(4):684-695.

[32]Domínguez CamachoA, Montoya GuzmánD, Velásquez CujarSA, 2020b. Effective wavelength range in photobiomodulation for tooth movement acceleration in orthodontics: a systematic review. Photobiomodul Photomed Laser Surg, 38(10):581-590.

[33]DompeC, MoncrieffL, MatysJ, et al., 2020. Photobiomodulation—underlying mechanism and clinical applications. J Clin Med, 9(6):1724.

[34]Doshi-MehtaG, Bhad-PatilWA, 2012. Efficacy of low-intensity laser therapy in reducing treatment time and orthodontic pain: a clinical investigation. Am J Orthod Dentofacial Orthop, 141(3):289-297.

[35]DrapierJC, HirlingH, WietzerbinJ, et al., 1993. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J, 12(9):3643-3649.

[36]DrapierJC, Hibbs JB Jr, 1996. Aconitases: a class of metalloproteins highly sensitive to nitric oxide synthesis. In: Packer L (Ed.), Methods in Enzymology, vol. 269. Academic Press, NY, p.26-36.

[37]EellsJT, HenryMM, SummerfeltP, et al., 2003. Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc Natl Acad Sci USA, 100(6):3439-3444.

[38]EellsJT, Wong-RileyMTT, VerHoeveJ, et al., 2004. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion, 4(5-6):559-567.

[39]EidFY, El-KenanyWA, MowafyMI, et al., 2022. The influence of two photobiomodulation protocols on orthodontically induced inflammatory root resorption (a randomized controlled clinical trial). BMC Oral Health, 22:221.

[40]EkizerA, TürkerG, UysalT, et al., 2016. Light emitting diode mediated photobiomodulation therapy improves orthodontic tooth movement and miniscrew stability: a randomized controlled clinical trial. Lasers Surg Med, 48(10):936-943.

[41]EnaiaM, BockN, RufS, 2011. White-spot lesions during multibracket appliance treatment: a challenge for clinical excellence. Am J Orthod Dentofacial Orthop, 140(1):e17-e24.

[42]EslamianL, Borzabadi-FarahaniA, Hassanzadeh-AzhiriA, et al., 2014. The effect of 810-nm low-level laser therapy on pain caused by orthodontic elastomeric separators. Lasers Med Sci, 29(2):559-564.

[43]FariaLV, AndradeIN, dos AnjosLMJ, et al., 2020. Photobiomodulation can prevent apoptosis in cells from mouse periodontal ligament. Lasers Med Sci, 35(8):1841-1848.

[44]FernandesMRU, SuzukiSS, SuzukiH, et al., 2019. Photobiomodulation increases intrusion tooth movement and modulates IL-6, IL-8 and IL-1β expression during orthodontic

[45]ally bone remodeling. J Biophotonics, 12(10):e201800311.

[46]FujimotoK, KiyosakiT, MitsuiN, et al., 2010. Low-intensity laser irradiation stimulates mineralization via increased BMPs in MC3T3-E1 cells. Lasers Surg Med, 42(6):519-526.

[47]FujitaS, YamaguchiM, UtsunomiyaT, et al., 2008. Low-energy laser stimulates tooth movement velocity via expression of RANK and RANKL. Orthod Craniofac Res, 11(3):143-155.

[48]GamaSKC, HabibFAL, de CarvalhoJS, et al., 2010. Tooth movement after infrared laser phototherapy: clinical study in rodents. Photomed Laser Surg, 28(S2):S-79-S-83.

[49]GencG, Kocadereliİ, TasarF, et al., 2013. Effect of low-level laser therapy (LLLT) on orthodontic tooth movement. Lasers Med Sci, 28(1):41-47.

[50]GholamiL, HendiSS, SaidijamM, et al., 2022. Near-infrared 940-nm diode laser photobiomodulation of inflamed periodontal ligament stem cells. Lasers Med Sci, 37(1):449-459.

[51]GoulartCS, NouerPRA, MouramartinsL, et al., 2006. Photoradiation and orthodontic movement: experimental study with canines. Photomed Laser Surg, 24(2):192-196.

[52]GoymenM, GulecA, 2020. Effect of photobiomodulation therapies on the root resorption associated with orthodontic forces: a pilot study using micro computed tomography. Clin Oral Invest, 24(4):1431-1438.

[53]HamblinMR, 2016. Photobiomodulation or low-level laser therapy. J Biophoton, 9(11-12):1122-1124.

[54]HamblinMR, 2017. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS Biophys, 4(3):337-361.

[55]HamblinMR, 2018. Mechanisms and mitochondrial redox signaling in photobiomodulation. Photochem Photobiol, 94(2):199-212.

[56]HamblinMR, CarrollJD, AranyP, 2015. Mechanisms for Low-Light Therapy X. SPIE ‒ the International Society for Optics and Photonics, San Francisco, California, USA.

[57]HarazakiM, TakahashiH, ItoA, et al., 1998. Soft laser irradiation induced pain reduction in orthodontic treatment. Bull Tokyo Dent Coll, 39(2):95-101.

[58]HashimotoF, KobayashiY, MatakiS, et al., 2001. Administration of osteocalcin accelerates orthodontic tooth movement induced by a closed coil spring in rats. Eur J Orthod, 23(5):535-545.

[59]HendersonTA, MorriesLD, 2015. Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain? Neuropsychiatr Dis Treat, 11:2191-2208.

[60]HuangYY, SharmaSK, CarrollJ, et al., 2011. Biphasic dose response in low level light therapy ‒ an update. Dose Response, 9(4):602-618.

[61]KatagiriT, TakahashiN, 2002. Regulatory mechanisms of osteoblast and osteoclast differentiation. Oral Dis, 8(3):147-159.

[62]KateRJ, RubattS, EnwemekaCS, et al., 2018. Optimal laser phototherapy parameters for pain relief. Photomed Laser Surg, 36(7):354-362.

[63]KauCH, KantarciA, ShaughnessyT, et al., 2013. Photobiomodulation accelerates orthodontic alignment in the early phase of treatment. Prog Orthod, 14:30.

[64]KawakamiM, Takano-YamamotoT, 2004. Local injection of 1,25-dihydroxyvitamin D3 enhanced bone formation for tooth stabilization after experimental tooth movement in rats. J Bone Miner Metab, 22(6):541-546.

[65]KawasakiK, ShimizuN, 2000. Effects of low-energy laser irradiation on bone remodeling during experimental tooth movement in rats. Lasers Surg Med, 26(3):282-291.

[66]KeijzerM, JacquesSL, PrahlSA, et al., 1989. Light distributions in artery tissue: Monte Carlo simulations for finite-diameter laser beams. Lasers Surg Med, 9(2):148-154.

[67]KhawCMA, DalciO, FoleyM, et al., 2018. Physical properties of root cementum: part 27. Effect of low-level laser therapy on the repair of orthodontically induced inflammatory root resorption: a double-blind, split-mouth, randomized controlled clinical trial. Am J Orthod Dentofacial Orthop, 154(3):326-336.

[68]KimSJ, MoonSU, KangSG, et al., 2009. Effects of low-level laser therapy after Corticision on tooth movement and paradental remodeling. Lasers Surg Med, 41(7):524-533.

[69]KimYD, KimSS, KimTG, et al., 2007. Effect of low level laser treatment during tooth movement-immunohistochemical study of RANKL, RANK, OPG: an experimental study in rats. Laser Phys Lett, 4(8):616-623.

[70]LabonteAC, Tosello-TrampontAC, HahnYS, 2014. The role of macrophage polarization in infectious and inflammatory diseases. Mol Cells, 37(4):275-285.

[71]LanzafameRJ, StadlerI, KurtzAF, et al., 2007. Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model. Lasers Surg Med, 39(6):534-542.

[72]LawSLS, SouthardKA, LawAS, et al., 2000. An evaluation of preoperative ibuprofen for treatment of pain associated with orthodontic separator placement. Am J Orthod Dentofacial Orthop, 118(6):629-635.

[73]LeeJH, ChiangMH, ChenPH, et al., 2018. Anti-inflammatory effects of low-level laser therapy on human periodontal ligament cells: in vitro study. Lasers Med Sci, 33(3):469-477.

[74]LepoivreM, FieschiF, CovesJ, et al., 1991. Inactivation of ribonucleotide reductase by nitric oxide. Biochem Biophys Res Commun, 179(1):442-448.

[75]LiaoWT, HungCH, LiangSS, et al., 2021. Anti-inflammatory effects induced by near-infrared light irradiation through M2 macrophage polarization. J Invest Dermatol, 141(8):2056-2066.e10.

[76]LimHM, LewKKK, TayDKL, 1995. A clinical investigation of the efficacy of low level laser therapy in reducing orthodontic postadjustment pain. Am J Orthod Dentofacial Orthop, 108(6):614-622.

[77]LimpanichkulW, GodfreyK, SrisukN, et al., 2006. Effects of low-level laser therapy on the rate of orthodontic tooth movement. Orthod Craniofac Res, 9(1):38-43.

[78]MarcosRL, Leal JuniorECP, de Moura MessiasF, et al., 2011. Infrared (810 nm) low-level laser therapy in rat achilles tendinitis: a consistent alternative to drugs. Photochem Photobiol, 87(6):1447-1452.

[79]MartinezFO, HelmingL, GordonS, 2009. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol, 27:451-483.

[80]MashaRT, HoureldNN, AbrahamseH, 2013. Low-intensity laser irradiation at 660 nm stimulates transcription of genes involved in the electron transport chain. Photomed Laser Surg, 31(2):47-53.

[81]MesterE, NagylucskayS, WaidelichW, et al., 1978. Effects of direct laser radiation on human lymphocytes. Arch Dermatol Res, 263(3):241-245 (in German).

[82]MgGuffPE, DeterlingRAJr, GottliebLS, 1965. Tumoricidal effect of laser energy on experimental and human malignant tumors. N Engl J Med, 273(9):490-492.

[83]MirhashemiA, RasouliS, ShahiS, et al., 2021. Efficacy of photobiomodulation therapy for orthodontic pain control following the placement of elastomeric separators: a randomized clinical trial. J Lasers Med Sci, 12:e8.

[84]MistryD, DalciO, PapageorgiouSN, et al., 2020. The effects of a clinically feasible application of low-level laser therapy on the rate of orthodontic tooth movement: a triple-blind, split-mouth, randomized controlled trial. Am J Orthod Dentofacial Orthop, 157(4):444-453.

[85]MizutaniK, MusyaY, WakaeK, et al., 2004. A clinical study on serum prostaglandin E2 with low-level laser therapy. Photomed Laser Surg, 22(6):537-539.

[86]MoriyamaY, NguyenJ, AkensM, et al., 2009. In vivo effects of low level laser therapy on inducible nitric oxide synthase. Lasers Surg Med, 41(3):227-231.

[87]MuradF, 2004. Discovery of some of the biological effects of nitric oxide and its role in cell signaling. Biosci Rep, 24(4-5):452-474.

[88]MylonaV, AnagnostakiE, ChiniforushN, et al., 2022. Photobiomodulation effects on periodontal ligament stem cells: a systematic review of in vitro studies. Curr Stem Cell Res Ther, Online.

[89]NaS, TruongvoT, JiangFF, et al., 2018. Dose analysis of photobiomodulation therapy on osteoblast, osteoclast, and osteocyte. J Biomed Opt, 23(7):075008.

[90]NayyerN, TripathiT, GaneshG, et al., 2022. Impact of photobiomodulation on external root resorption during orthodontic tooth movement in humans ‒ a systematic review and meta-analysis. J Oral Biol Craniofac Res, 12(4):469-480.

[91]NgD, ChanAK, PapadopoulouAK, et al., 2018. The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial. Eur J Orthod, 40(3):317-325.

[92]NimeriG, KauCH, Abou-KheirNS, et al., 2013. Acceleration of tooth movement during orthodontic treatment ‒ a frontier in orthodontics. Prog Orthod, 14:42.

[93]NimeriG, KauCH, CoronaR, et al., 2014. The effect of photobiomodulation on root resorption during orthodontic treatment. Clin Cosmet Investig Dent, 6:1-8.

[94]OsipovAN, MachnevaTV, BuravlevEA, et al., 2018. Effects of laser radiation on mitochondria and mitochondrial proteins subjected to nitric oxide. Front Med, 5:112.

[95]OzawaY, ShimizuN, KariyaG, et al., 1998. Low-energy laser irradiation stimulates bone nodule formation at early stages of cell culture in rat calvarial cells. Bone, 22(4):347-354.

[96]PanhocaVH, LizarelliRDF, NunezSC, et al., 2015. Comparative clinical study of light analgesic effect on temporomandibular disorder (TMD) using red and infrared led therapy. Lasers Med Sci, 30(2):815-822.

[97]PellicioliACA, MartinsMD, DillenburgCS, et al., 2014. Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of rapamycin signaling pathway. J Biomed Opt, 19(2):028002.

[98]Popa-WagnerA, MitranS, SivanesanS, et al., 2013. ROS and brain diseases: the good, the bad, and the ugly. Oxid Med Cell Longev, 2013:963520.

[99]PruittT, CarterC, WangXL, et al., 2022. Photobiomodulation at different wavelengths boosts mitochondrial redox metabolism and hemoglobin oxygenation: lasers vs. light-emitting diodes in vivo. Metabolites, 12(2):103.

[100]RyuJJ, YooS, KimKY, et al., 2010. Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception. J Dent Res, 89(12):1455-1460.

[101]SaitoS, ShimizuN, 1997. Stimulatory effects of low-power laser irradiation on bone regeneration in midpalatal suture during expansion in the rat. Am J Orthod Dentofacial Orthop, 111(5):525-532.

[102]SalehpourF, MahmoudiJ, KamariF, et al., 2018. Brain photobiomodulation therapy: a narrative review. Mol Neurobiol, 55(8):6601-6636.

[103]SaygunI, KaracayS, SerdarM, et al., 2008. Effects of laser irradiation on the release of basic fibroblast growth factor (bFGF), insulin like growth factor-1 (IGF-1), and receptor of IGF-1 (IGFBP3) from gingival fibroblasts. Lasers Med Sci, 23(2):211-215.

[104]SeifiM, EslamiB, SaffarAS, 2003. The effect of prostaglandin E2 and calcium gluconate on orthodontic tooth movement and root resorption in rats. Eur J Orthod, 25(2):199-204.

[105]SeifiM, ShafeeiHA, DaneshdoostS, et al., 2007. Effects of two types of low-level laser wave lengths (850 and 630 nm) on the orthodontic tooth movements in rabbits. Lasers Med Sci, 22(4):261-264.

[106]SeoBM, MiuraM, GronthosS, et al., 2004. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet, 364(9429):149-155.

[107]SfondriniMF, VitaleM, PinheiroALB, et al., 2020. Photobiomodulation and pain reduction in patients requiring orthodontic band application: randomized clinical trial. Biomed Res Int, 2020:7460938.

[108]ShaughnessyT, KantarciA, KauCH, et al., 2016. Intraoral photobiomodulation-induced orthodontic tooth alignment: a preliminary study. BMC Oral Health, 16:3.

[109]StamlerJS, SimonDI, OsborneJA, et al., 1992. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci USA, 89(1):444-448.

[110]SuCT, ChenCM, ChenCC, et al., 2020. Dose analysis of photobiomodulation therapy in stomatology. Evid Based Complement Alternat Med, 2020:8145616.

[111]SveltoO, LonghiS, ValleG, et al., 2007. Lasers and coherent light sources. In: Träger F (Ed.), Springer Handbook of Lasers and Optics. Springer, New York, p.583-936.

[112]SzymanskaJ, GoralczykK, KlaweJJ, et al., 2013. Phototherapy with low-level laser influences the proliferation of endothelial cells and vascular endothelial growth factor and transforming growth factor-beta secretion. J Physiol Pharmacol, 64(3):387-391.

[113]TalicNF, 2011. Adverse effects of orthodontic treatment: a clinical perspective. Saudi Dent J, 23(2):55-59.

[114]TopolskiF, MoroA, CorrerGM, et al., 2018. Optimal management of orthodontic pain. J Pain Res, 11:589-598.

[115]TunérJ, HosseinpourS, FekrazadR, 2019. Photobiomodulation in temporomandibular disorders. Photobiomodul Photomed Laser Surg, 37(12):826-836.

[116]UribeF, PadalaS, AllareddyV, et al., 2014. Patients’, parents’, and orthodontists’ perceptions of the need for and costs of additional procedures to reduce treatment time. Am J Orthod Dentofacial Orthop, 145(4 Suppl):S65-S73.

[117]ViegasVN, AbreuMER, ViezzerC, et al., 2007. Effect of low-level laser therapy on inflammatory reactions during wound healing: comparison with meloxicam. Photomed Laser Surg, 25(6):467-473.

[118]von LedenRE, CooneySJ, FerraraTM, et al., 2013. 808 nm wavelength light induces a dose-dependent alteration in microglial polarization and resultant microglial induced neurite growth. Lasers Surg Med, 45(4):253-263.

[119]WagnerVP, MeurerL, MartinsMAT, et al., 2013. Influence of different energy densities of laser phototherapy on oral wound healing. J Biomed Opt, 18(12):128002.

[120]WagnerVP, CurraM, WebberLP, et al., 2016. Photobiomodulation regulates cytokine release and new blood vessel formation during oral wound healing in rats. Lasers Med Sci, 31(4):665-671.

[121]YamaguchiM, FujitaS, YoshidaT, et al., 2007. Low-energy laser irradiation stimulates the tooth movement velocity via expression of M-CSF and c-fms. Orthodontic Waves, 66(4):139-148.

[122]YamaguchiM, HayashiM, FujitaS, et al., 2010. Low-energy laser irradiation facilitates the velocity of tooth movement and the expressions of matrix metalloproteinase-9, cathepsin K, and alpha(v) beta(3) integrin in rats. Eur J Orthod, 32(2):131-139.

[123]YanWX, ChowR, ArmatiPJ, 2011. Inhibitory effects of visible 650-nm and infrared 808-nm laser irradiation on somatosensory and compound muscle action potentials in rat sciatic nerve: implications for laser-induced analgesia. J Peripher Nerv Syst, 16(2):130-135.

[124]YassaeiS, FekrazadR, ShahrakiN, 2013. Effect of low level laser therapy on orthodontic tooth movement: a review article. J Dent (Tehran), 10(3):264-272.

[125]YavagalCM, MatondkarSP, YavagalPC, 2021. Efficacy of laser photobiomodulation in accelerating orthodontic tooth movement in children: a systematic review with meta-analysis. Int J Clin Pediatr Dent, 14(S1):S91-S97.

[126]YongJW, von BremenJ, Ruiz-HeilandG, et al., 2021a. Adiponectin as well as compressive forces regulate in vitro β-catenin expression on cementoblasts via mitogen-activated protein kinase signaling activation. Front Cell Dev Biol, 9:645005.

[127]YongJW, von BremenJ, GroegerS, et al., 2021b. Hypoxia-inducible factor 1-alpha acts as a bridge factor for crosstalk between ERK1/2 and caspases in hypoxia-induced apoptosis of cementoblasts. J Cell Mol Med, 25(20):9710-9723.

[128]YongJW, GrögerS, MeyleJ, et al., 2022a. Immunorthodontics: role of HIF-1α in the regulation of (peptidoglycan-induced) PD-L1 expression in cementoblasts under compressive force. Int J Mol Sci, 23(13):6977.

[129]YongJW, GroegerS, von BremenJ, et al., 2022b. Ciliary neurotrophic factor (CNTF) and its receptors signal regulate cementoblasts apoptosis through a mechanism of ERK1/2 and caspases signaling. Int J Mol Sci, 23(15):8335.

[130]YongJW, GrögerS, von BremenJ, et al., 2022c. Ciliary neurotrophic factor (CNTF) inhibits in vitro cementoblast mineralization and induces autophagy, in part by STAT3/ERK commitment. Int J Mol Sci, 23(16):9311.

[131]YongJW, GrögerS, von BremenJ, et al., 2022d. Immuno

[132]rthodontics: PD-L1, a novel immunomodulator in cementoblasts, is regulated by HIF-1α under hypoxia. Cells, 11(15):2350.

[133]YongJW, GroegerS, MeyleJ, et al., 2022e. MAPK and β-catenin signaling: implication and interplay in orthodontic tooth movement. Front Biosci (Landmark Ed), 27(2):54.

[134]YongJW, LiPP, MizrahiIK, et al., 2022f. Effect of low-level Er: YAG (2940 nm) laser irradiation on the photobiomodulation of mitogen-activated protein kinase cellular signaling pathway of rodent cementoblasts. Front Biosci (Landmark Ed), 27(2):62.

[135]YongJW, GroegerSE, RufS, et al., 2023. Influence of leptin and compression in GAS-6 mediated homeostasis of periodontal ligament cell. Oral Dis, 29(3):1172-1183.

[136]YoshidaT, YamaguchiM, UtsunomiyaT, et al., 2009. Low-energy laser irradiation accelerates the velocity of tooth movement via stimulation of the alveolar bone remodeling. Orthod Craniofac Res, 12(4):289-298.

[137]YoussefM, AshkarS, HamadeE, et al., 2008. The effect of low-level laser therapy during orthodontic movement: a preliminary study. Lasers Med Sci, 23(1):27-33.

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