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Guoli YANG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.943-956


Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine

Author(s):  Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China

Corresponding email(s):   guo_li1977@zju.edu.cn

Key Words:  Silk fibroin, Coating, Surface modification, Notch signaling pathway

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Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG. Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine[J]. Journal of Zhejiang University Science B, 2023, 24(11): 943-956.

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author="Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
%A Jinxing HU
%A Zhiwei JIANG
%A Guoli YANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 11
%P 943-956
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300003

T1 - Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
A1 - Jinxing HU
A1 - Zhiwei JIANG
A1 - Jing ZHANG
A1 - Guoli YANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 11
SP - 943
EP - 956
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300003

silk fibroin (SF) as a natural biopolymer has become a popular material for biomedical applications due to its minimal immunogenicity, tunable biodegradability, and high biocompatibility. Nowadays, various techniques have been developed for the applications of SF in bioengineering. Most of the literature reviews focus on the SF-based biomaterials and their different forms of applications such as films, hydrogels, and scaffolds. SF is also valuable as a coating on other substrate materials for biomedicine; however, there are few reviews related to SF-coated biomaterials. Thus, in this review, we focused on the surface modification of biomaterials using SF coatings, demonstrated their various preparation methods on substrate materials, and introduced the latest procedures. The diverse applications of SF coatings for biomedicine are discussed, including bone, ligament, skin, mucosa, and nerve regeneration, and dental implant surface modification. SF coating is conducive to inducing cell adhesion and migration, promoting hydroxyapatite (HA) deposition and matrix mineralization, and inhibiting the notch signaling pathway, making it a promising strategy for bone regeneration. In addition, SF-coated composite scaffolds can be considered prospective candidates for ligament regeneration after injury. SF coating has been proven to enhance the mechanical properties of the substrate material, and render integral stability to the dressing material during the regeneration of skin and mucosa. Moreover, SF coating is a potential strategy to accelerate nerve regeneration due to its dielectric properties, mechanical flexibility, and angiogenesis promotion effect. In addition, SF coating is an effective and popular means for dental implant surface modification to promote osteogenesis around implants made of different materials. Thus, this review can be of great benefit for further improvements in SF-coated biomaterials, and will undoubtedly contribute to clinical transformation in the future.




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