Full Text:   <436>

Summary:  <129>

CLC number: 

On-line Access: 2023-11-14

Received: 2023-01-02

Revision Accepted: 2023-04-18

Crosschecked: 2023-11-15

Cited: 0

Clicked: 511

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Guoli YANG

https://orcid.org/0000-0002-1780-8757

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.11 P.943-956

http://doi.org/10.1631/jzus.B2300003


Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine


Author(s):  Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG

Affiliation(s):  Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China

Corresponding email(s):   guo_li1977@zju.edu.cn

Key Words:  Silk fibroin, Coating, Surface modification, Notch signaling pathway


Share this article to: More |Next Article >>>

Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG. Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine[J]. Journal of Zhejiang University Science B, 2023, 24(11): 943-956.

@article{title="Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine",
author="Jinxing HU, Zhiwei JIANG, Jing ZHANG, Guoli YANG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="11",
pages="943-956",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300003"
}

%0 Journal Article
%T Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
%A Jinxing HU
%A Zhiwei JIANG
%A Jing ZHANG
%A Guoli YANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 11
%P 943-956
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300003

TY - JOUR
T1 - Application of silk fibroin coatings for biomaterial surface modification: a silk road for biomedicine
A1 - Jinxing HU
A1 - Zhiwei JIANG
A1 - Jing ZHANG
A1 - Guoli YANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 11
SP - 943
EP - 956
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300003


Abstract: 
silk fibroin (SF) as a natural biopolymer has become a popular material for biomedical applications due to its minimal immunogenicity, tunable biodegradability, and high biocompatibility. Nowadays, various techniques have been developed for the applications of SF in bioengineering. Most of the literature reviews focus on the SF-based biomaterials and their different forms of applications such as films, hydrogels, and scaffolds. SF is also valuable as a coating on other substrate materials for biomedicine; however, there are few reviews related to SF-coated biomaterials. Thus, in this review, we focused on the surface modification of biomaterials using SF coatings, demonstrated their various preparation methods on substrate materials, and introduced the latest procedures. The diverse applications of SF coatings for biomedicine are discussed, including bone, ligament, skin, mucosa, and nerve regeneration, and dental implant surface modification. SF coating is conducive to inducing cell adhesion and migration, promoting hydroxyapatite (HA) deposition and matrix mineralization, and inhibiting the notch signaling pathway, making it a promising strategy for bone regeneration. In addition, SF-coated composite scaffolds can be considered prospective candidates for ligament regeneration after injury. SF coating has been proven to enhance the mechanical properties of the substrate material, and render integral stability to the dressing material during the regeneration of skin and mucosa. Moreover, SF coating is a potential strategy to accelerate nerve regeneration due to its dielectric properties, mechanical flexibility, and angiogenesis promotion effect. In addition, SF coating is an effective and popular means for dental implant surface modification to promote osteogenesis around implants made of different materials. Thus, this review can be of great benefit for further improvements in SF-coated biomaterials, and will undoubtedly contribute to clinical transformation in the future.

丝素蛋白涂层在生物材料表面修饰中的应用:生物医学领域的丝绸之路

胡金星,姜治伟,张晶,杨国利
浙江大学医学院附属口腔医院,浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,口腔生物材料与器械浙江省工程研究中心,中国杭州市,310000
摘要:作为一种天然的生物聚合物,丝素蛋白(SF)因其具有极低的免疫原性、可调节的生物降解性和优良的生物相容性而成为了生物医学领域的热门材料。目前,SF在生物工程的应用已经利用了多种技术。大多数文献综述着眼在基于SF的生物材料及其不同的应用形式,如薄膜、水凝胶和支架。当SF用作其他生物医学基底材料上的涂层时也很有利用价值;然而,关于含SF涂层的生物材料的综述较少。因此,本文收集了SF涂层在生物材料表面改性中应用的研究进展,阐述了其在生物材料表面修饰的各种制备方法,并介绍了生物材料表面改性的最新进展。此外,本文还讨论了SF涂层在生物医学领域的广泛应用,包括骨再生、韧带再生、皮肤和黏膜再生、神经再生及口腔种植体表面修饰。SF涂层有利于诱导细胞黏附和迁移,促进羟基磷灰石沉积和基质矿化,抑制Notch信号通路,是一种很有前景的骨再生策略。同时,SF涂层复合支架是韧带损伤后再生的候选材料。SF涂层可以提高基底材料的机械性能,并使敷料材料在皮肤和黏膜再生过程中具有整体稳定性。此外,SF涂层由于其只有介电特性、机械柔韧性和促进血管生成的作用,能够成为一种加速神经再生的潜在材料。SF涂层也是口腔种植体表面改性的一种有效手段,可以促进不同材料种植体周围的成骨。本综述对SF涂层生物材料的改进具有一定参考价值,并且有助于实现未来的临床转化。

关键词:丝素蛋白;涂层;表面改性;Notch信号通路

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AiCC, ShengDD, ChenJ, et al., 2017. Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis. Int J Nanomedicine, 12:7737-7750.

[2]AltmanGH, DiazF, JakubaC, et al., 2003. Silk-based biomaterials. Biomaterials, 24(3):401-416.

[3]ArastehS, KazemnejadS, KhanjaniS, et al., 2016. Fabrication and characterization of nano-fibrous bilayer composite for skin regeneration application. Methods, 99:3-12.

[4]ArkhangelskiyA, ManiglioD, BucciarelliA, et al., 2021. Plasma-assisted deposition of silk fibroin on different surfaces. Adv Mater Interfaces, 8(13):2100324.

[5]AydogduH, KeskinD, BaranET, et al., 2016. Pullulan microcarriers for bone tissue regeneration. Mater Sci Eng C, 63:439-449.

[6]Baranowska-KorczycA, HudeckiA, KamińskaI, et al., 2021. Silk powder from cocoons and woven fabric as a potential bio-modifier. Materials, 14(22):6919.

[7]BarikA, RaySK, ByramPK, et al., 2020. Extensive early mineralization of pre-osteoblasts, inhibition of osteoclastogenesis and faster peri-implant bone healing in osteoporotic rat model: principle effectiveness of bone-specific delivery of Tibolone as evaluated in vitro and in vivo. Biomed Mater, 15(6):064102.

[8]BayraktarO, MalayÖ, ÖzgaripY, et al., 2005. Silk fibroin as a novel coating material for controlled release of theophylline. Eur J Pharm Biopharm, 60(3):373-381.

[9]BharadwazA, JayasuriyaAC, 2020. Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration. Mater Sci Eng C, 110:110698.

[10]BiXW, LiLH, MaoZN, et al., 2020. The effects of silk layer-by-layer surface modification on the mechanical and structural retention of extracellular matrix scaffolds. Biomater Sci, 8(14):4026-4038.

[11]BoniBOO, BakadiaBM, OsiAR, et al., 2022. Immune response to silk sericin-fibroin composites: potential immunogenic elements and alternatives for immunomodulation. Macromol Biosci, 22:2100292.

[12]BrånemarkPI, 1983. Osseointegration and its experimental background. J Prosthet Dent, 50(3):399-410.

[13]CaoY, LiuFQ, ChenYL, et al., 2017. Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying. Sci Rep, 7:11913.

[14]Carrasco-TorresG, Valdés-MadrigalMA, Vásquez-GarzónVR, et al., 2019. Effect of silk fibroin on cell viability in electrospun scaffolds of polyethylene oxide. Polymers, 11(3):451.

[15]ChenJ, ZhuangA, ShaoHL, et al., 2017. Robust silk fibroin/bacterial cellulose nanoribbon composite scaffolds with radial lamellae and intercalation structure for bone regeneration. J Mater Chem B, 5(20):3640-3650.

[16]ChengX, DengDM, ChenLL, et al., 2020. Electrodeposited assembly of additive-free silk fibroin coating from pre-assembled nanospheres for drug delivery. ACS Appl Mater Interfaces, 12(10):12018-12029.

[17]ChengX, LongDP, ChenLL, et al., 2021. Electrophoretic deposition of silk fibroin coatings with pre-defined architecture to facilitate precise control over drug delivery. Bioact Mater, 6(11):4243-4254.

[18]ChouhanD, MandalBB, 2020. Silk biomaterials in wound healing and skin regeneration therapeutics: from bench to bedside. Acta Biomater, 103:24-51.

[19]dal PràI, PetriniP, ChiariniA, et al., 2004. Silk fibroin-coated three-dimensional polyurethane scaffolds for tissue engineering: interactions with normal human fibroblasts. Tissue Eng Part A, 9(6):1113-1121.

[20]EallaKKR, VeeraraghavanVP, RavulaNR, et al., 2022. Silk hydrogel for tissue engineering: a review. J Contemp Dent Pract, 23(4):467-477.

[21]EliaR, MichelsonCD, PereraAL, et al., 2015. Electrodeposited silk coatings for bone implants. J Biomed Mater Res Part B Appl Biomater, 103(8):1602-1609.

[22]FanYQ, LiX, YangRJ, 2018. The surface modification methods for constructing polymer-coated stents. Int J Polym Sci, 2018:3891686.

[23]HasturkO, SahooJK, KaplanDL, 2020. Synthesis and characterization of silk ionomers for layer-by-layer electrostatic deposition on individual mammalian cells. Biomacromolecules, 21(7):2829-2843.

[24]HolzapfelBM, RudertM, HutmacherDW, 2017. Scaffold-based bone tissue engineering. Orthopade, 46(8):701-710 (in German).

[25]JiangJ, AiCC, ZhanZF, et al., 2016. Enhanced fibroblast cellular ligamentization process to polyethylene terepthalate artificial ligament by silk fibroin coating. Artif Organs, 40(4):385-393.

[26]JosephE, RajputSS, PatilS, et al., 2021. Mechanism of adhesion of natural polymer coatings to chemically modified siloxane polymer. Langmuir, 37(9):2974-2984.

[27]JungSR, SongNJ, YangDK, et al., 2013. Silk proteins stimulate osteoblast differentiation by suppressing the Notch signaling pathway in mesenchymal stem cells. Nutr Res, 33(2):162-170.

[28]KumarS, SinghSK, 2017. Fabrication and characterization of fibroin solution and nanoparticle from silk fibers of Bombyx mori. Part Sci Technol, 35(3):304-313.

[29]LimWL, LiauLL, NgMH, et al., 2019. Current progress in tendon and ligament tissue engineering. Tissue Eng Regen Med, 16(6):549-571.

[30]LujerdeanC, BaciGM, CucuAA, et al., 2022. The contribution of silk fibroin in biomedical engineering. Insects, 13(3):286.

[31]LuoZW, LiJ, QuJ, et al., 2019. Cationized Bombyx mori silk fibroin as a delivery carrier of the VEGF165-Ang-1 coexpression plasmid for dermal tissue regeneration. J Mater Chem B, 7(1):80-94.

[32]MaXY, MaTC, FengYF, et al., 2021. Promotion of osteointegration under diabetic conditions by a silk fibroin coating on 3D-printed porous titanium implants via a ROS-mediated NF-‍κB pathway. Biomed Mater, 16(3):035015.

[33]MelkeJ, MidhaS, GhoshS, et al., 2016. Silk fibroin as biomaterial for bone tissue engineering. Acta Biomater, 31:1-16.

[34]MidhaS, MurabS, GhoshS, 2016. Osteogenic signaling on silk-based matrices. Biomaterials, 97:133-153.

[35]MuangsanitP, ShipleyRJ, PhillipsJB, 2018. Vascularization strategies for peripheral nerve tissue engineering. Anat Rec, 301(10):1657-1667.

[36]OjahN, BorahR, AhmedGA, et al., 2020. Surface modification of electrospun silk/AMOX/PVA nanofibers by dielectric barrier discharge plasma: physiochemical properties, drug delivery and in-vitro biocompatibility. Prog Biomater, 9(4):219-237.

[37]QianYN, LiLH, SongY, et al., 2018. Surface modification of nanofibrous matrices via layer-by-layer functionalized silk assembly for mitigating the foreign body reaction. Biomaterials, 164:22-37.

[38]QiaoF, ZhangJJ, WangJH, et al., 2017. Silk fibroin-coated PLGA dimpled microspheres for retarded release of simvastatin. Colloids Surf B Biointerfaces, 158:112-118.

[39]QuYY, HongG, LiuL, et al., 2019. Evaluation of silk fibroin electrogel coating for zirconia material surface. Dent Mater J, 38(5):813-820.

[40]RahmanM, BaluR, AbrahamA, et al., 2021. Engineering a bioactive hybrid coating for in vitro corrosion control of magnesium and its alloy. ACS Appl Bio Mater, 4(7):‍5542-5555.

[41]Rnjak-KovacinaJ, DesRochersTM, BurkeKA, et al., 2015. The effect of sterilization on silk fibroin biomaterial properties. Macromol Biosci, 15(6):861-874.

[42]SahaS, PramanikK, BiswasA, 2019. Silk fibroin coated TiO2 nanotubes for improved osteogenic property of Ti6Al4V bone implants. Mater Sci Eng C, 105:109982.

[43]SchünemannFH, Galárraga-VinuezaME, MaginiR, et al., 2019. Zirconia surface modifications for implant dentistry. Mater Sci Eng C, 98:1294-1305.

[44]SethiN, KangYB, 2012. Notch signaling: mediator and therapeutic target of bone metastasis. Bonekey Rep, 1:3.

[45]SharmaS, BanoS, GhoshAS, et al., 2016. Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface. Nanomedicine, 12(5):‍1193-1204.

[46]ŠiškováAO, MosnáčkováK, HrůzaJ, et al., 2021. Electrospun poly(ethylene terephthalate)/silk fibroin composite for filtration application. Polymers, 13(15):2499.

[47]SunBB, ZhouZF, LiDW, et al., 2019. Polypyrrole-coated poly(L-lactic acid-co-‍ε‍-caprolactone)/silk fibroin nanofibrous nerve guidance conduit induced nerve regeneration in rat. Mater Sci Eng C, 94:190-199.

[48]SunYM, HuC, YangYY, et al., 2019. Fibroin/peptide co-functionalized calcium titanate nanorods improve osteoinductivity of titanium via mimicking osteogenic niche. Mater Sci Eng C, 103:109836.

[49]TanMX, LiuWW, LiuFQ, et al., 2019. Silk fibroin-coated nanoagents for acidic lysosome targeting by a functional preservation strategy in cancer chemotherapy. Theranostics, 9(4):961-973.

[50]UnalanI, ColpankanO, AlbayrakAZ, et al., 2016. Biocompatibility of plasma-treated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofiber mats modified by silk fibroin for bone tissue regeneration. Mater Sci Eng C, 68:842-850.

[51]Valencia-LazcanoAA, Román-DovalR, de la Cruz-BureloE, et al., 2018. Enhancing surface properties of breast implants by using electrospun silk fibroin. J Biomed Mater Res Part B Appl Biomater, 106(5):1655-1661.

[52]VigK, ChaudhariA, TripathiS, et al., 2017. Advances in skin regeneration using tissue engineering. Int J Mol Sci, 18(4):789.

[53]WangCY, WangSN, YangYY, et al., 2018a. Bioinspired, biocompatible and peptide-decorated silk fibroin coatings for enhanced osteogenesis of bioinert implant. J Biomater Sci Polym Ed, 29(13):1595-1611.

[54]WangCY, JiaYC, YangWC, et al., 2018b. Silk fibroin enhances peripheral nerve regeneration by improving vascularization within nerve conduits. J Biomed Mater Res Part A, 106(7):2070-2077.

[55]WangSG, HuF, LiJC, et al., 2018. Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells. Nanomed Nanotechnol Biol Med, 14(7):2505-2520.

[56]WangX, GuZP, JiangB, et al., 2016. Surface modification of strontium-doped porous bioactive ceramic scaffolds via poly(DOPA) coating and immobilizing silk fibroin for excellent angiogenic and osteogenic properties. Biomater Sci, 4(4):678-688.

[57]WatanabeM, BhawalUK, TakemotoS, et al., 2021. Bio-functionalized titanium surfaces with modified silk fibroin carrying titanium binding motif to enhance the ossific differentiation of MC3T3-E1. Biotechnol Bioeng, 118(7):2585-2596.

[58]WenkE, MerkleHP, MeinelL, 2011. Silk fibroin as a vehicle for drug delivery applications. J Controlled Release, 150(2):128-141.

[59]XiongP, JiaZJ, LiM, et al., 2018. Biomimetic Ca, Sr/P-doped silk fibroin films on Mg-1Ca alloy with dramatic corrosion resistance and osteogenic activities. ACS Biomater Sci Eng, 4(9):3163-3176.

[60]XiongP, JiaZJ, ZhouWH, et al., 2019a. Osteogenic and pH stimuli-responsive self-healing coating on biomedical Mg-1Ca alloy. Acta Biomater, 92:336-350.

[61]XiongP, YanJL, WangP, et al., 2019b. A pH-sensitive self-healing coating for biodegradable magnesium implants. Acta Biomater, 98:160-173.

[62]XuW, YagoshiK, AsakuraT, et al., 2020. Silk fibroin as a coating polymer for sirolimus-eluting magnesium alloy stents. ACS Appl Bio Mater, 3(1):531-538.

[63]YamanoM, HiroseR, LyePY, et al., 2022. Bioengineered silkworm for producing cocoons with high fibroin content for regenerated fibroin biomaterial-based applications. Int J Mol Sci, 23(13):7433.

[64]YangMY, ZhouGS, ShuaiYJ, et al., 2015. Ca2+-induced self-assembly of Bombyx mori silk sericin into a nanofibrous network-like protein matrix for directing controlled nucleation of hydroxylapatite nano-needles. J Mater Chem B, 3(12):2455-2462.

[65]YaoMZ, Huang-FuMY, LiuHN, et al., 2016. Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin. Int J Nanomedicine, 11:6181-6194.

[66]YeXG, LiS, ChenXX, et al., 2017. Polyethylenimine/silk fibroin multilayers deposited nanofibrics for cell culture. Int J Biol Macromol, 94(Part A):492-499.

[67]YucelT, LovettML, KaplanDL, 2014. Silk-based biomaterials for sustained drug delivery. J Controlled Release, 190:381-397.

[68]ZhangY, ShiN, HeL, et al., 2021. Silk sericin activates mild immune response and increases antibody production. J Biomed Nanotechnol, 17(12):2433-2443.

[69]ZhouWH, JiaZJ, XiongP, et al., 2017. Bioinspired and biomimetic AgNPs/gentamicin-embedded silk fibroin coatings for robust antibacterial and osteogenetic applications. ACS Appl Mater Interfaces, 9(31):25830-25846.

[70]ZhouWH, ZhangT, YanJL, et al., 2020. In vitro and in vivo evaluation of structurally-controlled silk fibroin coatings for orthopedic infection and in-situ osteogenesis. Acta Biomater, 116:223-245.

[71]ZhouWH, YanJL, LiYY, et al., 2021. Based on the synergistic effect of Mg2+ and antibacterial peptides to improve the corrosion resistance, antibacterial ability and osteogenic activity of magnesium-based degradable metals. Biomater Sci, 9(3):807-825.

[72]ZhuL, LinJX, PeiLJ, et al., 2022. Recent advances in environmentally friendly and green degumming processes of silk for textile and non-textile applications. Polymers, 14(4):659.

[73]ZiembaAM, FinkTD, CrochiereMC, et al., 2020. Coating topologically complex electrospun fibers with nanothin silk fibroin enhances neurite outgrowth in vitro. ACS Biomater Sci Eng, 6(3):1321-1332.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE