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CLC number: R54; R743

On-line Access: 2019-05-15

Received: 2019-03-28

Revision Accepted: 2019-04-11

Crosschecked: 2019-04-27

Cited: 0

Clicked: 2262

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Li-sheng Zhuo

https://orcid.org/0000-0001-6480-2393

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.428-436

http://doi.org/10.1631/jzus.B1900155


Roles of hyaluronan in cardiovascular and nervous system disorders


Author(s):  Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo

Affiliation(s):  Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; more

Corresponding email(s):   zhuols@gmail.com

Key Words:  Hyaluronic acid, Extracellular matrix, Cardiovascular vessel, Heart, Brain


Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo. Roles of hyaluronan in cardiovascular and nervous system disorders[J]. Journal of Zhejiang University Science B, 2019, 20(5): 428-436.

@article{title="Roles of hyaluronan in cardiovascular and nervous system disorders",
author="Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo",
journal="Journal of Zhejiang University Science B",
volume="20",
number="5",
pages="428-436",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900155"
}

%0 Journal Article
%T Roles of hyaluronan in cardiovascular and nervous system disorders
%A Hong-yan Ding
%A Ya-nan Xie
%A Qiang Dong
%A Koji Kimata
%A Yoshihiro Nishida
%A Naoki Ishiguro
%A Li-sheng Zhuo
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 5
%P 428-436
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900155

TY - JOUR
T1 - Roles of hyaluronan in cardiovascular and nervous system disorders
A1 - Hong-yan Ding
A1 - Ya-nan Xie
A1 - Qiang Dong
A1 - Koji Kimata
A1 - Yoshihiro Nishida
A1 - Naoki Ishiguro
A1 - Li-sheng Zhuo
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 5
SP - 428
EP - 436
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900155


Abstract: 
Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.

透明质酸在心血管和脑病变中的作用

目的:透明质酸是细胞外基质的重要组成成分,不仅具有结构支撑功能,而且还积极参与调节细胞的功能.透明质酸的理化学和生物学特性受其自身的分子量大小以及数十种结合蛋白的影响,从而在众多的生理和病理过程中展现出多姿多彩的生物学功能.本文以心血管和脑病变为中心,总结透明质酸在这些病变的发生和修复过程中的作用,以期服务于今后的基础研究和临床实践.
关键词:透明质酸; 细胞外基质;心血管;心脏;脑

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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