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On-line Access: 2024-12-30
Received: 2023-11-26
Revision Accepted: 2024-03-26
Crosschecked: 2024-12-30
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Citations: Bibtex RefMan EndNote GB/T7714
Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
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Liwen WANG, Huimei LIU, Lanfang LI. Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation[J]. Journal of Zhejiang University Science B, 2024, 25(12): 1115-1119.
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author="Liwen WANG, Huimei LIU, Lanfang LI",
journal="Journal of Zhejiang University Science B",
volume="25",
number="12",
pages="1115-1119",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300853"
}
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%T Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300853
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Abstract: Neurodegenerative diseases (NDDs), mainly including Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD), are sporadic and rare genetic disorders of the central nervous system. A key feature of these conditions is the slow accumulation of misfolded protein deposits in brain neurons, the excessive aggregation of which leads to neurotoxicity and further disorders of the nervous system.
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