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Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
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Liwen WANG, Huimei LIU, Lanfang LI. Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation",
author="Liwen WANG, Huimei LIU, Lanfang LI",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300853"
}
%0 Journal Article
%T Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
%A Liwen WANG
%A Huimei LIU
%A Lanfang LI
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300853
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T1 - Autophagy receptor-inspired chimeras: A novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
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A1 - Huimei LIU
A1 - Lanfang LI
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
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%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300853
Abstract: Neurodegenerative diseases are genetic disorders of the central nervous system. Their key feature is the slow accumulation of misfolded protein deposits in brain neurons. While autophagy is known to play a crucial role in degrading protein aggregates, there is currently no effective and widely applicable method for the degradation of protein aggregates in mammalian cells. The latest data demonstrate that synthetic autophagy receptor-inspired targeting chimeras (AceTACs) act as degraders that can combine the LIR domain of the selective autophagy receptor-p62 with antibodies. Different protein aggregates (such as mHTT, TDP-43, and Tau) can be selectively targeted for disintegration by AceTAC degraders. Moreover, these degraders can target intracellular organelles including mitochondria, peroxisomes, and endoplasmic reticulum. Therefore, AceTACs represent promising autophagy-based targeted degraders that could offer a novel approach to effectively treat neurodegenerative diseases..
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