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Yizhou WANG

0000-0002-2188-383X

Zhuhong ZHANG

0000-0001-6720-0996

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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.5 P.361-388

http://doi.org/10.1631/jzus.B2300854


Ceria nanoparticles: biomedical applications and toxicity


Author(s):  Xiaoxuan FU, Peng LI, Xi CHEN, Yuanyuan MA, Rong WANG, Wenxuan JI, Jiakuo GU, Bowen SHENG, Yizhou WANG, Zhuhong ZHANG

Affiliation(s):  School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China; more

Corresponding email(s):   zhzhang0608@ytu.edu.cn, wangyizhou@zju.edu.cn

Key Words:  Ceria nanoparticle, Synthetic method, Biomedical application, Oxidative stress, Toxicity


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Xiaoxuan FU, Peng LI, Xi CHEN, Yuanyuan MA, Rong WANG, Wenxuan JI, Jiakuo GU, Bowen SHENG, Yizhou WANG, Zhuhong ZHANG. Ceria nanoparticles: biomedical applications and toxicity[J]. Journal of Zhejiang University Science B, 2024, 25(5): 361-388.

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journal="Journal of Zhejiang University Science B",
volume="25",
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pages="361-388",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300854"
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Abstract: 
ceria nanoparticles (CeO2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO2 NPs. Due to the wide application of CeO2 NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO2 NPs, including their use in the treatment of various diseases (e.‍g., Alzheimer’s disease, ischemic stroke, retinal damage, chronic inflammation, and cancer). CeO2 NP toxicity is discussed in terms of the different systems of the human body (e.‍g., cytotoxicity, genotoxicity, respiratory toxicity, neurotoxicity, and hepatotoxicity). This comprehensive review covers both fundamental discoveries and exploratory progress in CeO2 NP research that may lead to practical developments in the future.

二氧化铈纳米颗粒:生物医学应用和毒性

付晓暄1,李鹏2,陈茜1,马圆圆1,王榕1,姬文轩1,谷家阔1,生博文1,王一州3,张竹红1
1烟台大学药学院,分子药理学与药物评价教育部重点实验室,山东高校先进给药系统与生物技术药物协同创新中心,中国烟台市,264005
2青岛大学烟台毓璜顶医院肾内科,中国烟台市,264005
3浙江大学农业与生物技术学院作物科学研究所,中国杭州市,310058
摘要:二氧化铈纳米颗粒(CeO2 NPs)因其在抗氧化、癌症治疗、光催化降解污染物和传感器等方面的潜在应用而成为生物医学和工业领域的热门材料。目前已经报道了气相、固相、液相以及新提出的绿色合成等多种合成CeO2 NPs的方法。随着CeO2 NPs的广泛应用,人们对其可能带来的健康隐患感到担忧。本文综述了近年来CeO2 NPs在生物医学领域的应用研究,包括其对各种疾病(如阿尔茨海默病、缺血性中风、视网膜损伤、慢性炎症和癌症)的治疗,并讨论了CeO2 NPs对人体的不同系统的毒性,如细胞毒性、遗传毒性、呼吸毒性、神经毒性和肝毒性。总之,该综述全面涵盖了CeO2 NPs研究的重大发现及其探索性进展,对未来的实践发展具有重要的参考价值。

关键词:二氧化铈纳米颗粒;合成方法;生物医学应用程序;氧化应激;毒性

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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