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Zhengcheng HE, Haitao HUANG, Jiale FANG, Huiping LIU, Xudong YAO, Hongwei WU. From 2D to 3D: transforming malignant bone tumor research with advanced culture models[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="From 2D to 3D: transforming malignant bone tumor research with advanced culture models",
author="Zhengcheng HE, Haitao HUANG, Jiale FANG, Huiping LIU, Xudong YAO, Hongwei WU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400288"
}
%0 Journal Article
%T From 2D to 3D: transforming malignant bone tumor research with advanced culture models
%A Zhengcheng HE
%A Haitao HUANG
%A Jiale FANG
%A Huiping LIU
%A Xudong YAO
%A Hongwei WU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400288
TY - JOUR
T1 - From 2D to 3D: transforming malignant bone tumor research with advanced culture models
A1 - Zhengcheng HE
A1 - Haitao HUANG
A1 - Jiale FANG
A1 - Huiping LIU
A1 - Xudong YAO
A1 - Hongwei WU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400288
Abstract: osteosarcoma (OS), chondrosarcoma (CS), and ewing sarcoma (ES) represent the primary malignant bone tumors and pose significant challenges in oncology research and clinical management. Conventional research methods, such as 2D cultured tumor cells and animal models, have limitations in recapitulating the complex tumor microenvironment (TME) and often fail to translate into effective clinical treatments. The advancement of 3D culture technology has revolutionized the field by enabling the development of in vitro constructed bone tumor models that closely mimic the in vivo TME. These models provide a powerful tool for investigating tumor biology, assessing therapeutic responses, and advancing personalized medicine. This comprehensive review summarizes the recent advancements in research on in vitro constructed 3D tumor models for OS, CS, and ES. We discuss the various techniques employed in model construction, their applications, and the challenges and future directions in this field. The integration of advanced technologies and the incorporation of additional cell types hold promise for the development of more sophisticated and physiologically relevant models. As research in this field continues to evolve, we anticipate that these models will play an increasingly crucial role in unraveling the complexities of malignant bone tumors and accelerating the development of novel therapeutic strategies.
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