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Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing
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SimingLu, JingweiZhang, ShaLin, DanfengZheng, YanShen, JialeQin, YangyangLi, ShuqiWang . Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing[J]. Journal of Zhejiang University Science D, 2021, 4(4): 717-734.
@article{title="Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing",
author="SimingLu, JingweiZhang, ShaLin, DanfengZheng, YanShen, JialeQin, YangyangLi, ShuqiWang ",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="717-734",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00142-7"
}
%0 Journal Article
%T Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing
%A SimingLu
%A JingweiZhang
%A ShaLin
%A DanfengZheng
%A YanShen
%A JialeQin
%A YangyangLi
%A ShuqiWang
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 717-734
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00142-7
TY - JOUR
T1 - Recent advances inthedevelopment ofinvitro liver models forhepatotoxicity testing
A1 - SimingLu
A1 - JingweiZhang
A1 - ShaLin
A1 - DanfengZheng
A1 - YanShen
A1 - JialeQin
A1 - YangyangLi
A1 - ShuqiWang
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 717
EP - 734
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00142-7
Abstract: liver injury is a common cause of drug approval withdrawal during drug development, pre-clinical research, and clinical
treatment. If not properly treated, patients with severe liver injury can sufer from acute liver failure or even death. Thus,
utilization of the convenient invitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is
vital for drug development and safe personalized medication. Biomaterials (e.g., hydrogels, nanofbers, decellularized liver
matrix) and bioengineering technologies (e.g., microarrays, micropatterns, 3D printing, and microfuidics) have been applied
for invitro hepatotoxicity assessment models. This review summarizes the structure and functions of the liver as well as
the components of invitro hepatotoxicity assessment models. In addition, it highlights the latest advances in developing
hepatotoxicity models with the ultimate goal of further clinical translation.
Open peer comments: Debate/Discuss/Question/Opinion
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