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A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation
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Yingjie Liu , Ling Wang，Jie Zhang , Shuguang Liu , Jibao Zheng , Jianfeng Kang , Enchun Dong , Changning Sun , Ruhan A , Chaozong Liu , Chuncheng Yang, Dichen Li. A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="A design strategy developed for long term stability of porous
PEEK implants through the combined regulation of porous
structure and in vivo mechanical stimulation",
author="Yingjie Liu , Ling Wang，Jie Zhang , Shuguang Liu , Jibao Zheng , Jianfeng Kang , Enchun Dong , Changning Sun , Ruhan A , Chaozong Liu , Chuncheng Yang, Dichen Li",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400259"
}
%0 Journal Article
%T A design strategy developed for long term stability of porous
PEEK implants through the combined regulation of porous
structure and in vivo mechanical stimulation
%A Yingjie Liu
%A Ling Wang，Jie Zhang
%A Shuguang Liu
%A Jibao Zheng
%A Jianfeng Kang
%A Enchun Dong
%A Changning Sun
%A Ruhan A
%A Chaozong Liu
%A Chuncheng Yang
%A Dichen Li
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400259
TY - JOUR
T1 - A design strategy developed for long term stability of porous
PEEK implants through the combined regulation of porous
structure and in vivo mechanical stimulation
A1 - Yingjie Liu
A1 - Ling Wang，Jie Zhang
A1 - Shuguang Liu
A1 - Jibao Zheng
A1 - Jianfeng Kang
A1 - Enchun Dong
A1 - Changning Sun
A1 - Ruhan A
A1 - Chaozong Liu
A1 - Chuncheng Yang
A1 - Dichen Li
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400259
Abstract: The bioinert nature of PEEK material limits the widespread clinical application of PEEK
implants. Although the porous structure is believed to improve the osseointegration
performance of PEEK implants, it is hardly used due to the decreased mechanical properties.
This study investigates the combined influence of the porous structure and the in vivo
mechanical stimulation on implantation safety and bone growth based on the finite element
analysis of the biomechanical behavior of the implantation system. It is shown that with the
combined control of pore size and screw preloads, the porous PEEK implant can achieve good
osseointegration while maintain a relatively high safety level. The optimal combination of pore
size and the screw preload are derived. With the pore size of 600 μm and the preload of 0.05
N·m, the safety factor of the implant exceeds 2, and the predicted percentage of the effective
bone growth area of the bone-implant interface reaches 97%. The PEEK implants were
fabricated by FFF 3D printing technique for further clinical applications. The clinical outcomes
demonstrated the better bone repair efficacy and long-term stability of the porous PEEK
implants compared to the solid PEEK implants. Good osteointegration performance of the 3D
printed porous PEEK implants was shown with the average BV/TV exceeding 40% 3 months
after implantation. In conclusion, the 3D printed porous PEEK implants have great potential
for clinical application with validated implantation safety and good osseointegration.
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