Full Text:
<49>
CLC number:
On-line Access: 2025-09-19
Received: 2024-09-21
Revision Accepted: 2025-03-05
Crosschecked: 0000-00-00
Cited: 0
Clicked: 68
|
Targeting cyclooxygenase-2 using photothermal-anti-inflammatory nanoparticles to inhibit tumor growth and metastasis
| |||||||||||||
Jiahui Cai (蔡嘉慧), Zutong Cui (崔祖彤), Wenming Liang (梁文明), Jianming Sun (孙健铭), Zihan Zhang (张子涵), Shasha Zhao (赵莎莎), Zhiwei Liu (刘志伟), Xiaoling Li (李晓玲) & Jian Li (李健) . Targeting cyclooxygenase-2 using photothermal-anti-inflammatory nanoparticles to inhibit tumor growth and metastasis[J]. Journal of Zhejiang University Science D, 2025, 8(5): 759-775.
@article{title=" Targeting cyclooxygenase-2 using photothermal-anti-inflammatory
nanoparticles to inhibit tumor growth and metastasis",
author="Jiahui Cai (蔡嘉慧), Zutong Cui (崔祖彤), Wenming Liang (梁文明), Jianming Sun (孙健铭), Zihan Zhang (张子涵), Shasha Zhao (赵莎莎), Zhiwei Liu (刘志伟), Xiaoling Li (李晓玲) & Jian Li (李健) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="759-775",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400470"
}
%0 Journal Article
%T Targeting cyclooxygenase-2 using photothermal-anti-inflammatory
nanoparticles to inhibit tumor growth and metastasis
%A Jiahui Cai (蔡嘉慧)
%A Zutong Cui (崔祖彤)
%A Wenming Liang (梁文明)
%A Jianming Sun (孙健铭)
%A Zihan Zhang (张子涵)
%A Shasha Zhao (赵莎莎)
%A Zhiwei Liu (刘志伟)
%A Xiaoling Li (李晓玲) & Jian Li (李健)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 759-775
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400470
TY - JOUR
T1 - Targeting cyclooxygenase-2 using photothermal-anti-inflammatory
nanoparticles to inhibit tumor growth and metastasis
A1 - Jiahui Cai (蔡嘉慧)
A1 - Zutong Cui (崔祖彤)
A1 - Wenming Liang (梁文明)
A1 - Jianming Sun (孙健铭)
A1 - Zihan Zhang (张子涵)
A1 - Shasha Zhao (赵莎莎)
A1 - Zhiwei Liu (刘志伟)
A1 - Xiaoling Li (李晓玲) & Jian Li (李健)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 759
EP - 775
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400470
Abstract: Photothermal therapy (PTT) is a non-invasive and highly selective tumor treatment. However, it triggers an inflammatory re
action and other adverse effects, including damage to the surrounding healthy tissue and an increased risk of tumor prolifera
tion and metastasis. The cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway plays a crucial role in regulating
tumor development. In this study, we revealed that PTT activates the COX-2/PGE2 pathway. To mitigate the PTT-induced
inflammation, based on polydopamine (PDA) and HS-β-cyclodextrin (HS-β-CD), we constructed a photothermal/anti
inflammatory nanoparticle system (named ICG@PDA-β-CD/CEL) loaded with the anti-inflammatory drug celecoxib (CEL)
and the photosensitizer indocyanine green (ICG), which targets COX-2. This system helps PTT by (1) reducing pro
inflammatory molecules such as PGE2, tumor necrosis factor-α, and interleukin-6 and inhibiting the COX-2 and nuclear fac
tor kappa-B signaling pathways, (2) suppressing vascular endothelial growth factor production to inhibit tumor angiogenesis,
and (3) preventing tumor cell migration and invasion. Further results indicated that ICG@PDA-β-CD/CEL significantly cur
tailed tumor cell invasion and migration in vitro and suppressed the COX-2/PGE2 pathway in vivo, thereby markedly inhibit
ing both orthotopic tumor growth and metastasis. ICG@PDA-β-CD/CEL exhibits potent antitumor effects through its com
bined anti-inflammatory and photothermal therapies, providing a promising strategy for alleviating PTT-related adverse
effects.
Open peer comments: Debate/Discuss/Question/Opinion
<1>