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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.9 P.931-935

http://doi.org/10.1631/jzus.2005.B0931


Study of androgen and atherosclerosis in old-age male


Author(s):  YANG Yun-mei, LV Xue-ying, HUANG Wei-dong, XU Zhe-rong, WU Ling-jiao

Affiliation(s):  Department of Very Important People, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   xuzherong@sina.com, Huangweidong2003@hotmail.com

Key Words:  Atherosclerosis, Old-age male, Androgen, Free testosterone, Inflammatory cytokine


YANG Yun-mei, LV Xue-ying, HUANG Wei-dong, XU Zhe-rong, WU Ling-jiao. Study of androgen and atherosclerosis in old-age male[J]. Journal of Zhejiang University Science B, 2005, 6(9): 931-935.

@article{title="Study of androgen and atherosclerosis in old-age male",
author="YANG Yun-mei, LV Xue-ying, HUANG Wei-dong, XU Zhe-rong, WU Ling-jiao",
journal="Journal of Zhejiang University Science B",
volume="6",
number="9",
pages="931-935",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0931"
}

%0 Journal Article
%T Study of androgen and atherosclerosis in old-age male
%A YANG Yun-mei
%A LV Xue-ying
%A HUANG Wei-dong
%A XU Zhe-rong
%A WU Ling-jiao
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 9
%P 931-935
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0931

TY - JOUR
T1 - Study of androgen and atherosclerosis in old-age male
A1 - YANG Yun-mei
A1 - LV Xue-ying
A1 - HUANG Wei-dong
A1 - XU Zhe-rong
A1 - WU Ling-jiao
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 9
SP - 931
EP - 935
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0931


Abstract: 
Objective: To observe the difference of androgen and inflammatory cytokines level in atherosclerosis and analyse their relations. Method: Both carotid arteries and arteries of lower extremity were subjected to ultrasonic examination by Doppler’s method. Those with much atheromatous plaque formation were ranged into case group, and those with normal result formed control group. Total, free testosterone and estradiol were assayed by radioimmunoassay. C reactive protein (CRP) was assayed by nepheloturbidity. Tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), Interleukin-18 (IL-18), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) were assayed by ELISA. The mean difference between two groups and the correlation between free testosterone and cytokines were analysed. Results: free testosterone was (6.337±3.371) pg/L in case group and (11.375±4.733) pg/L in control group, P<0.01. No differences were found in total testosterone and estradiol. CRP was (27.294±10.238) mg/L in case group and (12.843±6.318) mg/L in control group, P<0.01. IL-6 was (41.700±31.385) pg/L in case group and (25.396±20.772) pg/L in control group, P<0.05. IL-8 was (89.249±58.357) pg/L in case group and (67.873±31.227) pg/L in control group, P<0.05. sICAM-1 was (470.491±134.078) pg/L in case group and (368.487±97.183) pg/L in control group, P<0.01. sVCAM-1 was (537.808±213.172) pg/L in case group and (457.275±157.273) pg/L in control group, P<0.05. There were no differences in TNF-α, IL-10 and IL-18. Correlation analysis showed that FT (free testosterone) had negative correlation with CRP, IL-6 and sICAM-1. Among them FT had well correlation with CRP, correlation index was −0.678. Conclusion: free testosterone was in negative correlation with atherosclerosis in old-age male. free testosterone may have the role of anti-atherosclerosis, and this effect was not achieved by its transformation to estradiol. Low free testosterone level was followed by increased level of inflammatory cytokines. Low free testosterones coexist with inflammation and they both affect the process of atherosclerosis in old-age male.

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