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On-line Access: 2025-09-09
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Designsimulationmanufacturingassessment framework for geometric optimization of polymeric heart valves toward enhanced durability
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Tianle Xu (???), Zihan Zhu (???), Yunhan Cai (???), Shunping Chen (???), Jia Guo (??) & Shengzhang Wang (???) . Designsimulationmanufacturingassessment framework for geometric optimization of polymeric heart valves toward enhanced durability[J]. Journal of Zhejiang University Science D, 2025, 8(5): 835-846.
@article{title="Designsimulationmanufacturingassessment framework for geometric
optimization of polymeric heart valves toward enhanced durability",
author="Tianle Xu (???), Zihan Zhu (???), Yunhan Cai (???), Shunping Chen (???), Jia Guo (??) & Shengzhang Wang (???) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="835-846",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500046"
}
%0 Journal Article
%T Designsimulationmanufacturingassessment framework for geometric
optimization of polymeric heart valves toward enhanced durability
%A Tianle Xu (???)
%A Zihan Zhu (???)
%A Yunhan Cai (???)
%A Shunping Chen (???)
%A Jia Guo (??) & Shengzhang Wang (???)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 835-846
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500046
TY - JOUR
T1 - Designsimulationmanufacturingassessment framework for geometric
optimization of polymeric heart valves toward enhanced durability
A1 - Tianle Xu (???)
A1 - Zihan Zhu (???)
A1 - Yunhan Cai (???)
A1 - Shunping Chen (???)
A1 - Jia Guo (??) & Shengzhang Wang (???)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 835
EP - 846
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500046
Abstract: Owing to their excellent biocompatibility and potential for durability enhancement, polymeric heart valves (PHVs) are
emerging as a promising alternative to traditional prostheses. Unlike conventional materials, PHVs can be manufactured un?
der precise design criteria, enabling targeted performance improvements. This study introduces a geometric optimization
strategy for enhancing the durability of PHVs. The finite element method (FEM) is combined with a dip-molding technique
to develop a novel polymeric aortic valve with improved mechanical properties. The tri-leaflet geometry is parameterized us?
ing B-spline curves, and the maximum stress in the valve is reduced from 2.4802 to 1.7773 MPa using a multiobjective opti?
mization algorithm NSGA-II (non-dominated sorting genetic algorithm II). Pre-optimized and optimized valve prototypes
were fabricated via dip-molding and evaluated during pulsatile-flow tests and accelerated wear tests. The optimized design
meets the ISO 5840 standards, with an effective orifice area of 2.019 cm2
, a regurgitant fraction of 5.693%, and a transvalvu?
lar pressure gradient of 7.576 mmHg. Moreover, the optimized valve maintained its structural integrity and functionality
over 14 million cycles of the accelerated wear test, whereas the unoptimized valve failed after two million cycles. These find?
ings confirm that the FEM-based geometric optimization method enhances both the mechanical performance and durability
of PHVs
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